Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15192 |
Resumo: | Fundação de Amparo a Pesquisa do Estado da Bahia - FAPESB; Conselho Nacional de Pesquisa - CNPq |
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Peixoto, MaíraMascarenhas, LaysCunha, AndréDutra, MargaridaMiranda, EvaSilva, IvoCosta, SandraCastro Filho, Bernardo GalvãoCunha, Andréa2016-08-03T16:41:33Z2016-08-03T16:41:33Z2012PEIXOTO, M. et al. Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene. Antiviral Therapy, v. 17, p. 585-588, 2016.1359-6535https://www.arca.fiocruz.br/handle/icict/1519210.3851/IMP1938Fundação de Amparo a Pesquisa do Estado da Bahia - FAPESB; Conselho Nacional de Pesquisa - CNPqFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilHospital Portuguese. Transplantation Service Department. Salvador, BA, BrasilHospital Portuguese. Service of Nephrology. Salvador, BA, BrasilHospital Portuguese. Service of Nephrology. Salvador, BA, BrasilHospital Portuguese. Service of Nephrology. Salvador, BA, BrasilUniversidade Estadual de Campinas. Laboratório de Diagnóstico Molecular de Doenças Infecciosas. Campinas, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilGanciclovir (GCV) is the first therapeutic choice for prevention and treatment of active cytomegalovirus (CMV) infection in solid organ transplant recipients in Bahia state, Brazil. Prolonged and repeated GCV therapy may result in drug-resistant virus, associated with progressive and disseminated disease. We present a case report of a young male kidney recipient, who was CMV-seronegative with a CMV-seropositive donor (D(+)/R(-)), and who developed clinical GCV resistance, confirmed by mutation in viral UL97 phosphotransferase responsible for GCV activation. Under prophylactic therapy with intravenous GCV for 6 weeks post-transplantation, he developed severe anaemia and hepatic enzyme increases, probably due to drug side effects. At this moment, the drug was discontinued and he started to be monitored by pp65 antigen test. At week 10 post-transplantation, he presented fever, myalgia, thrombocytopenia and neutropaenia, with a positive CMV antigen test. During treatment with intravenous GCV, antigenaemia assay demonstrated a higher number of positive cells, requiring GCV at higher doses. Pre-emptive therapy lasted for 31 days and he started the maintenance therapy with oral GCV. However, antigenaemia assay demonstrated an extremely high number of positive cells, and he was rehospitalized and prescribed intravenous GCV. Severe leukopaenia led to GCV interruption, but immunosuppressive dose reduction helped to control the active CMV infection. GCV-resistant CMV infection resulted in increased morbidity, rehospitalization episodes and increased costs; therefore, implementation of resistance diagnostic tests in the transplantation routine is of great importance. We documented the first case of GCV-resistant CMV infection due to the L595S mutation in UL97 phosphotransferase gene in a kidney recipient from Bahia state, Brazil.engInternational Medical PressRecurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase geneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAntiviral agentsCytomegalovirusCytomegalovirus infectionDrug Resistance, viralBrazilHumansKidney transplantationMaleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15192/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPeixoto M Recurrent....pdfPeixoto M Recurrent....pdfapplication/pdf170874https://www.arca.fiocruz.br/bitstream/icict/15192/2/Peixoto%20M%20Recurrent....pdfaed9483eacf69727fbc6457a1ddd7cf4MD52TEXTPeixoto M Recurrent....pdf.txtPeixoto M Recurrent....pdf.txtExtracted texttext/plain0https://www.arca.fiocruz.br/bitstream/icict/15192/3/Peixoto%20M%20Recurrent....pdf.txtd41d8cd98f00b204e9800998ecf8427eMD53icict/151922023-03-15 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dc.title.pt_BR.fl_str_mv |
Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene |
title |
Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene |
spellingShingle |
Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene Peixoto, Maíra Antiviral agents Cytomegalovirus Cytomegalovirus infection Drug Resistance, viral Brazil Humans Kidney transplantation Male |
title_short |
Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene |
title_full |
Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene |
title_fullStr |
Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene |
title_full_unstemmed |
Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene |
title_sort |
Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene |
author |
Peixoto, Maíra |
author_facet |
Peixoto, Maíra Mascarenhas, Lays Cunha, André Dutra, Margarida Miranda, Eva Silva, Ivo Costa, Sandra Castro Filho, Bernardo Galvão Cunha, Andréa |
author_role |
author |
author2 |
Mascarenhas, Lays Cunha, André Dutra, Margarida Miranda, Eva Silva, Ivo Costa, Sandra Castro Filho, Bernardo Galvão Cunha, Andréa |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Peixoto, Maíra Mascarenhas, Lays Cunha, André Dutra, Margarida Miranda, Eva Silva, Ivo Costa, Sandra Castro Filho, Bernardo Galvão Cunha, Andréa |
dc.subject.en.pt_BR.fl_str_mv |
Antiviral agents Cytomegalovirus Cytomegalovirus infection Drug Resistance, viral Brazil Humans Kidney transplantation Male |
topic |
Antiviral agents Cytomegalovirus Cytomegalovirus infection Drug Resistance, viral Brazil Humans Kidney transplantation Male |
description |
Fundação de Amparo a Pesquisa do Estado da Bahia - FAPESB; Conselho Nacional de Pesquisa - CNPq |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2016-08-03T16:41:33Z |
dc.date.available.fl_str_mv |
2016-08-03T16:41:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PEIXOTO, M. et al. Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene. Antiviral Therapy, v. 17, p. 585-588, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/15192 |
dc.identifier.issn.pt_BR.fl_str_mv |
1359-6535 |
dc.identifier.doi.none.fl_str_mv |
10.3851/IMP1938 |
identifier_str_mv |
PEIXOTO, M. et al. Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene. Antiviral Therapy, v. 17, p. 585-588, 2016. 1359-6535 10.3851/IMP1938 |
url |
https://www.arca.fiocruz.br/handle/icict/15192 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
International Medical Press |
publisher.none.fl_str_mv |
International Medical Press |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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