Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV

Detalhes bibliográficos
Autor(a) principal: Jeovanio-Silva, André L.
Data de Publicação: 2012
Outros Autores: Monteiro, Thaís P., El-Jaick, Kênia B., Brasil, Pedro E.A.A. do, Rolla, Valéria C., Castro, Liane
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36622
Resumo: 2020-04-22
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spelling Jeovanio-Silva, André L.Monteiro, Thaís P.El-Jaick, Kênia B.Brasil, Pedro E.A.A. doRolla, Valéria C.Castro, Liane2019-10-22T12:35:43Z2019-10-22T12:35:43Z2012JEOVANIO-SILVA, André L. et al. Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV. Molecular Medicine Reports, v. 5, p. 153-161, 2012.1791-2997https://www.arca.fiocruz.br/handle/icict/3662210.3892/mmr.2011.6021791-3004engSpandidos PublicationsUnique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIVinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-04-22Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Biomarcadores e Hepatotoxicidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Biomarcadores e Hepatotoxicidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Biomarcadores e Hepatotoxicidade. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Biomarcadores e Hepatotoxicidade. Rio de Janeiro, RJ, Brasil.CYP3A4 is involved in tuberculosis (TB) and human immunodeficiency virus (HIV) drug metabolism. Transcriptional activation by rifampicin involves the CYP3A4 gene 5'-upstream region. Consequently, variation may interfere with transcription and enzymatic activity and even drug response. However, genetic polymorphisms and distribution of CYP3A4 allelic frequencies in individuals from Rio de Janeiro remain unknown. The aim of this study was to conduct research into sequencing the CYP3A4 5'-upstream region in Brazilian patients with and without HIV. This follow-up study involved 106 individuals undergoing treatment for TB and/or HIV. The CYP3A4 5'-upstream region was analyzed using PCR, sequencing and clinical data. Male patients revealed a higher HIV frequency (p=0.021). The TB forms observed were pulmonary (48.1%), extrapulmonary (22.64%) and disseminated (27.36%). Lymph node form was the most frequent (70.83%) extrapulmonary form of TB. The only single nucleotide polymorphism detected in the population was c.-392A>G. Genotypes observed were CYP3A4*1A/CYP3A4*1A (45.3%), CYP3A4*1A/CYP3A4*1B (40.6%) and CYP3A4*1B/CYP3A4*1B (14.2%), revealing a different distribution with extrapulmonary TB cases (17.6% CYP3A4*1A/CYP3A4*1B and 23.5% CYP3A4*1B/CYP3A4*1B). The CYP3A4*1A allele was found to be associated with tobacco use. The CYP3A4*1B mutant allele occurred in 34% of patients. This study revealed that the CYP3A4 5'-upstream regulatory region was highly conserved with the exception of the -392 position. Genotype association with tobacco suggests that CYP3A4 may participate in tobacco metabolism. Genotype distribution inversion in extrapulmonary TB cases suggests that CYP3A4 may be involved in TB prognosis.BrazilCYP3A4 promoter regionCYP3A4 upstream region sequence analysisCYP3A4*1BGenetic polymorphismTuberculosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36622/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Jeovanio-Silva_André_etal_INI_2012.pdfve_Jeovanio-Silva_André_etal_INI_2012.pdfapplication/pdf363867https://www.arca.fiocruz.br/bitstream/icict/36622/2/ve_Jeovanio-Silva_Andr%c3%a9_etal_INI_2012.pdf135d3ac6df1ae0087166ccc6ba81a48eMD52TEXTve_Jeovanio-Silva_André_etal_INI_2012.pdf.txtve_Jeovanio-Silva_André_etal_INI_2012.pdf.txtExtracted texttext/plain50787https://www.arca.fiocruz.br/bitstream/icict/36622/3/ve_Jeovanio-Silva_Andr%c3%a9_etal_INI_2012.pdf.txta7ee8f6718a1b3574ba6fc1d550f83acMD53icict/366222021-03-24 16:32:30.964oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV
title Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV
spellingShingle Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV
Jeovanio-Silva, André L.
Brazil
CYP3A4 promoter region
CYP3A4 upstream region sequence analysis
CYP3A4*1B
Genetic polymorphism
Tuberculosis
title_short Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV
title_full Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV
title_fullStr Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV
title_full_unstemmed Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV
title_sort Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV
author Jeovanio-Silva, André L.
author_facet Jeovanio-Silva, André L.
Monteiro, Thaís P.
El-Jaick, Kênia B.
Brasil, Pedro E.A.A. do
Rolla, Valéria C.
Castro, Liane
author_role author
author2 Monteiro, Thaís P.
El-Jaick, Kênia B.
Brasil, Pedro E.A.A. do
Rolla, Valéria C.
Castro, Liane
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Jeovanio-Silva, André L.
Monteiro, Thaís P.
El-Jaick, Kênia B.
Brasil, Pedro E.A.A. do
Rolla, Valéria C.
Castro, Liane
dc.subject.en.pt_BR.fl_str_mv Brazil
CYP3A4 promoter region
CYP3A4 upstream region sequence analysis
CYP3A4*1B
Genetic polymorphism
Tuberculosis
topic Brazil
CYP3A4 promoter region
CYP3A4 upstream region sequence analysis
CYP3A4*1B
Genetic polymorphism
Tuberculosis
description 2020-04-22
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-10-22T12:35:43Z
dc.date.available.fl_str_mv 2019-10-22T12:35:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv JEOVANIO-SILVA, André L. et al. Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV. Molecular Medicine Reports, v. 5, p. 153-161, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36622
dc.identifier.issn.pt_BR.fl_str_mv 1791-2997
dc.identifier.doi.none.fl_str_mv 10.3892/mmr.2011.602
dc.identifier.eissn.none.fl_str_mv 1791-3004
identifier_str_mv JEOVANIO-SILVA, André L. et al. Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV. Molecular Medicine Reports, v. 5, p. 153-161, 2012.
1791-2997
10.3892/mmr.2011.602
1791-3004
url https://www.arca.fiocruz.br/handle/icict/36622
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Spandidos Publications
publisher.none.fl_str_mv Spandidos Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/36622/1/license.txt
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