Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives

Detalhes bibliográficos
Autor(a) principal: Souza, Tainá Santos
Data de Publicação: 2022
Outros Autores: Moreira, Diogo Rodrigo Magalhães, Marcelino, Henrique Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55050
Resumo: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES).
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spelling Souza, Tainá SantosMoreira, Diogo Rodrigo MagalhãesMarcelino, Henrique Rodrigues2022-10-07T14:57:36Z2022-10-07T14:57:36Z2022SOUZA, Tainá Santos et al. Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives. Pharmaceutics, v. 14, p. 1-19, 2022.1999-4923https://www.arca.fiocruz.br/handle/icict/5505010.3390/ pharmaceutics14071383Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES).Universidade Federal da Bahia. Faculdade de Farmácia. Programa de Pós-Graduação em Farmácia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Programa de Pós-Graduação em Farmácia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Medicamentos. Salvador, BA, Brasil.Abstract: Decoquinate (DQ) is an antimicrobial agent commonly used as a feed additive for birds for human consumption. Its use as an additive is well established, but DQ has the potential for therapy as an antimicrobial drug for veterinary treatment and its optimized derivatives and/or formulations, mainly nanoformulations, have antimicrobial activity against pathogens that infect humans. However, DQ has a high partition coefficient and low solubility in aqueous fluids, and these biopharmaceutical properties have limited its use in humans. In this review, we highlight the antimicrobial activity and pharmacokinetic properties of DQ and highlight the solutions currently under investigation to overcome these drawbacks. A literature search was conducted focusing on the use of decoquinate against various infectious diseases in humans and animals. The search was conducted in several databases, including scientific and patent databases. Pharmaceutical nanotechnology and medicinal chemistry are the tools of choice to achieve human applications, and most of these applications have been able to improve the biopharmaceutical properties and pharmacokinetic profile of DQ. Based on the results presented here, DQ prototypes could be tested in clinical trials for human application in the coming years.engMDPIDecoquinateChemistry, PharmaceuticalDecoquinatoAntimicrobianoPropriedades físico-químicasQuímica MedicinalNanomedicamentosDecoquinateAntimicrobialPhysicochemical propertiesMedicinal chemistryNanomedicinesDecoquinatoAnti-InfecciososQuímica farmacêuticaChemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectivesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55050/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSouza, Tainá Santos - Chemical and pharmacological properties of decoquinate.pdfSouza, Tainá Santos - Chemical and pharmacological properties of decoquinate.pdfapplication/pdf2679480https://www.arca.fiocruz.br/bitstream/icict/55050/2/Souza%2c%20Tain%c3%a1%20Santos%20-%20Chemical%20and%20pharmacological%20properties%20of%20decoquinate.pdfd3bfae38ff755057f89f235380b3c6deMD52icict/550502023-03-15 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dc.title.en_US.fl_str_mv Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives
title Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives
spellingShingle Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives
Souza, Tainá Santos
Decoquinate
Chemistry, Pharmaceutical
Decoquinato
Antimicrobiano
Propriedades físico-químicas
Química Medicinal
Nanomedicamentos
Decoquinate
Antimicrobial
Physicochemical properties
Medicinal chemistry
Nanomedicines
Decoquinato
Anti-Infecciosos
Química farmacêutica
title_short Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives
title_full Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives
title_fullStr Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives
title_full_unstemmed Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives
title_sort Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives
author Souza, Tainá Santos
author_facet Souza, Tainá Santos
Moreira, Diogo Rodrigo Magalhães
Marcelino, Henrique Rodrigues
author_role author
author2 Moreira, Diogo Rodrigo Magalhães
Marcelino, Henrique Rodrigues
author2_role author
author
dc.contributor.author.fl_str_mv Souza, Tainá Santos
Moreira, Diogo Rodrigo Magalhães
Marcelino, Henrique Rodrigues
dc.subject.mesh.en_US.fl_str_mv Decoquinate
Chemistry, Pharmaceutical
topic Decoquinate
Chemistry, Pharmaceutical
Decoquinato
Antimicrobiano
Propriedades físico-químicas
Química Medicinal
Nanomedicamentos
Decoquinate
Antimicrobial
Physicochemical properties
Medicinal chemistry
Nanomedicines
Decoquinato
Anti-Infecciosos
Química farmacêutica
dc.subject.other.en_US.fl_str_mv Decoquinato
Antimicrobiano
Propriedades físico-químicas
Química Medicinal
Nanomedicamentos
dc.subject.en.en_US.fl_str_mv Decoquinate
Antimicrobial
Physicochemical properties
Medicinal chemistry
Nanomedicines
dc.subject.decs.en_US.fl_str_mv Decoquinato
Anti-Infecciosos
Química farmacêutica
description Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-07T14:57:36Z
dc.date.available.fl_str_mv 2022-10-07T14:57:36Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA, Tainá Santos et al. Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives. Pharmaceutics, v. 14, p. 1-19, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55050
dc.identifier.issn.en_US.fl_str_mv 1999-4923
dc.identifier.doi.none.fl_str_mv 10.3390/ pharmaceutics14071383
identifier_str_mv SOUZA, Tainá Santos et al. Chemical and pharmacological properties of decoquinate: a review of its pharmaceutical potential and future perspectives. Pharmaceutics, v. 14, p. 1-19, 2022.
1999-4923
10.3390/ pharmaceutics14071383
url https://www.arca.fiocruz.br/handle/icict/55050
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55050/1/license.txt
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