Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/51176 |
Resumo: | Post Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil. |
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Silva, Vicente RezendeNeves, Eula Graciele AmorinPassos, Lívia Silva AraújoMelo, Flávia Cristina deCarvalho, Andrea Teixeira deNassif, Maria Cecília LandimJunqueira, Lucas LodiAikawa, ElenaDutra, Walderez OrnelasNunes, Maria Carmo Pereira2022-02-14T15:35:47Z2022-02-14T15:35:47Z2021SILVA, Vicente Rezende et al. Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis. Front Cardiovasc Med., v. 7, 604826, 2021. doi: 10.3389/fcvm.2020.604826. eCollection 2020.2297-055Xhttps://www.arca.fiocruz.br/handle/icict/51176engFrontiers Media S.ADecreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePost Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/ Department of Cardiovascular Medicine. The Center for Excellence in Vascular Biology. Brigham and Women's Hospital. Harvard Medical School. Boston, MA, United States.Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Cardiologia e Cirurgia Cardiovascular. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Cardiologia e Cirurgia Cardiovascular. Belo Horizonte, MG, Brazil.Department of Cardiovascular Medicine. The Center for Excellence in Vascular Biology. Brigham and Women's Hospital. Harvard Medical School. Boston, MA, United States.Post Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil./Laboratory of Cell-Cell Interactions. Department of Morphology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brazil.Post Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Cardiologia e Cirurgia Cardiovascular. Belo Horizonte, MG, Brazil.Mitral stenosis (MS) is a consequence of rheumatic heart disease that leads to heart failure requiring mechanical intervention. Percutaneous mitral commissurotomy (PMC) is the treatment of choice for the intervention, and currently there are no soluble markers associated with hemodynamic improvement after PMC. This study aims to determine the changes in cytokine/chemokine plasma levels, as well as T cell activation after PMC, and to investigate their association with immediate hemodynamic improvement and clinical outcomes. Plasma samples from eighteen patients with well-defined MS who underwent PMC and 12 healthy controls were analyzed using BioPlex immunoassay. We observed that 16 out of the 27 (60%) molecules assessed were altered in patients\' plasma pre-PMC as compared to control group. Of those, IL-1 beta, IL-12, IL-6, IL-4, PDGF, and CCL11 showed significant decrease after PMC. Stratifying the patients according to adverse outcome after a 28-month median follow up, we detected a significant reduction of IL-1 beta, IL-12, IL-6, IL-4, IFN-gamma, CXCL-10, VEGF, FGF and PDGF post-PMC in patients without events, but not in those who presented adverse events during the follow-up. Patients with adverse outcomes had lower IL-10 pre-PMC, as compared to the ones without adverse events. In addition, the frequency of CD8+ activated memory cells was increased after PMC, while the frequency of CD4+ activated memory cells did not change. Our results show an association between the decrease of specific cytokines and changes in T cell activation with hemodynamic improvement post-PMC, as well as with long-term outcomes, suggesting their possible use as soluble markers for hemodynamic recovery after MS intervention.T cellscytokinesmitral stenosispercutaneous mitral commissurotomyrheumatic heart diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51176/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALDecreased Cytokine Plasma Levels and Changes .pdfDecreased Cytokine Plasma Levels and Changes .pdfapplication/pdf1361671https://www.arca.fiocruz.br/bitstream/icict/51176/2/Decreased%20Cytokine%20Plasma%20Levels%20and%20Changes%20.pdf3bbcdb29763087d93a9535e5b1cffec2MD52icict/511762022-02-14 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dc.title.pt_BR.fl_str_mv |
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis |
title |
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis |
spellingShingle |
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis Silva, Vicente Rezende T cells cytokines mitral stenosis percutaneous mitral commissurotomy rheumatic heart disease |
title_short |
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis |
title_full |
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis |
title_fullStr |
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis |
title_full_unstemmed |
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis |
title_sort |
Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis |
author |
Silva, Vicente Rezende |
author_facet |
Silva, Vicente Rezende Neves, Eula Graciele Amorin Passos, Lívia Silva Araújo Melo, Flávia Cristina de Carvalho, Andrea Teixeira de Nassif, Maria Cecília Landim Junqueira, Lucas Lodi Aikawa, Elena Dutra, Walderez Ornelas Nunes, Maria Carmo Pereira |
author_role |
author |
author2 |
Neves, Eula Graciele Amorin Passos, Lívia Silva Araújo Melo, Flávia Cristina de Carvalho, Andrea Teixeira de Nassif, Maria Cecília Landim Junqueira, Lucas Lodi Aikawa, Elena Dutra, Walderez Ornelas Nunes, Maria Carmo Pereira |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Vicente Rezende Neves, Eula Graciele Amorin Passos, Lívia Silva Araújo Melo, Flávia Cristina de Carvalho, Andrea Teixeira de Nassif, Maria Cecília Landim Junqueira, Lucas Lodi Aikawa, Elena Dutra, Walderez Ornelas Nunes, Maria Carmo Pereira |
dc.subject.en.pt_BR.fl_str_mv |
T cells cytokines mitral stenosis percutaneous mitral commissurotomy rheumatic heart disease |
topic |
T cells cytokines mitral stenosis percutaneous mitral commissurotomy rheumatic heart disease |
description |
Post Graduate Program in Infectious Diseases and Tropical Medicine. School of Medicine. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-02-14T15:35:47Z |
dc.date.available.fl_str_mv |
2022-02-14T15:35:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Vicente Rezende et al. Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis. Front Cardiovasc Med., v. 7, 604826, 2021. doi: 10.3389/fcvm.2020.604826. eCollection 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/51176 |
dc.identifier.issn.pt_BR.fl_str_mv |
2297-055X |
identifier_str_mv |
SILVA, Vicente Rezende et al. Decreased Cytokine Plasma Levels and Changes in T-Cell Activation Are Associated With Hemodynamic Improvement and Clinical Outcomes After Percutaneous Mitral Commissurotomy in Patients With Rheumatic Mitral Stenosis. Front Cardiovasc Med., v. 7, 604826, 2021. doi: 10.3389/fcvm.2020.604826. eCollection 2020. 2297-055X |
url |
https://www.arca.fiocruz.br/handle/icict/51176 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Frontiers Media S.A |
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Frontiers Media S.A |
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Repositório Institucional da FIOCRUZ (ARCA) |
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