Arginase 1 is a marker of protection against illness in contacts of leprosy patients

Detalhes bibliográficos
Autor(a) principal: Prata, Rhana Berto da Silva
Data de Publicação: 2022
Outros Autores: Mendes, Mayara Abud, Soares, Vinicius Cardoso, Costa, Jaqueline França, Sales, Ana Maria, Duppre, Nádia Cristina, Borges, Valéria de Matos, Silva, Tatiana Pereira da, Bozza, Patricia Torres, Bozza, Marcelo Torres, Sarno, Euzenir Nunes, Moraes, Milton Ozório, Silva, Gilberto Marcelo Sperandio da, Pinheiro, Roberta Olmo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53364
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Laboratório de Inflamação e Imunidade. Rio de Janeiro, RJ, Brasil.
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spelling Prata, Rhana Berto da SilvaMendes, Mayara AbudSoares, Vinicius CardosoCosta, Jaqueline FrançaSales, Ana MariaDuppre, Nádia CristinaBorges, Valéria de MatosSilva, Tatiana Pereira daBozza, Patricia TorresBozza, Marcelo TorresSarno, Euzenir NunesMoraes, Milton OzórioSilva, Gilberto Marcelo Sperandio daPinheiro, Roberta Olmo2022-06-20T12:26:14Z2022-06-20T12:26:14Z2022PRATA, Rhana Berto da Silva et al. Arginase 1 is a marker of protection against illness in contacts of leprosy patients. Scientific Reports, v. 22, 7850, p. 1 - 9, 2022.2045-2322https://www.arca.fiocruz.br/handle/icict/5336410.1038/s41598-022-11944-9engNature PortfolioArginase 1MarcadorProteção contra doençasPacientes leprososArginase 1Marker of protectionAgainst IllnessLeprosy patientsArginase 1 is a marker of protection against illness in contacts of leprosy patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Laboratório de Inflamação e Imunidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal da Bahia. Hospital Universitário Edgar Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Inflamação e Imunidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilLeprosy household contacts are generally more prone to develop the disease compared to the general population. Previous studies have demonstrated that genes related to the alternative activation (M2) profile in macrophages are associated with the increased bacillary load in multibacillary leprosy patients (MB), and that contacts of MB patients have a higher risk of contracting the disease. In addition, positive serological responses to PGL-1 or LID-1 are associated with a higher risk of disease. We performed a 5-year follow-up of contacts of leprosy patients and evaluated the pattern of gene and protein expression in cells from contacts that developed leprosy during this period. Leprosy household contacts had decreased soluble CD163 and heme oxygenase 1 (HO-1) serum levels when compared with healthy donors and leprosy patients. In contrast, arginase 1 activities were higher in contacts when compared with both healthy donors and leprosy patients. Of the contacts, 33 developed leprosy during the follow-up. Gene expression analysis revealed reduced ARG1 expression in these contacts when compared with contacts that did not develop disease. Arginase activity was a good predictive marker of protection in contacts (sensitivity: 90.0%, specificity: 96.77%) and the association with serology for anti-PGL-1 and anti-LID-1 increased the sensitivity to 100%. Altogether, the data presented here demonstrate a positive role of arginase against leprosy and suggest that the evaluation of arginase activity should be incorporated into leprosy control programs in order to aid in the decision of which contacts should receive chemoprophylaxis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/53364/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRhanaBPrata_MiltonOzorioMoraes_etal_IOC_2022.pdfRhanaBPrata_MiltonOzorioMoraes_etal_IOC_2022.pdfapplication/pdf1061432https://www.arca.fiocruz.br/bitstream/icict/53364/2/RhanaBPrata_MiltonOzorioMoraes_etal_IOC_2022.pdf5e250f9907ed81b9d7a83128299af184MD52icict/533642022-06-24 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dc.title.pt_BR.fl_str_mv Arginase 1 is a marker of protection against illness in contacts of leprosy patients
title Arginase 1 is a marker of protection against illness in contacts of leprosy patients
spellingShingle Arginase 1 is a marker of protection against illness in contacts of leprosy patients
Prata, Rhana Berto da Silva
Arginase 1
Marcador
Proteção contra doenças
Pacientes leprosos
Arginase 1
Marker of protection
Against Illness
Leprosy patients
title_short Arginase 1 is a marker of protection against illness in contacts of leprosy patients
title_full Arginase 1 is a marker of protection against illness in contacts of leprosy patients
title_fullStr Arginase 1 is a marker of protection against illness in contacts of leprosy patients
title_full_unstemmed Arginase 1 is a marker of protection against illness in contacts of leprosy patients
title_sort Arginase 1 is a marker of protection against illness in contacts of leprosy patients
author Prata, Rhana Berto da Silva
author_facet Prata, Rhana Berto da Silva
Mendes, Mayara Abud
Soares, Vinicius Cardoso
Costa, Jaqueline França
Sales, Ana Maria
Duppre, Nádia Cristina
Borges, Valéria de Matos
Silva, Tatiana Pereira da
Bozza, Patricia Torres
Bozza, Marcelo Torres
Sarno, Euzenir Nunes
Moraes, Milton Ozório
Silva, Gilberto Marcelo Sperandio da
Pinheiro, Roberta Olmo
author_role author
author2 Mendes, Mayara Abud
Soares, Vinicius Cardoso
Costa, Jaqueline França
Sales, Ana Maria
Duppre, Nádia Cristina
Borges, Valéria de Matos
Silva, Tatiana Pereira da
Bozza, Patricia Torres
Bozza, Marcelo Torres
Sarno, Euzenir Nunes
Moraes, Milton Ozório
Silva, Gilberto Marcelo Sperandio da
Pinheiro, Roberta Olmo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Prata, Rhana Berto da Silva
Mendes, Mayara Abud
Soares, Vinicius Cardoso
Costa, Jaqueline França
Sales, Ana Maria
Duppre, Nádia Cristina
Borges, Valéria de Matos
Silva, Tatiana Pereira da
Bozza, Patricia Torres
Bozza, Marcelo Torres
Sarno, Euzenir Nunes
Moraes, Milton Ozório
Silva, Gilberto Marcelo Sperandio da
Pinheiro, Roberta Olmo
dc.subject.other.pt_BR.fl_str_mv Arginase 1
Marcador
Proteção contra doenças
Pacientes leprosos
topic Arginase 1
Marcador
Proteção contra doenças
Pacientes leprosos
Arginase 1
Marker of protection
Against Illness
Leprosy patients
dc.subject.en.pt_BR.fl_str_mv Arginase 1
Marker of protection
Against Illness
Leprosy patients
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Laboratório de Inflamação e Imunidade. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-06-20T12:26:14Z
dc.date.available.fl_str_mv 2022-06-20T12:26:14Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PRATA, Rhana Berto da Silva et al. Arginase 1 is a marker of protection against illness in contacts of leprosy patients. Scientific Reports, v. 22, 7850, p. 1 - 9, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53364
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-022-11944-9
identifier_str_mv PRATA, Rhana Berto da Silva et al. Arginase 1 is a marker of protection against illness in contacts of leprosy patients. Scientific Reports, v. 22, 7850, p. 1 - 9, 2022.
2045-2322
10.1038/s41598-022-11944-9
url https://www.arca.fiocruz.br/handle/icict/53364
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Portfolio
publisher.none.fl_str_mv Nature Portfolio
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53364/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/53364/2/RhanaBPrata_MiltonOzorioMoraes_etal_IOC_2022.pdf
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