Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice

Detalhes bibliográficos
Autor(a) principal: Demarque, Kelly C.
Data de Publicação: 2020
Outros Autores: Tavares, Ana C. Dutra, Freitas, André L. Nunes, Araújo, Ulisses C., Manhães, Alex C., Villaça, Yael Abreu, Filgueiras, Cláudio C., Carvalho, Anderson Ribeiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43091
Resumo: Acesso aberto em 31/08/2020 - https://onlinelibrary.wiley.com/doi/abs/10.1002/jdn.10017
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spelling Demarque, Kelly C.Tavares, Ana C. DutraFreitas, André L. NunesAraújo, Ulisses C.Manhães, Alex C.Villaça, Yael AbreuFilgueiras, Cláudio C.Carvalho, Anderson Ribeiro2020-08-31T19:17:52Z2020-08-31T19:17:52Z2020DEMARQUE, Kelly C. et al. Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice. International Journal of Developmental Neuroscience, v. 80, p. 197-207, 2020.0736-5748https://www.arca.fiocruz.br/handle/icict/4309110.1002/jdn.100171873-474XAcesso aberto em 31/08/2020 - https://onlinelibrary.wiley.com/doi/abs/10.1002/jdn.10017Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcantara Gomes. Departamento de Ciências Fisiológicas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcantara Gomes. Departamento de Ciências Fisiológicas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcantara Gomes. Departamento de Ciências Fisiológicas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcantara Gomes. Departamento de Ciências Fisiológicas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcantara Gomes. Departamento de Ciências Fisiológicas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcantara Gomes. Departamento de Ciências Fisiológicas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Formação de Professores. Departamento de Ciências. São Gonçalo, RJ, Brasil.The brain is particularly vulnerable to ethanol effects during its growth spurt. Outcomes of early ethanol exposure such as hyperactivity have been extensively investigated; however, persons with fetal alcohol spectrum disorder frequently have social impairments and are heavy drinkers. Despite that, scant information is available regarding the neurobiological basis of these latter behavioral issues. Here, Swiss mice exposed to ethanol (Etoh, 5 g/kg i.p., alternate days) or saline during the brain growth spurt [postnatal day (PN) 2 to 8] were used to assess social behavior after an ethanol challenging during adolescence. At PN39, animals were administered with a single ethanol dose (1 g/Kg) or water by gavage and were then evaluated in the three-chamber sociability test. We also evaluated corticosterone serum levels and the frontal cerebral cortex serotoninergic system. Etoh males showed reductions in sociability. Ethanol challenging reverted these alterations in social behavior, reduced corticosterone levels, and increased the 5-HT2 receptor binding of male Etoh mice. No alterations were observed in 5-HT and 5-HIAA contents. These data support the idea that ethanol exposure during the brain growth spurt impacts social abilities during adolescence, alters ethanol reexposure effects, and suggests that stress response and serotoninergic system play roles in this phenomenon.engOxfordCorticosteronaDesenvolvimentoSistema serotoninérgicoComportamento socialCorticosteroneDevelopmentSerotoninergic systemSocial behaviorEthanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice
title Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice
spellingShingle Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice
Demarque, Kelly C.
Corticosterona
Desenvolvimento
Sistema serotoninérgico
Comportamento social
Corticosterone
Development
Serotoninergic system
Social behavior
title_short Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice
title_full Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice
title_fullStr Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice
title_full_unstemmed Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice
title_sort Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice
author Demarque, Kelly C.
author_facet Demarque, Kelly C.
Tavares, Ana C. Dutra
Freitas, André L. Nunes
Araújo, Ulisses C.
Manhães, Alex C.
Villaça, Yael Abreu
Filgueiras, Cláudio C.
Carvalho, Anderson Ribeiro
author_role author
author2 Tavares, Ana C. Dutra
Freitas, André L. Nunes
Araújo, Ulisses C.
Manhães, Alex C.
Villaça, Yael Abreu
Filgueiras, Cláudio C.
Carvalho, Anderson Ribeiro
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Demarque, Kelly C.
Tavares, Ana C. Dutra
Freitas, André L. Nunes
Araújo, Ulisses C.
Manhães, Alex C.
Villaça, Yael Abreu
Filgueiras, Cláudio C.
Carvalho, Anderson Ribeiro
dc.subject.other.pt_BR.fl_str_mv Corticosterona
Desenvolvimento
Sistema serotoninérgico
Comportamento social
topic Corticosterona
Desenvolvimento
Sistema serotoninérgico
Comportamento social
Corticosterone
Development
Serotoninergic system
Social behavior
dc.subject.en.pt_BR.fl_str_mv Corticosterone
Development
Serotoninergic system
Social behavior
description Acesso aberto em 31/08/2020 - https://onlinelibrary.wiley.com/doi/abs/10.1002/jdn.10017
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-08-31T19:17:52Z
dc.date.available.fl_str_mv 2020-08-31T19:17:52Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DEMARQUE, Kelly C. et al. Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice. International Journal of Developmental Neuroscience, v. 80, p. 197-207, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43091
dc.identifier.issn.pt_BR.fl_str_mv 0736-5748
dc.identifier.doi.none.fl_str_mv 10.1002/jdn.10017
dc.identifier.eissn.none.fl_str_mv 1873-474X
identifier_str_mv DEMARQUE, Kelly C. et al. Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice. International Journal of Developmental Neuroscience, v. 80, p. 197-207, 2020.
0736-5748
10.1002/jdn.10017
1873-474X
url https://www.arca.fiocruz.br/handle/icict/43091
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford
publisher.none.fl_str_mv Oxford
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/43091/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/43091/2/KellyDemarque_etal_IOC_2020.pdf
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