Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014

Detalhes bibliográficos
Autor(a) principal: Ampofo, William K.
Data de Publicação: 2015
Outros Autores: Azziz-Baumgartner, Eduardo, Bashir, Uzma, Cox, Nancy J., Fasce, Rodrigo, Giovanni, Maria, Grohmann, Gary, Huang, Sue, Katz, Jackie, Mironenko, Alla, Mokhtari-Azad, Talat, Sasono, Pretty Multihartina, Rahman, Mahmudur, Sawanpanyalert, Pathom, Siqueira, Marilda Agudo Mendonça Teixeira de, Waddell, Anthony L., Waiboci, Lillian, Wood, John, Zhang, Wenqing, Ziegler, Thedi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.vaccine.2015.06.090
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14264
Resumo: Noguchi Memorial Institute for Medical Research. Accra, Ghana.
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spelling Ampofo, William K.Azziz-Baumgartner, EduardoBashir, UzmaCox, Nancy J.Fasce, RodrigoGiovanni, MariaGrohmann, GaryHuang, SueKatz, JackieMironenko, AllaMokhtari-Azad, TalatSasono, Pretty MultihartinaRahman, MahmudurSawanpanyalert, PathomSiqueira, Marilda Agudo Mendonça Teixeira deWaddell, Anthony L.Waiboci, LillianWood, JohnZhang, WenqingZiegler, Thedi2016-05-12T21:39:57Z2016-05-12T21:39:57Z2015AMPOFO, William K. et al. Strengthening the influenza vaccine virus selection and development process: Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1-3 April 2014. Vaccine, v.33, n.36, p.4368-4382, Aug. 2015.0264-410Xhttps://www.arca.fiocruz.br/handle/icict/1426410.1016/j.vaccine.2015.06.0901873-2518engopen accessStrengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNoguchi Memorial Institute for Medical Research. Accra, Ghana.Centers for Disease Control and Prevention (CDC). Atlanta, GA, USA.National Institute of Health. Islamabad, Pakistan.Centers for Disease Control and Prevention (CDC). Atlanta, GA,Public Health Institute of Chile. National Influenza Center. Chile.National Institutes of Health. Bethesda, MD, USA.Therapeutics Goods Administration. Symonston, Australia.National Influenza Center. Upper Hutt, New Zealand.Centers for Disease Control and Prevention (CDC). Atlanta, GA,Reference Influenza Laboratory. Kiev, Ukraine.National Influenza Center. Tehran, Islamic Republic of Iran.National Institute of Health Research and Development.Jakarta, Indonesia.Institute of Epidemiology, Disease Control and Research. Dhaka, Bangladesh.National Institute of Health. Bangkok, Thailand.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Freelancer. Stanley, UK.CDC Kenya. Nairobi, Kenya.Formerly National Institute for Biological Standards and Control (NIBSC). Potters Bar, UK.World Health Organization (WHO. Geneva, SwitzerlandNational Influenza Center. Helsinki, Finland.Despite long-recognized challenges and constraints associated with their updating and manufacture, influenza vaccines remain at the heart of public health preparedness and response efforts against both seasonal and potentially pandemic influenza viruses. Globally coordinated virological and epidemiological surveillance is the foundation of the influenza vaccine virus selection and development process. Although national influenza surveillance and reporting capabilities are being strengthened and expanded, sustaining and building upon recent gains has become a major challenge. Strengthening the vaccine virus selection process additionally requires the continuation of initiatives to improve the timeliness and representativeness of influenza viruses shared by countries for detailed analysis by the WHO Global Influenza Surveillance and Response System (GISRS). Efforts are also continuing at the national, regional, and global levels to better understand the dynamics of influenza transmission in both temperate and tropical regions. Improved understanding of the degree of influenza seasonality in tropical countries of the world should allow for the strengthening of national vaccination policies and use of the most appropriate available vaccines. There remain a number of limitations and difficulties associated with the use of HAI assays for the antigenic characterization and selection of influenza vaccine viruses by WHOCCs. Current approaches to improving the situation include the more-optimal use of HAI and other assays; improved understanding of the data produced by neutralization assays; and increased standardization of serological testing methods. A number of new technologies and associated tools have the potential to revolutionize influenza surveillance and response activities. These include the increasingly routine use of whole genome next-generation sequencing and other high-throughput approaches. Such approaches could not only become key elements in outbreak investigations but could drive a new surveillance paradigm. However, despite the advances made, significant challenges will need to be addressed before next-generation technologies become routine, particularly in low-resource settings. Emerging approaches and techniques such as synthetic genomics, systems genetics, systems biology and mathematical modelling are capable of generating potentially huge volumes of highly complex and diverse datasets. Harnessing the currently theoretical benefits of such bioinformatics ("big data") concepts for the influenza vaccine virus selection and development process will depend upon further advances in data generation, integration, analysis and dissemination. Over the last decade, growing awareness of influenza as an important global public health issue has been coupled to ever-increasing demands from the global community for more-equitable access to effective and affordable influenza vaccines. The current influenza vaccine landscape continues to be dominated by egg-based inactivated and live attenuated vaccines, with a small number of cell-based and recombinant vaccines. Successfully completing each step in the annual influenza vaccine manufacturing cycle will continue to rely upon timely and regular communication between the WHO GISRS, manufacturers and regulatory authorities. While the pipeline of influenza vaccines appears to be moving towards a variety of niche products in the near term, it is apparent that the ultimate aim remains the development of effective "universal" influenza vaccines that offer longer-lasting immunity against a broad range of influenza A subtypes.Influenza vaccine virusesVaccine virus selectionWHO recommendationsVacinas contra Influenzainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014
title Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014
spellingShingle Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014
Ampofo, William K.
Influenza vaccine viruses
Vaccine virus selection
WHO recommendations
Vacinas contra Influenza
title_short Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014
title_full Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014
title_fullStr Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014
title_full_unstemmed Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014
title_sort Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014
author Ampofo, William K.
author_facet Ampofo, William K.
Azziz-Baumgartner, Eduardo
Bashir, Uzma
Cox, Nancy J.
Fasce, Rodrigo
Giovanni, Maria
Grohmann, Gary
Huang, Sue
Katz, Jackie
Mironenko, Alla
Mokhtari-Azad, Talat
Sasono, Pretty Multihartina
Rahman, Mahmudur
Sawanpanyalert, Pathom
Siqueira, Marilda Agudo Mendonça Teixeira de
Waddell, Anthony L.
Waiboci, Lillian
Wood, John
Zhang, Wenqing
Ziegler, Thedi
author_role author
author2 Azziz-Baumgartner, Eduardo
Bashir, Uzma
Cox, Nancy J.
Fasce, Rodrigo
Giovanni, Maria
Grohmann, Gary
Huang, Sue
Katz, Jackie
Mironenko, Alla
Mokhtari-Azad, Talat
Sasono, Pretty Multihartina
Rahman, Mahmudur
Sawanpanyalert, Pathom
Siqueira, Marilda Agudo Mendonça Teixeira de
Waddell, Anthony L.
Waiboci, Lillian
Wood, John
Zhang, Wenqing
Ziegler, Thedi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ampofo, William K.
Azziz-Baumgartner, Eduardo
Bashir, Uzma
Cox, Nancy J.
Fasce, Rodrigo
Giovanni, Maria
Grohmann, Gary
Huang, Sue
Katz, Jackie
Mironenko, Alla
Mokhtari-Azad, Talat
Sasono, Pretty Multihartina
Rahman, Mahmudur
Sawanpanyalert, Pathom
Siqueira, Marilda Agudo Mendonça Teixeira de
Waddell, Anthony L.
Waiboci, Lillian
Wood, John
Zhang, Wenqing
Ziegler, Thedi
dc.subject.en.pt_BR.fl_str_mv Influenza vaccine viruses
Vaccine virus selection
WHO recommendations
topic Influenza vaccine viruses
Vaccine virus selection
WHO recommendations
Vacinas contra Influenza
dc.subject.decs.pt_BR.fl_str_mv Vacinas contra Influenza
description Noguchi Memorial Institute for Medical Research. Accra, Ghana.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-05-12T21:39:57Z
dc.date.available.fl_str_mv 2016-05-12T21:39:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv AMPOFO, William K. et al. Strengthening the influenza vaccine virus selection and development process: Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1-3 April 2014. Vaccine, v.33, n.36, p.4368-4382, Aug. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14264
dc.identifier.issn.none.fl_str_mv 0264-410X
dc.identifier.doi.none.fl_str_mv 10.1016/j.vaccine.2015.06.090
dc.identifier.eissn.none.fl_str_mv 1873-2518
identifier_str_mv AMPOFO, William K. et al. Strengthening the influenza vaccine virus selection and development process: Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1-3 April 2014. Vaccine, v.33, n.36, p.4368-4382, Aug. 2015.
0264-410X
10.1016/j.vaccine.2015.06.090
1873-2518
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dc.language.iso.fl_str_mv eng
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