Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction

Detalhes bibliográficos
Autor(a) principal: Temporal, R. M.
Data de Publicação: 2005
Outros Autores: Cysne-Finkelstein, L., Echevarria, A., Gonçalves, A. J. Silva, Leon, L. L., Genestra, M. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/38022
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
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spelling Temporal, R. M.Cysne-Finkelstein, L.Echevarria, A.Gonçalves, A. J. SilvaLeon, L. L.Genestra, M. S.2019-12-17T11:27:26Z2019-12-17T11:27:26Z2005TEMPORAL, R. M. et al. Amidine Derivatives and Leishmania amazonensis: an Evaluation of the Effect of Nitric Oxide (NO) Production on the Parasite-macrophage Interaction. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 20, n. 1, p. 13-18, Feb. 2005.1475-6366https://www.arca.fiocruz.br/handle/icict/3802210.1080/147563604000152071475-6374engTaylor & FrancisLeishmania amazonensisÓxido NítricoÓxido Nítrico SintasePentamidinaAmidinaLeishmania amazonensisNitric oxideNitric oxide synthasePentamidineMethoxy-amidineAmidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interactioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Departamento de Química. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Previous work has demonstrated that N-N'-diphenyl-R-benzamidine was highly effective against Leishmania amazonensis promastigotes/axenic amastigotes and Trypanosoma evansi trypomastigotes and the compound with a methoxy substituent, was the most effective derivative in the parasite-macrophage interaction. Comparative analysis of the nitric oxide (NO) released from the culture infection's supernatant showed the amidine to be less effective than pentamidine Isethionate as a reference drug. Additionally, in order to verify if the methoxylated derivative interferes with NO production by L. amazonensis, the effect of the amidine on the constitutive nitric oxide synthase (cNOS) purified from parasites, was examined, but demonstrated less activity in comparison with the reference drug. This data contributes to studies concerning the metabolic targets present in Leishmania parasites for leishmanicidal drugs.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/38022/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRM_Temporal_etal_IOC_2005.pdfRM_Temporal_etal_IOC_2005.pdfapplication/pdf408055https://www.arca.fiocruz.br/bitstream/icict/38022/2/RM_Temporal_etal_IOC_2005.pdfc93f1871cc8d38d92b4333b26a76198bMD52TEXTRM_Temporal_etal_IOC_2005.pdf.txtRM_Temporal_etal_IOC_2005.pdf.txtExtracted texttext/plain24833https://www.arca.fiocruz.br/bitstream/icict/38022/3/RM_Temporal_etal_IOC_2005.pdf.txt6af1f5f0dbf6596dbcb4da3b0cea89beMD53icict/380222019-12-18 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dc.title.pt_BR.fl_str_mv Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction
title Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction
spellingShingle Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction
Temporal, R. M.
Leishmania amazonensis
Óxido Nítrico
Óxido Nítrico Sintase
Pentamidina
Amidina
Leishmania amazonensis
Nitric oxide
Nitric oxide synthase
Pentamidine
Methoxy-amidine
title_short Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction
title_full Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction
title_fullStr Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction
title_full_unstemmed Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction
title_sort Amidine derivatives and Leishmania amazonensis: an evaluation of the effect of nitric oxide (NO) production on the parasite-macrophage interaction
author Temporal, R. M.
author_facet Temporal, R. M.
Cysne-Finkelstein, L.
Echevarria, A.
Gonçalves, A. J. Silva
Leon, L. L.
Genestra, M. S.
author_role author
author2 Cysne-Finkelstein, L.
Echevarria, A.
Gonçalves, A. J. Silva
Leon, L. L.
Genestra, M. S.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Temporal, R. M.
Cysne-Finkelstein, L.
Echevarria, A.
Gonçalves, A. J. Silva
Leon, L. L.
Genestra, M. S.
dc.subject.other.pt_BR.fl_str_mv Leishmania amazonensis
Óxido Nítrico
Óxido Nítrico Sintase
Pentamidina
Amidina
topic Leishmania amazonensis
Óxido Nítrico
Óxido Nítrico Sintase
Pentamidina
Amidina
Leishmania amazonensis
Nitric oxide
Nitric oxide synthase
Pentamidine
Methoxy-amidine
dc.subject.en.pt_BR.fl_str_mv Leishmania amazonensis
Nitric oxide
Nitric oxide synthase
Pentamidine
Methoxy-amidine
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2019-12-17T11:27:26Z
dc.date.available.fl_str_mv 2019-12-17T11:27:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TEMPORAL, R. M. et al. Amidine Derivatives and Leishmania amazonensis: an Evaluation of the Effect of Nitric Oxide (NO) Production on the Parasite-macrophage Interaction. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 20, n. 1, p. 13-18, Feb. 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/38022
dc.identifier.issn.pt_BR.fl_str_mv 1475-6366
dc.identifier.doi.none.fl_str_mv 10.1080/14756360400015207
dc.identifier.eissn.none.fl_str_mv 1475-6374
identifier_str_mv TEMPORAL, R. M. et al. Amidine Derivatives and Leishmania amazonensis: an Evaluation of the Effect of Nitric Oxide (NO) Production on the Parasite-macrophage Interaction. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 20, n. 1, p. 13-18, Feb. 2005.
1475-6366
10.1080/14756360400015207
1475-6374
url https://www.arca.fiocruz.br/handle/icict/38022
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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