Zika virus disrupts molecular fingerprinting of human neurospheres
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25590 |
Resumo: | Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biológicas. Rio de Janeiro, RJ, Brasil. |
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Garcez, Patricia P.Nascimento, Juliana MinardiVasconcelos, Janaina Mota deCosta, Rodrigo Madeiro daDelvecchio, RodrigoTrindade, PabloLoiola, Erick CorreiaHiga, Luiza M.Cassoli, Juliana S.Vitória, GabrielaSequeira, Patricia C.Sochacki, JaroslawAguiar, Renato S.Fuzii, Hellen ThaisFilippis, Ana M. Bispo deVianez Júnior, João Lídio da Silva GonçalvesTanuri, AmilcarSouza, Daniel Martins deRehen, Stevens K.2018-04-03T16:44:04Z2018-04-03T16:44:04Z2017GARCEZ, Patrícia P. et al. Zika virus disrupts molecular fingerprinting of human neurospheres. Scientific Reports, v. 23, p. 1-10, Jan. 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/2559010.1038/srep40780engNature Publishing GroupZika virusInfectionMalformações do cérebroMicrocefaliaZika virusInfectionBrain malformationsMicrocephalyZika virus disrupts molecular fingerprinting of human neurospheresinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto D´Or de Pesquisa e Educação. Rio de Janeiro, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biológicas. Rio de Janeiro, RJ, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, Brasil / Universidade de Campinas. Departamento de Bioquímica e Biologia Tecidual. Campinas, SP, Brasil.Instituto Evandro Chagas. Centro de Inovação Tecnológica. Belém, PA, BrasilInstituto D´Or de Pesquisa e Educação. Rio de Janeiro, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Rio de Janeiro, RJ, BrasilInstituto D´Or de Pesquisa e Educação. Rio de Janeiro, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Rio de Janeiro, RJ, BrasilUniversidade de Campinas. Departamento de Bioquímica e Biologia Tecidual. Campinas, SP, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz Fiocruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Rio de Janeiro, RJ, BrasilUniversidade Federal do Pará. Belém, PA, Brasil.Fundação Oswaldo Cruz Fiocruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Instituto Evandro Chagas. Centro de Inovação Tecnológica. Belém, PA, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biologia. Rio de Janeiro, RJ, BrasilUniversidade de Campinas. Departamento de Bioquímica e Biologia Tecidual. Campinas, SP, Brasil.Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biológicas. Rio de Janeiro, RJ, Brasil.Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is circulating in Brazil. Combining proteomics and mRNA transcriptional profiling, over 500 proteins and genes associated with the Brazilian ZIKV infection were found to be differentially expressed. These genes and proteins provide an interactome map, which indicates that ZIKV controls the expression of RNA processing bodies, miRNA biogenesis and splicing factors required for self-replication. It also suggests that impairments in the molecular pathways underpinning cell cycle and neuronal differentiation are caused by ZIKV. These results point to biological mechanisms implicated in brain malformations, which are important to further the understanding of ZIKV infection and can be exploited as therapeutic potential targets to mitigate it.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25590/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALanamariab_filippis_etal_IOC_2017.pdfanamariab_filippis_etal_IOC_2017.pdfapplication/pdf1347352https://www.arca.fiocruz.br/bitstream/icict/25590/2/anamariab_filippis_etal_IOC_2017.pdfb3a68b2d8ea28413682153a717faa4c4MD52TEXTanamariab_filippis_etal_IOC_2017.pdf.txtanamariab_filippis_etal_IOC_2017.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Zika virus disrupts molecular fingerprinting of human neurospheres |
| title |
Zika virus disrupts molecular fingerprinting of human neurospheres |
| spellingShingle |
Zika virus disrupts molecular fingerprinting of human neurospheres Garcez, Patricia P. Zika virus Infection Malformações do cérebro Microcefalia Zika virus Infection Brain malformations Microcephaly |
| title_short |
Zika virus disrupts molecular fingerprinting of human neurospheres |
| title_full |
Zika virus disrupts molecular fingerprinting of human neurospheres |
| title_fullStr |
Zika virus disrupts molecular fingerprinting of human neurospheres |
| title_full_unstemmed |
Zika virus disrupts molecular fingerprinting of human neurospheres |
| title_sort |
Zika virus disrupts molecular fingerprinting of human neurospheres |
| author |
Garcez, Patricia P. |
| author_facet |
Garcez, Patricia P. Nascimento, Juliana Minardi Vasconcelos, Janaina Mota de Costa, Rodrigo Madeiro da Delvecchio, Rodrigo Trindade, Pablo Loiola, Erick Correia Higa, Luiza M. Cassoli, Juliana S. Vitória, Gabriela Sequeira, Patricia C. Sochacki, Jaroslaw Aguiar, Renato S. Fuzii, Hellen Thais Filippis, Ana M. Bispo de Vianez Júnior, João Lídio da Silva Gonçalves Tanuri, Amilcar Souza, Daniel Martins de Rehen, Stevens K. |
| author_role |
author |
| author2 |
Nascimento, Juliana Minardi Vasconcelos, Janaina Mota de Costa, Rodrigo Madeiro da Delvecchio, Rodrigo Trindade, Pablo Loiola, Erick Correia Higa, Luiza M. Cassoli, Juliana S. Vitória, Gabriela Sequeira, Patricia C. Sochacki, Jaroslaw Aguiar, Renato S. Fuzii, Hellen Thais Filippis, Ana M. Bispo de Vianez Júnior, João Lídio da Silva Gonçalves Tanuri, Amilcar Souza, Daniel Martins de Rehen, Stevens K. |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Garcez, Patricia P. Nascimento, Juliana Minardi Vasconcelos, Janaina Mota de Costa, Rodrigo Madeiro da Delvecchio, Rodrigo Trindade, Pablo Loiola, Erick Correia Higa, Luiza M. Cassoli, Juliana S. Vitória, Gabriela Sequeira, Patricia C. Sochacki, Jaroslaw Aguiar, Renato S. Fuzii, Hellen Thais Filippis, Ana M. Bispo de Vianez Júnior, João Lídio da Silva Gonçalves Tanuri, Amilcar Souza, Daniel Martins de Rehen, Stevens K. |
| dc.subject.other.pt_BR.fl_str_mv |
Zika virus Infection Malformações do cérebro Microcefalia |
| topic |
Zika virus Infection Malformações do cérebro Microcefalia Zika virus Infection Brain malformations Microcephaly |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus Infection Brain malformations Microcephaly |
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Instituto D´Or de Pesquisa e Educação. Rio de Janeiro, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biológicas. Rio de Janeiro, RJ, Brasil. |
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2017 |
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2017 |
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2018-04-03T16:44:04Z |
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2018-04-03T16:44:04Z |
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GARCEZ, Patrícia P. et al. Zika virus disrupts molecular fingerprinting of human neurospheres. Scientific Reports, v. 23, p. 1-10, Jan. 2017. |
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https://www.arca.fiocruz.br/handle/icict/25590 |
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2045-2322 |
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10.1038/srep40780 |
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GARCEZ, Patrícia P. et al. Zika virus disrupts molecular fingerprinting of human neurospheres. Scientific Reports, v. 23, p. 1-10, Jan. 2017. 2045-2322 10.1038/srep40780 |
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Nature Publishing Group |
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Nature Publishing Group |
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