Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18766 |
Resumo: | Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. |
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Neves, Elizabeth de SouzaCuri, André Luis LandAlbuquerque, Maira Cavalcanti deSilva, Cassius Schnel PalhanoSilva, Laura Berriel daBueno, Wendy FernandesAmendoeira, Maria Regina dos ReisAlmeida, Maria da Glória Bonecini deFernandes, Octavio2017-05-04T17:57:02Z2017-05-04T17:57:02Z2012NEVES, Elizabeth de Souza et al. Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis. Revista da Sociedade Brasileira de Medicina Tropical, v. 45, n. 6, p. 757-760, Nov./Dec. 2012.0037-8682https://www.arca.fiocruz.br/handle/icict/1876610.1590/S0037-868220120006000201678-9849engSociedade Brasileira de Medicina TropicalToxoplasmoseRetinocoroiditeInterferon gammaToxoplasmosisInterferon gammaRetinochoroiditisGenetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Vice Direção de Pós-Graduação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratório de Imunologia e Imunogenética. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia Molecular de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. Methods: A case-control study was conducted among 30 patients and 90 controls. Results: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. Conclusions: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18766/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmaira_albuquerque_etal_IOC_2012.pdfmaira_albuquerque_etal_IOC_2012.pdfapplication/pdf645020https://www.arca.fiocruz.br/bitstream/icict/18766/2/maira_albuquerque_etal_IOC_2012.pdf423d20d0d2dc1524ad11aaf678d1720bMD52TEXTmaira_albuquerque_etal_IOC_2012.pdf.txtmaira_albuquerque_etal_IOC_2012.pdf.txtExtracted texttext/plain18548https://www.arca.fiocruz.br/bitstream/icict/18766/3/maira_albuquerque_etal_IOC_2012.pdf.txtd556d5f5279431c2974e56a2306d7236MD53icict/187662023-09-14 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| dc.title.pt_BR.fl_str_mv |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
| title |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
| spellingShingle |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis Neves, Elizabeth de Souza Toxoplasmose Retinocoroidite Interferon gamma Toxoplasmosis Interferon gamma Retinochoroiditis |
| title_short |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
| title_full |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
| title_fullStr |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
| title_full_unstemmed |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
| title_sort |
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis |
| author |
Neves, Elizabeth de Souza |
| author_facet |
Neves, Elizabeth de Souza Curi, André Luis Land Albuquerque, Maira Cavalcanti de Silva, Cassius Schnel Palhano Silva, Laura Berriel da Bueno, Wendy Fernandes Amendoeira, Maria Regina dos Reis Almeida, Maria da Glória Bonecini de Fernandes, Octavio |
| author_role |
author |
| author2 |
Curi, André Luis Land Albuquerque, Maira Cavalcanti de Silva, Cassius Schnel Palhano Silva, Laura Berriel da Bueno, Wendy Fernandes Amendoeira, Maria Regina dos Reis Almeida, Maria da Glória Bonecini de Fernandes, Octavio |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Neves, Elizabeth de Souza Curi, André Luis Land Albuquerque, Maira Cavalcanti de Silva, Cassius Schnel Palhano Silva, Laura Berriel da Bueno, Wendy Fernandes Amendoeira, Maria Regina dos Reis Almeida, Maria da Glória Bonecini de Fernandes, Octavio |
| dc.subject.other.pt_BR.fl_str_mv |
Toxoplasmose Retinocoroidite Interferon gamma |
| topic |
Toxoplasmose Retinocoroidite Interferon gamma Toxoplasmosis Interferon gamma Retinochoroiditis |
| dc.subject.en.pt_BR.fl_str_mv |
Toxoplasmosis Interferon gamma Retinochoroiditis |
| description |
Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. |
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2012 |
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2012 |
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2017-05-04T17:57:02Z |
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2017-05-04T17:57:02Z |
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NEVES, Elizabeth de Souza et al. Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis. Revista da Sociedade Brasileira de Medicina Tropical, v. 45, n. 6, p. 757-760, Nov./Dec. 2012. |
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https://www.arca.fiocruz.br/handle/icict/18766 |
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0037-8682 |
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10.1590/S0037-86822012000600020 |
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1678-9849 |
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NEVES, Elizabeth de Souza et al. Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis. Revista da Sociedade Brasileira de Medicina Tropical, v. 45, n. 6, p. 757-760, Nov./Dec. 2012. 0037-8682 10.1590/S0037-86822012000600020 1678-9849 |
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