Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry')

Detalhes bibliográficos
Autor(a) principal: Erton, Zeynep Belce
Data de Publicação: 2022
Outros Autores: Sevim, Ecem, Jesús, Guilherme Ramires de, Cervera, Ricard, Lanlan, Ji, Pengo, Vittorio, Ugarte, Amaia, Andrade, Danieli, Andreoli, Laura, Tatsuya, Atsumi, Fortin, Paul R., Gerosa, Maria, Yu, Zuo, Petri, Michelle, Sciascia, Savino, Tektonidou, Maria G., Aguirre-Zamorano, Maria Angeles, Branch, D. Ware, Erkan, Doruk
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55069
Resumo: Hospital for Special Surgery. Divison of Rheumatology. New York, NY, USA
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spelling Erton, Zeynep BelceSevim, EcemJesús, Guilherme Ramires deCervera, RicardLanlan, JiPengo, VittorioUgarte, AmaiaAndrade, DanieliAndreoli, LauraTatsuya, AtsumiFortin, Paul R.Gerosa, MariaYu, ZuoPetri, MichelleSciascia, SavinoTektonidou, Maria G.Aguirre-Zamorano, Maria AngelesBranch, D. WareErkan, Doruk2022-10-10T14:05:53Z2022-10-10T14:05:53Z2022ERTON, Zeynep Belce et al. Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry'). Lupus Science & Medicine, v. 9, n. e000633, p. 1-10, 14 June 2022.2053-8790https://www.arca.fiocruz.br/handle/icict/5506910.1136/lupus-2021-0006332053-8790engBMJ Publishing GroupPregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry')info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital for Special Surgery. Divison of Rheumatology. New York, NY, USAYeshiva University. Albert Einstein College of Medicine. Bronx, NY, USA / Montefiore Medical Center. Internal Medicine. Bronx, NY, USA.Universidade do Estado do Rio de Janeiro. Centro Biomédico. Faculdade de Ciências Médicas. Departamento de Ginecologia e Obstetrícia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Institut Clínic de Medicina i Dermatologia. Hospital Clínic de Barcelona. Autoimmune Diseases. Barcelona, Spain.Peking University First Hospital. Department of Rheumatology and Clinical Immunology. Beijing, Beijing, China.University of Padova. Cardiac Thoracic and Vascular Sciences. Padua, Italy.Hospital de Cruces. Internal Medicine. Barkaldo, Spain.Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil.University of Brescia. Department of Clinical and Experimental Sciences. Brescia, Italy / ASST Spedali Civili di Brescia. Unit of Rheumatology and Clinical Immunology. Brescia, Italy.Hokkaido University. School of Medicine. Medicine II. Sapporo, Japan.Centre Hospitalier de l’Université Laval. Medicine - Rheumatology. Quebec City, Quebec, Canada.University of Milano. Division of Rheumatology. Dept. of Clinical & Community Science. Milano, Italy.University of Michigan. Internal Medicine/Division of Rheumatology. Ann Arbor, Michigan, USA.Johns Hopkins University. Rheumatology. Baltimore, Maryland, USA.Università di Torino. Ospedale Torino Nord Emergenza San G. Bosco. Struttura Complessa a Direzione Universitaria di Immunologia Clinica. Centro di Ricerche di Immunopatologia e Documentazione su Malattie Rare. Dipartimento di Malattie Rare, Immunologiche, Ematologiche ed Immunoematologiche. Torino, Italy.National and Kapodistrian University of Athens. First Department of Propaedeutic Internal Medicine. Athens, Greece.University Hospital “Reina Sofia”. Rheumatology. Cordoba, Spain.University of Utah. Health Sciences Center. Maternal-Fetal Medicine. Salt Lake City, Utah, USA / Intermountain Healthcare. Maternal-Fetal Medicine. Salt Lake City, Utah, USA.Weill Cornell Medicine. Hospital for Special Surgery. Barbara Volcker Center for Women and Rheumatic Diseases. Rheumatology. New York, NY, USA.Objectives: To describe the outcomes of pregnancies in antiphospholipid antibody (aPL)-positive patients since the inception of the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking Registry. Methods: We identified persistently aPL-positive patients recorded as ‘pregnant’ during prospective follow-up, and defined ‘aPL-related outcome’ as a composite of: (1) Preterm live delivery (PTLD) at or before 37th week due to pre-eclampsia (PEC), eclampsia, small-for-gestational age (SGA) and/or placental insufficiency (PI); or (2) Otherwise unexplained fetal death after the 10th week of gestation. The primary objective was to describe the characteristics of patients with and without aPL-related composite outcomes based on their first observed pregnancies following registry recruitment. Results: Of the 55 first pregnancies observed after registry recruitment among nulliparous and multiparous participants, 15 (27%) resulted in early pregnancy loss <10 weeks gestation. Of the remaining 40 pregnancies: (1) 26 (65%) resulted in term live delivery (TLD), 4 (10%) in PTLD between 34.0 weeks and 36.6 weeks, 5 (12.5%) in PTLD before 34th week, and 5 (12.5%) in fetal death (two associated with genetic anomalies); and (2) The aPL-related composite outcome occurred in 9 (23%). One of 26 (4%) pregnancies with TLD, 3/4 (75%) with PTLD between 34.0 weeks and 36.6 weeks, and 3/5 (60%) with PTLD before 34th week were complicated with PEC, SGA and/or PI. Fifty of 55 (91%) pregnancies were in lupus anticoagulant positive subjects, as well as all pregnancies with aPL-related composite outcome. Conclusion: In our multicentre, international, aPL-positive cohort, of 55 first pregnancies observed prospectively, 15 (27%) were complicated by early pregnancy loss. Of the remaining 40 pregnancies, composite pregnancy morbidity was observed in 9 (23%) pregnancies.AntiPhospholipid SyndromeAPS ACTIONFetal deathPregnancy lossDemographics featuresClinical featuresinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPregnancy outcomes in antiphospholipid antibody positive patients.pdfPregnancy outcomes in antiphospholipid antibody positive patients.pdfapplication/pdf597403https://www.arca.fiocruz.br/bitstream/icict/55069/2/Pregnancy%20outcomes%20in%20antiphospholipid%20antibody%20positive%20patients.pdf3ab6204f8d30744f6ccf5e17dd3c0c4cMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-83132https://www.arca.fiocruz.br/bitstream/icict/55069/1/license.txt33967fcc8ef681b8f5c2c34178ebc114MD51icict/550692022-10-10 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dc.title.en_US.fl_str_mv Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry')
title Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry')
spellingShingle Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry')
Erton, Zeynep Belce
AntiPhospholipid Syndrome
APS ACTION
Fetal death
Pregnancy loss
Demographics features
Clinical features
title_short Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry')
title_full Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry')
title_fullStr Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry')
title_full_unstemmed Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry')
title_sort Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry')
author Erton, Zeynep Belce
author_facet Erton, Zeynep Belce
Sevim, Ecem
Jesús, Guilherme Ramires de
Cervera, Ricard
Lanlan, Ji
Pengo, Vittorio
Ugarte, Amaia
Andrade, Danieli
Andreoli, Laura
Tatsuya, Atsumi
Fortin, Paul R.
Gerosa, Maria
Yu, Zuo
Petri, Michelle
Sciascia, Savino
Tektonidou, Maria G.
Aguirre-Zamorano, Maria Angeles
Branch, D. Ware
Erkan, Doruk
author_role author
author2 Sevim, Ecem
Jesús, Guilherme Ramires de
Cervera, Ricard
Lanlan, Ji
Pengo, Vittorio
Ugarte, Amaia
Andrade, Danieli
Andreoli, Laura
Tatsuya, Atsumi
Fortin, Paul R.
Gerosa, Maria
Yu, Zuo
Petri, Michelle
Sciascia, Savino
Tektonidou, Maria G.
Aguirre-Zamorano, Maria Angeles
Branch, D. Ware
Erkan, Doruk
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Erton, Zeynep Belce
Sevim, Ecem
Jesús, Guilherme Ramires de
Cervera, Ricard
Lanlan, Ji
Pengo, Vittorio
Ugarte, Amaia
Andrade, Danieli
Andreoli, Laura
Tatsuya, Atsumi
Fortin, Paul R.
Gerosa, Maria
Yu, Zuo
Petri, Michelle
Sciascia, Savino
Tektonidou, Maria G.
Aguirre-Zamorano, Maria Angeles
Branch, D. Ware
Erkan, Doruk
dc.subject.en.en_US.fl_str_mv AntiPhospholipid Syndrome
APS ACTION
Fetal death
Pregnancy loss
Demographics features
Clinical features
topic AntiPhospholipid Syndrome
APS ACTION
Fetal death
Pregnancy loss
Demographics features
Clinical features
description Hospital for Special Surgery. Divison of Rheumatology. New York, NY, USA
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-10T14:05:53Z
dc.date.available.fl_str_mv 2022-10-10T14:05:53Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ERTON, Zeynep Belce et al. Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry'). Lupus Science & Medicine, v. 9, n. e000633, p. 1-10, 14 June 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55069
dc.identifier.issn.en_US.fl_str_mv 2053-8790
dc.identifier.doi.none.fl_str_mv 10.1136/lupus-2021-000633
dc.identifier.eissn.none.fl_str_mv 2053-8790
identifier_str_mv ERTON, Zeynep Belce et al. Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry'). Lupus Science & Medicine, v. 9, n. e000633, p. 1-10, 14 June 2022.
2053-8790
10.1136/lupus-2021-000633
url https://www.arca.fiocruz.br/handle/icict/55069
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55069/2/Pregnancy%20outcomes%20in%20antiphospholipid%20antibody%20positive%20patients.pdf
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