Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment

Detalhes bibliográficos
Autor(a) principal: Bongertz, Vera
Data de Publicação: 2007
Outros Autores: Ouverney, E. Priscilla, Fernandez, Saada Chequer, Grinsztejn, Beatriz, Veloso, Valdiléa G., Couto-Fernandez, José C., Pilotto, José H., Morgado, Mariza G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31130
Resumo: Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Bongertz, VeraOuverney, E. PriscillaFernandez, Saada ChequerGrinsztejn, BeatrizVeloso, Valdiléa G.Couto-Fernandez, José C.Pilotto, José H.Morgado, Mariza G.2019-01-17T22:17:16Z2019-01-17T22:17:16Z2007BONGERTZ, Vera et al. Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 7, p. 817-825, Nov. 2007.0074-0276https://www.arca.fiocruz.br/handle/icict/3113010.1590/S0074-027620070050001191678-8060engInstituto Oswaldo CruzAnti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Highly active antiretroviral treatment (HAART) of human immunodeficiency type 1 (HIV-1) infection is very effective in controlling infection, but elimination of viral infection has not been achieved as yet, and upon treatment interruption an immediate rebound of viremia is observed. A combination of HAART with an immune stimulation might allow treatment interruption without this rebounding viremia, as the very low viremias observed with successful HAART may be insufficient to permit maintenance of a specific anti-HIV-1 immune response. The objective of this study was to compare the humoral immune response of individuals undergoing successful HAART (NF=no failure) with that of individuals with evidence of failure of therapy (FT) and to verify if the viremia peaks observed in individuals with therapy failure would act as a specific stimulus for the humoral anti-HIV-1 immune response. Antibodies binding to gp120 V3 genotype consensus peptides were more frequently observed for FT, mainly against peptides corresponding to sequences of genotypes prevalent in the Rio de Janeiro city area, B and F. HIV-1 neutralization of HIV-1 IIIB and of four primary isolates from Rio de Janeiro was less frequently observed for plasma from the NF than the FT group, but this difference was more expressive when plasma from individuals with detectable viremia were compared to that of individuals with undetectable viral loads in the year before sample collection. Although statistically significant differences were observed only in some specific comparisons, the study indicates that presence of detectable viremia may contribute to the maintenance of a specific anti-HIV-1 humoral immune response.AntibodiesSeroreactivityNeutralizationAntiretroviral treatmentTreatment failureinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/31130/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALAnti-human immunodeficiency_Beatriz_Grinsztejn_INI_Lapclin-AIDS_2007.pdfAnti-human immunodeficiency_Beatriz_Grinsztejn_INI_Lapclin-AIDS_2007.pdfapplication/pdf199816https://www.arca.fiocruz.br/bitstream/icict/31130/2/Anti-human%20immunodeficiency_Beatriz_Grinsztejn_INI_Lapclin-AIDS_2007.pdf0aebf30c8963e60747c7469c9aafe153MD52TEXTAnti-human 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dc.title.pt_BR.fl_str_mv Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment
title Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment
spellingShingle Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment
Bongertz, Vera
Antibodies
Seroreactivity
Neutralization
Antiretroviral treatment
Treatment failure
title_short Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment
title_full Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment
title_fullStr Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment
title_full_unstemmed Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment
title_sort Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment
author Bongertz, Vera
author_facet Bongertz, Vera
Ouverney, E. Priscilla
Fernandez, Saada Chequer
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Couto-Fernandez, José C.
Pilotto, José H.
Morgado, Mariza G.
author_role author
author2 Ouverney, E. Priscilla
Fernandez, Saada Chequer
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Couto-Fernandez, José C.
Pilotto, José H.
Morgado, Mariza G.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bongertz, Vera
Ouverney, E. Priscilla
Fernandez, Saada Chequer
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Couto-Fernandez, José C.
Pilotto, José H.
Morgado, Mariza G.
dc.subject.en.pt_BR.fl_str_mv Antibodies
Seroreactivity
Neutralization
Antiretroviral treatment
Treatment failure
topic Antibodies
Seroreactivity
Neutralization
Antiretroviral treatment
Treatment failure
description Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2019-01-17T22:17:16Z
dc.date.available.fl_str_mv 2019-01-17T22:17:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BONGERTZ, Vera et al. Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 7, p. 817-825, Nov. 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31130
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762007005000119
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv BONGERTZ, Vera et al. Anti-human immunodeficiency virus type 1 humoral immune response and highly active antiretroviral treatment. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 7, p. 817-825, Nov. 2007.
0074-0276
10.1590/S0074-02762007005000119
1678-8060
url https://www.arca.fiocruz.br/handle/icict/31130
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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