Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria

Detalhes bibliográficos
Autor(a) principal: Mendonça, Vitor Rosa Ramos de
Data de Publicação: 2012
Outros Autores: Andrade, Bruno de Bezerril, Souza, Ligia Correia Lima de, Garcia, Gabriela Barreto Caldas, Queiroz, Artur Trancoso Lopo de, Gonçalves, Marilda de Souza, Barral Netto, Manoel
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23786
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
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spelling Mendonça, Vitor Rosa Ramos deAndrade, Bruno de BezerrilSouza, Ligia Correia Lima deGarcia, Gabriela Barreto CaldasQueiroz, Artur Trancoso Lopo deGonçalves, Marilda de SouzaBarral Netto, Manoel2017-12-27T14:32:24Z2017-12-27T14:32:24Z2012MENDONÇA, V. R. R. M. et al. Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.https://www.arca.fiocruz.br/handle/icict/23786engSociedade Brasileira de Medicina TropicalMaláriaMutaçõesGeneVolume plasmáticoProteínasMalariaMutationGenePlasma volumeProteinMutations in SOD-1 gene are associated with different protein expression and susceptibility to malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.National Institute of Allergy and Infectious Diseases National Institutes of Health. Laboratory of Parasitic Diseases,Immunobiology Section. Bethesda, MD, USA.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. São Paulo, SP, Brasil.Introduction: During malaria, intense inflammation results in oxidative stress, and superoxide anions are the main reactive oxygen species produced. Cu/Zn superoxide dismutase (SOD1) is a key enzyme that, in together with catalase and glutathione peroxidase, scavenges superoxide anions and protects cells from oxidative damage. We have previously shown that SOD1 plasma levels are elevated in vivax malaria and that this enzyme can be used as a reliable biomarker for severe disease. Here, we test whether mutations in SOD1 gene (exon 1) and a Single Nucleotide Polymorphism (SNP) -308 (G>A) in the TNFalpha gene are associated with susceptibility to vivax malaria.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23786/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMendonça VRR Mutations...SBMT 2012 Mal018.pdfMendonça VRR Mutations...SBMT 2012 Mal018.pdfapplication/pdf71330https://www.arca.fiocruz.br/bitstream/icict/23786/2/Mendon%c3%a7a%20VRR%20Mutations...SBMT%202012%20Mal018.pdf1559ff5f875a86274e2ea785e3afde73MD52TEXTMendonça VRR Mutations...SBMT 2012 Mal018.pdf.txtMendonça VRR Mutations...SBMT 2012 Mal018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria
title Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria
spellingShingle Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria
Mendonça, Vitor Rosa Ramos de
Malária
Mutações
Gene
Volume plasmático
Proteínas
Malaria
Mutation
Gene
Plasma volume
Protein
title_short Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria
title_full Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria
title_fullStr Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria
title_full_unstemmed Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria
title_sort Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria
author Mendonça, Vitor Rosa Ramos de
author_facet Mendonça, Vitor Rosa Ramos de
Andrade, Bruno de Bezerril
Souza, Ligia Correia Lima de
Garcia, Gabriela Barreto Caldas
Queiroz, Artur Trancoso Lopo de
Gonçalves, Marilda de Souza
Barral Netto, Manoel
author_role author
author2 Andrade, Bruno de Bezerril
Souza, Ligia Correia Lima de
Garcia, Gabriela Barreto Caldas
Queiroz, Artur Trancoso Lopo de
Gonçalves, Marilda de Souza
Barral Netto, Manoel
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendonça, Vitor Rosa Ramos de
Andrade, Bruno de Bezerril
Souza, Ligia Correia Lima de
Garcia, Gabriela Barreto Caldas
Queiroz, Artur Trancoso Lopo de
Gonçalves, Marilda de Souza
Barral Netto, Manoel
dc.subject.other.pt_BR.fl_str_mv Malária
Mutações
Gene
Volume plasmático
Proteínas
topic Malária
Mutações
Gene
Volume plasmático
Proteínas
Malaria
Mutation
Gene
Plasma volume
Protein
dc.subject.en.pt_BR.fl_str_mv Malaria
Mutation
Gene
Plasma volume
Protein
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-12-27T14:32:24Z
dc.date.available.fl_str_mv 2017-12-27T14:32:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENDONÇA, V. R. R. M. et al. Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23786
identifier_str_mv MENDONÇA, V. R. R. M. et al. Mutations in SOD-1 gene are associated with different protein expression and susceptibility to malaria. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.
url https://www.arca.fiocruz.br/handle/icict/23786
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/23786/1/license.txt
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