Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis

Detalhes bibliográficos
Autor(a) principal: Silva, Vicente Rezende
Data de Publicação: 2021
Outros Autores: Neves, Eula Graciele Amorin, Passos, Lívia Silva Araújo, Melo, Flávia Cristina de, Carvalho, Andrea Teixeira de, Nassif, Maria Cecília Landim, Junqueira, Lucas Lodi, Aikawa, Elena, Dutra, Walderez Ornelas, Nunes, Maria Carmo Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51176
Resumo: Post Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
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spelling Silva, Vicente RezendeNeves, Eula Graciele AmorinPassos, Lívia Silva AraújoMelo, Flávia Cristina deCarvalho, Andrea Teixeira deNassif, Maria Cecília LandimJunqueira, Lucas LodiAikawa, ElenaDutra, Walderez OrnelasNunes, Maria Carmo Pereira2022-02-14T15:35:47Z2022-02-14T15:35:47Z2021SILVA, Vicente Rezende et al. Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis. Front Cardiovasc Med., v. 7, 604826, 2021. doi: 10.3389/fcvm.2020.604826. eCollection 2020.2297-055Xhttps://www.arca.fiocruz.br/handle/icict/51176engFrontiers Media S.ADecreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePost Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/ Department of Cardiovascular Medicine. The Center for Excellence in Vascular Biology. Brigham and Women's Hospital. Harvard Medical School. Boston, MA, United States.Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Cardiologia e Cirurgia Cardiovascular. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Cardiologia e Cirurgia Cardiovascular. Belo Horizonte, MG, Brazil.Department of Cardiovascular Medicine. The Center for Excellence in Vascular Biology. Brigham and Women's Hospital. Harvard Medical School. Boston, MA, United States.Post Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil./Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brazil.Post Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Cardiologia e Cirurgia Cardiovascular. Belo Horizonte, MG, Brazil.Mitral stenosis (MS) is a consequence of rheumatic heart disease that leads to heart failure requiring mechanical intervention. Percutaneous mitral commissurotomy (PMC) is the treatment of choice for the intervention, and currently there are no soluble markers associated with hemodynamic improvement after PMC. This study aims to determine the changes in cytokine/chemokine plasma levels, as well as T cell activation after PMC, and to investigate their association with immediate hemodynamic improvement and clinical outcomes. Plasma samples from eighteen patients with well-defined MS who underwent PMC and 12 healthy controls were analyzed using BioPlex immunoassay. We observed that 16 out of the 27 (60%) molecules assessed were altered in patients\' plasma pre-PMC as compared to control group. Of those, IL-1 beta, IL-12, IL-6, IL-4, PDGF, and CCL11 showed significant decrease after PMC. Stratifying the patients according to adverse outcome after a 28-month median follow up, we detected a significant reduction of IL-1 beta, IL-12, IL-6, IL-4, IFN-gamma, CXCL-10, VEGF, FGF and PDGF post-PMC in patients without events, but not in those who presented adverse events during the follow-up. Patients with adverse outcomes had lower IL-10 pre-PMC, as compared to the ones without adverse events. In addition, the frequency of CD8+ activated memory cells was increased after PMC, while the frequency of CD4+ activated memory cells did not change. Our results show an association between the decrease of specific cytokines and changes in T cell activation with hemodynamic improvement post-PMC, as well as with long-term outcomes, suggesting their possible use as soluble markers for hemodynamic recovery after MS intervention.T cellscytokinesmitral stenosispercutaneous mitral commissurotomyrheumatic heart diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51176/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALDecreased Cytokine Plasma Levels and Changes .pdfDecreased Cytokine Plasma Levels and Changes .pdfapplication/pdf1361671https://www.arca.fiocruz.br/bitstream/icict/51176/2/Decreased%20Cytokine%20Plasma%20Levels%20and%20Changes%20.pdf3bbcdb29763087d93a9535e5b1cffec2MD52icict/511762022-02-14 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dc.title.pt_BR.fl_str_mv Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
title Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
spellingShingle Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
Silva, Vicente Rezende
T cells
cytokines
mitral stenosis
percutaneous mitral commissurotomy
rheumatic heart disease
title_short Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
title_full Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
title_fullStr Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
title_full_unstemmed Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
title_sort Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
author Silva, Vicente Rezende
author_facet Silva, Vicente Rezende
Neves, Eula Graciele Amorin
Passos, Lívia Silva Araújo
Melo, Flávia Cristina de
Carvalho, Andrea Teixeira de
Nassif, Maria Cecília Landim
Junqueira, Lucas Lodi
Aikawa, Elena
Dutra, Walderez Ornelas
Nunes, Maria Carmo Pereira
author_role author
author2 Neves, Eula Graciele Amorin
Passos, Lívia Silva Araújo
Melo, Flávia Cristina de
Carvalho, Andrea Teixeira de
Nassif, Maria Cecília Landim
Junqueira, Lucas Lodi
Aikawa, Elena
Dutra, Walderez Ornelas
Nunes, Maria Carmo Pereira
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Vicente Rezende
Neves, Eula Graciele Amorin
Passos, Lívia Silva Araújo
Melo, Flávia Cristina de
Carvalho, Andrea Teixeira de
Nassif, Maria Cecília Landim
Junqueira, Lucas Lodi
Aikawa, Elena
Dutra, Walderez Ornelas
Nunes, Maria Carmo Pereira
dc.subject.en.pt_BR.fl_str_mv T cells
cytokines
mitral stenosis
percutaneous mitral commissurotomy
rheumatic heart disease
topic T cells
cytokines
mitral stenosis
percutaneous mitral commissurotomy
rheumatic heart disease
description Post Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-14T15:35:47Z
dc.date.available.fl_str_mv 2022-02-14T15:35:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Vicente Rezende et al. Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis. Front Cardiovasc Med., v. 7, 604826, 2021. doi: 10.3389/fcvm.2020.604826. eCollection 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51176
dc.identifier.issn.pt_BR.fl_str_mv 2297-055X
identifier_str_mv SILVA, Vicente Rezende et al. Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis. Front Cardiovasc Med., v. 7, 604826, 2021. doi: 10.3389/fcvm.2020.604826. eCollection 2020.
2297-055X
url https://www.arca.fiocruz.br/handle/icict/51176
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media S.A
publisher.none.fl_str_mv Frontiers Media S.A
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51176/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51176/2/Decreased%20Cytokine%20Plasma%20Levels%20and%20Changes%20.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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