Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity

Detalhes bibliográficos
Autor(a) principal: Cerávolo, Isabela Penna
Data de Publicação: 2018
Outros Autores: Zani, Carlos Leomar, Figueiredo, Flávio Júnior Barbosa, Kohlhoff, Markus, Santana, Antônio Euzébio Goulart, Krettli, Antoniana Ursine
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33854
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malaria Humana e Experimental. Belo Horizonte, MG, Brasil.
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spelling Cerávolo, Isabela PennaZani, Carlos LeomarFigueiredo, Flávio Júnior BarbosaKohlhoff, MarkusSantana, Antônio Euzébio GoulartKrettli, Antoniana Ursine2019-07-04T17:30:10Z2019-07-04T17:30:10Z2018CERÁVOLO, Isabela Pena et al. Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity. Malaria Journal, v. 17, n. 1, p. 1-11, 2018.1475-2875https://www.arca.fiocruz.br/handle/icict/3385410.1186/s12936-018-2568-yengBioMed CentralAnti-malaricosAspidosperma pyrifoliumEtnofarmacologiaPlantas medicinaisPlasmodium falciparumAnti-malarialAspidosperma pyrifoliumEthnopharmacologyMedicinal plantsPlasmodium falciparumAspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malaria Humana e Experimental. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Quimica de Produtos Naturais. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malaria Humana e Experimental. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Quimica de Produtos Naturais. Belo Horizonte, MG, Brasil.Universidade Federal de Alagoas. Centro de Ciências Agrárias. Maceió, AL, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malaria Humana e Experimental. Belo Horizonte, MG, Brasil.BACKGROUND: Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum. Aspidosperma pyrifolium, also a medicinal plant, is used as a natural anti-inflammatory. Its fractionated extracts were assayed in vitro for activity against malaria parasites and for cytotoxicity. METHODS: Aspidosperma pyrifolium activity was evaluated against Plasmodium falciparum using extracts in vitro. Toxicity towards human hepatoma cells, monkey kidney cells or human monocytes freshly isolated from peripheral blood was also assessed. Anti-malarial activity of selected extracts and fractions that presented in vitro activity were tested in mice with a Plasmodium berghei blood-induced infection. RESULTS: The crude stem bark extract and the alkaloid-rich and ethyl acetate fractions from stem extract showed in vitro activity. None of the crude extracts or fractions was cytotoxic to normal monkey kidney and to a human hepatoma cell lines, or human peripheral blood mononuclear cells; the MDL50 values of all the crude bark extracts and fractions were similar or better when tested on normal cells, with the exception of organic and alkaloidic-rich fractions from stem extract. Two extracts and two fractions tested in vivo caused a significant reduction of P. berghei parasitaemia in experimentally infected mice. CONCLUSION: Considering the high therapeutic index of the alkaloidic-rich fraction from stem extract of A. pyrifolium, it makes the species a candidate for further investigation aiming to produce a new anti-malarial, especially considering that the active extract has no toxicity, i.e., no mutagenic effects in the genototoxicity assays, and that it has an in vivo anti-malarial effect. In its UPLC-HRMS analysis this fraction was shown to have two major components compatible with the bisindole alkaloid Leucoridine B, and a novel compound, which is likely to be responsible for the activity against malaria parasites demonstrated in in vitro tests.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/33854/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALAspidosperma pyrifolium.pdfAspidosperma pyrifolium.pdfapplication/pdf4888177https://www.arca.fiocruz.br/bitstream/icict/33854/2/Aspidosperma%20pyrifolium.pdfe33814a3b52f11d8da7ca2b0a7f8b8bcMD52TEXTAspidosperma pyrifolium.pdf.txtAspidosperma pyrifolium.pdf.txtExtracted texttext/plain879https://www.arca.fiocruz.br/bitstream/icict/33854/3/Aspidosperma%20pyrifolium.pdf.txte8c24b2479a29e4f5179d06f19db612cMD53icict/338542019-11-11 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dc.title.pt_BR.fl_str_mv Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity
title Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity
spellingShingle Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity
Cerávolo, Isabela Penna
Anti-malaricos
Aspidosperma pyrifolium
Etnofarmacologia
Plantas medicinais
Plasmodium falciparum
Anti-malarial
Aspidosperma pyrifolium
Ethnopharmacology
Medicinal plants
Plasmodium falciparum
title_short Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity
title_full Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity
title_fullStr Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity
title_full_unstemmed Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity
title_sort Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity
author Cerávolo, Isabela Penna
author_facet Cerávolo, Isabela Penna
Zani, Carlos Leomar
Figueiredo, Flávio Júnior Barbosa
Kohlhoff, Markus
Santana, Antônio Euzébio Goulart
Krettli, Antoniana Ursine
author_role author
author2 Zani, Carlos Leomar
Figueiredo, Flávio Júnior Barbosa
Kohlhoff, Markus
Santana, Antônio Euzébio Goulart
Krettli, Antoniana Ursine
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cerávolo, Isabela Penna
Zani, Carlos Leomar
Figueiredo, Flávio Júnior Barbosa
Kohlhoff, Markus
Santana, Antônio Euzébio Goulart
Krettli, Antoniana Ursine
dc.subject.other.pt_BR.fl_str_mv Anti-malaricos
Aspidosperma pyrifolium
Etnofarmacologia
Plantas medicinais
Plasmodium falciparum
topic Anti-malaricos
Aspidosperma pyrifolium
Etnofarmacologia
Plantas medicinais
Plasmodium falciparum
Anti-malarial
Aspidosperma pyrifolium
Ethnopharmacology
Medicinal plants
Plasmodium falciparum
dc.subject.en.pt_BR.fl_str_mv Anti-malarial
Aspidosperma pyrifolium
Ethnopharmacology
Medicinal plants
Plasmodium falciparum
description Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malaria Humana e Experimental. Belo Horizonte, MG, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-07-04T17:30:10Z
dc.date.available.fl_str_mv 2019-07-04T17:30:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CERÁVOLO, Isabela Pena et al. Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity. Malaria Journal, v. 17, n. 1, p. 1-11, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33854
dc.identifier.issn.pt_BR.fl_str_mv 1475-2875
dc.identifier.doi.none.fl_str_mv 10.1186/s12936-018-2568-y
identifier_str_mv CERÁVOLO, Isabela Pena et al. Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity. Malaria Journal, v. 17, n. 1, p. 1-11, 2018.
1475-2875
10.1186/s12936-018-2568-y
url https://www.arca.fiocruz.br/handle/icict/33854
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33854/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/33854/2/Aspidosperma%20pyrifolium.pdf
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