Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death

Detalhes bibliográficos
Autor(a) principal: Van Weyenbergh, Johan Jozef Rosa Maria
Data de Publicação: 2001
Outros Autores: Wietzerbin, Juana, Rouillard, Dany, Barral Netto, Manoel, Liblau, Roland
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7440
Resumo: INSERM. Paris, França
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spelling Van Weyenbergh, Johan Jozef Rosa MariaWietzerbin, JuanaRouillard, DanyBarral Netto, ManoelLiblau, Roland2014-03-24T17:46:43Z2014-03-24T17:46:43Z2001VAN WEYENBERGH, J. et al. Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death. Journal of Leukocyte Biology, v. 70, p.745-748, 2001.0741-5400https://www.arca.fiocruz.br/handle/icict/7440engWiley-LissTreatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell deathinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleINSERM. Paris, FrançaINSERM. Paris, FrançaInstitut Curie. Section de Recherche. Paris, FrançaFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilAlthough interferon (IFN)-b has shown a significant clinical benefit in multiple sclerosis (MS), its mechanism of action remains unclear. We found that IFN-b treatment of patients with MS resulted in a significant increase in apoptotic cell death (measured by annexin V staining and nuclear fragmentation) of monocyte-derived macrophages, as compared with cells derived from patients before treatment. Stimulation of the cells with IFN-b in vitro resulted in an even further increase of annexin V binding, as well as increased Fas (CD 95, APO-1) expression. However, no increased Fas expression, apoptotic monocytes, or monocytopenia were observed upon in vivo treatment. This indicates that IFN-b does not deliver a death signal to monocytes but rather primes for subsequent macrophage apoptosis upon activation or differentiationIn vivoCD 14CD 64CD 95 (Fas)ApoptoseFatores Imunológicos/uso terapêuticoInterferon beta/uso terapêuticoMacrófagos/patologiaEsclerose Múltipla/quimioterapiaAdultoAnexina A5/metabolismoAntígenos CD95/biossínteseAntígenos CD95/genéticaApoptose/efeitos de drogasLinhagem da CélulaFemininoHumanosFatores Imunológicos/farmacologiaInterferon beta/farmacologiaAtivação de MacrófagosMacrófagos/efeitos de drogasMacrófagos/metabolismoMasculinoMeia-IdadeMonócitos/efeitos de drogasMonócitos/metabolismoEsclerose Múltipla/imunologiaEsclerose Múltipla/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALVan Weyenbergh J Treatment of multiple....pdfVan Weyenbergh J Treatment of multiple....pdfapplication/pdf177035https://www.arca.fiocruz.br/bitstream/icict/7440/1/Van%20Weyenbergh%20J%20Treatment%20of%20multiple....pdfe34a48be36ad1034ddfea20d2289a1d4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7440/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTVan Weyenbergh J Treatment of multiple....pdf.txtVan Weyenbergh J Treatment of multiple....pdf.txtExtracted texttext/plain17435https://www.arca.fiocruz.br/bitstream/icict/7440/5/Van%20Weyenbergh%20J%20Treatment%20of%20multiple....pdf.txtd94b68df2c3d9aeb980656ec23fc2d05MD55THUMBNAILVan Weyenbergh J Treatment of multiple....pdf.jpgVan Weyenbergh J Treatment of multiple....pdf.jpgGenerated Thumbnailimage/jpeg2547https://www.arca.fiocruz.br/bitstream/icict/7440/4/Van%20Weyenbergh%20J%20Treatment%20of%20multiple....pdf.jpge1048a50ff949b2e4046e7ee73b682a2MD54icict/74402023-03-15 14:33:22.857oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death
title Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death
spellingShingle Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death
Van Weyenbergh, Johan Jozef Rosa Maria
In vivo
CD 14
CD 64
CD 95 (Fas)
Apoptose
Fatores Imunológicos/uso terapêutico
Interferon beta/uso terapêutico
Macrófagos/patologia
Esclerose Múltipla/quimioterapia
Adulto
Anexina A5/metabolismo
Antígenos CD95/biossíntese
Antígenos CD95/genética
Apoptose/efeitos de drogas
Linhagem da Célula
Feminino
Humanos
Fatores Imunológicos/farmacologia
Interferon beta/farmacologia
Ativação de Macrófagos
Macrófagos/efeitos de drogas
Macrófagos/metabolismo
Masculino
Meia-Idade
Monócitos/efeitos de drogas
Monócitos/metabolismo
Esclerose Múltipla/imunologia
Esclerose Múltipla/patologia
title_short Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death
title_full Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death
title_fullStr Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death
title_full_unstemmed Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death
title_sort Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death
author Van Weyenbergh, Johan Jozef Rosa Maria
author_facet Van Weyenbergh, Johan Jozef Rosa Maria
Wietzerbin, Juana
Rouillard, Dany
Barral Netto, Manoel
Liblau, Roland
author_role author
author2 Wietzerbin, Juana
Rouillard, Dany
Barral Netto, Manoel
Liblau, Roland
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Van Weyenbergh, Johan Jozef Rosa Maria
Wietzerbin, Juana
Rouillard, Dany
Barral Netto, Manoel
Liblau, Roland
dc.subject.en.pt_BR.fl_str_mv In vivo
CD 14
CD 64
CD 95 (Fas)
topic In vivo
CD 14
CD 64
CD 95 (Fas)
Apoptose
Fatores Imunológicos/uso terapêutico
Interferon beta/uso terapêutico
Macrófagos/patologia
Esclerose Múltipla/quimioterapia
Adulto
Anexina A5/metabolismo
Antígenos CD95/biossíntese
Antígenos CD95/genética
Apoptose/efeitos de drogas
Linhagem da Célula
Feminino
Humanos
Fatores Imunológicos/farmacologia
Interferon beta/farmacologia
Ativação de Macrófagos
Macrófagos/efeitos de drogas
Macrófagos/metabolismo
Masculino
Meia-Idade
Monócitos/efeitos de drogas
Monócitos/metabolismo
Esclerose Múltipla/imunologia
Esclerose Múltipla/patologia
dc.subject.decs.pt_BR.fl_str_mv Apoptose
Fatores Imunológicos/uso terapêutico
Interferon beta/uso terapêutico
Macrófagos/patologia
Esclerose Múltipla/quimioterapia
Adulto
Anexina A5/metabolismo
Antígenos CD95/biossíntese
Antígenos CD95/genética
Apoptose/efeitos de drogas
Linhagem da Célula
Feminino
Humanos
Fatores Imunológicos/farmacologia
Interferon beta/farmacologia
Ativação de Macrófagos
Macrófagos/efeitos de drogas
Macrófagos/metabolismo
Masculino
Meia-Idade
Monócitos/efeitos de drogas
Monócitos/metabolismo
Esclerose Múltipla/imunologia
Esclerose Múltipla/patologia
description INSERM. Paris, França
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2014-03-24T17:46:43Z
dc.date.available.fl_str_mv 2014-03-24T17:46:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VAN WEYENBERGH, J. et al. Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death. Journal of Leukocyte Biology, v. 70, p.745-748, 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7440
dc.identifier.issn.none.fl_str_mv 0741-5400
identifier_str_mv VAN WEYENBERGH, J. et al. Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death. Journal of Leukocyte Biology, v. 70, p.745-748, 2001.
0741-5400
url https://www.arca.fiocruz.br/handle/icict/7440
dc.language.iso.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-Liss
publisher.none.fl_str_mv Wiley-Liss
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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