Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15542 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil. |
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Silva, Michele CostaBarros, Lucas de AndradeGarcia, Juberlan SilvaNeves, Renata HeislerSilva, Rosângela RodriguesSilva, José Roberto MachadoMaldonado Júnior, Arnaldo2016-08-30T16:22:47Z2016-08-30T16:22:47Z2012SILVA, Michele Costa; et al. Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice. Experimental Parasitology, v.130, n.4, p.394-399, Apr. 2012.0014-4894https://www.arca.fiocruz.br/handle/icict/1554210.1016/j.exppara.2012.02.0021090-2449engElsevierSchistosoma mansoniPraziquantelHospedeiros não humanosSuscetibilidadeEstudo parasitológicoPraziquantelSusceptibilitySchistosoma mansoniNon-human hostNectomys squamipesParasitological studySusceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil.The therapeutic effects of praziquantel (PZQ) against a Schistosoma mansoni isolate derived from Nectomys squamipes (isolate R) and a susceptible isolate (BH) were analyzed in Swiss mice by fecal egg counting, adult worm reduction and oogram pattern. Infected mice were orally administrated with 62.5mg/kg (group 1), 125mg/kg (group 2), 250mg/kg (group 3) and 500mg/kg (group 4), each dose divided over 3 days (49, 50 and 51 days after infection). The data were analyzed using one-way analysis of variance (ANOVA). In regard to isolate R, no fecal eggs were observed with 250 mg/Kg and 500 mg/kg (p<0.05), whereas BH excretion reached zero with all doses. Mean worm burden reduction was significantly (p<0.05) higher at the two highest concentrations, regardless of isolate. At 62.5mg/kg, the percentage of immature eggs varied from 17% (isolate R) to 38% (isolate BH). At 125 mg/kg, the percentage of immature eggs varied from 20% (isolate R) to 16% (isolate BH). At 250 mg/kg, immature eggs dropped significantly to 1% (isolate R) and 4% (isolate BH). At 500 mg/kg, no immature eggs were found in isolate R, whereas in BH was 8%. No dosage significantly (p>0.05) affected the percentage of mature eggs, regardless of isolate. There was a large increase (p<0.001) in the percentages of dead eggs in all treated groups of 62% and 64% in groups 3 and 4, respectively (isolate R). The percentage of dead eggs rose from 34% (group 1) to 58% (group 3) in isolate BH. Although group 4 showed lowest increase in the percentage of dead eggs (46%), it was higher (p<0.001) compared to the 8% in the control. Our findings indicate that the wild isolate from N. squamipes is susceptible to PZQ.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15542/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmichele_silva_etal_IOC_2012.pdfmichele_silva_etal_IOC_2012.pdfapplication/pdf368762https://www.arca.fiocruz.br/bitstream/icict/15542/2/michele_silva_etal_IOC_2012.pdf8e2d32968d7f85649638d5405c3b3a4eMD52TEXTmichele_silva_etal_IOC_2012.pdf.txtmichele_silva_etal_IOC_2012.pdf.txtExtracted texttext/plain36184https://www.arca.fiocruz.br/bitstream/icict/15542/3/michele_silva_etal_IOC_2012.pdf.txt6a19acc759634794db41f05653a447afMD53icict/155422018-04-02 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| dc.title.pt_BR.fl_str_mv |
Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice |
| title |
Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice |
| spellingShingle |
Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice Silva, Michele Costa Schistosoma mansoni Praziquantel Hospedeiros não humanos Suscetibilidade Estudo parasitológico Praziquantel Susceptibility Schistosoma mansoni Non-human host Nectomys squamipes Parasitological study |
| title_short |
Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice |
| title_full |
Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice |
| title_fullStr |
Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice |
| title_full_unstemmed |
Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice |
| title_sort |
Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice |
| author |
Silva, Michele Costa |
| author_facet |
Silva, Michele Costa Barros, Lucas de Andrade Garcia, Juberlan Silva Neves, Renata Heisler Silva, Rosângela Rodrigues Silva, José Roberto Machado Maldonado Júnior, Arnaldo |
| author_role |
author |
| author2 |
Barros, Lucas de Andrade Garcia, Juberlan Silva Neves, Renata Heisler Silva, Rosângela Rodrigues Silva, José Roberto Machado Maldonado Júnior, Arnaldo |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Michele Costa Barros, Lucas de Andrade Garcia, Juberlan Silva Neves, Renata Heisler Silva, Rosângela Rodrigues Silva, José Roberto Machado Maldonado Júnior, Arnaldo |
| dc.subject.other.pt_BR.fl_str_mv |
Schistosoma mansoni Praziquantel Hospedeiros não humanos Suscetibilidade Estudo parasitológico |
| topic |
Schistosoma mansoni Praziquantel Hospedeiros não humanos Suscetibilidade Estudo parasitológico Praziquantel Susceptibility Schistosoma mansoni Non-human host Nectomys squamipes Parasitological study |
| dc.subject.en.pt_BR.fl_str_mv |
Praziquantel Susceptibility Schistosoma mansoni Non-human host Nectomys squamipes Parasitological study |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil. |
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2012 |
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2012 |
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2016-08-30T16:22:47Z |
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2016-08-30T16:22:47Z |
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SILVA, Michele Costa; et al. Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice. Experimental Parasitology, v.130, n.4, p.394-399, Apr. 2012. |
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0014-4894 |
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10.1016/j.exppara.2012.02.002 |
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1090-2449 |
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SILVA, Michele Costa; et al. Susceptibility of a Brazilian wild rodent isolate of Schistosoma mansoni to praziquantel in mice. Experimental Parasitology, v.130, n.4, p.394-399, Apr. 2012. 0014-4894 10.1016/j.exppara.2012.02.002 1090-2449 |
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