FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial

Detalhes bibliográficos
Autor(a) principal: Santos, Karina dos
Data de Publicação: 2022
Outros Autores: Rosado, Eliane Lopes, Fonseca, Ana Carolina Proença da, Belfort, Gabriella Pinto, Silva, Letícia Barbosa Gabriel da, Ribeiro-Alves, Marcelo, Zembrzuski, Verônica Marques, Martínez, J. Alfredo, Saunders, Cláudia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/52904
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brasil.
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spelling Santos, Karina dosRosado, Eliane LopesFonseca, Ana Carolina Proença daBelfort, Gabriella PintoSilva, Letícia Barbosa Gabriel daRibeiro-Alves, MarceloZembrzuski, Verônica MarquesMartínez, J. AlfredoSaunders, Cláudia2022-05-25T22:53:16Z2022-05-25T22:53:16Z2022SANTOS, Karina dos et al. FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial. Nutrients, v. 14, n. 5, p. 1-17, 20222072-6643https://www.arca.fiocruz.br/handle/icict/5290410.3390/nu14051050engMDPIFTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.IMDEA Food Institute. Precision Nutrition and Cardiometabolic Health Program. Madrid, Spain.Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brasil.Excessive gestational weight gain (GWG) is associated with increased risk of maternal and neonatal complications. We investigated obesity-related polymorphisms in the FTO gene (rs9939609, rs17817449) and ADRB2 (rs1042713, rs1042714) as candidate risk factors concerning excessive GWG in pregnant women with pregestational diabetes. This nutrigenetic trial, conducted in Brazil, randomly assigned 70 pregnant women to one of the groups: traditional diet (n = 41) or DASH diet (n = 29). Excessive GWG was the total weight gain above the upper limit of the recommendation, according to the Institute of Medicine guidelines. Genotyping was performed using real-time PCR. Time-to-event analysis was performed to investigate risk factors for progression to excessive GWG. Regardless the type of diet, AT carriers of rs9939609 (FTO) and AA carriers of rs1042713 (ADRB2) had higher risk of earlier exceeding GWG compared to TT (aHR 2.44; CI 95% 1.03-5.78; p = 0.04) and GG (aHR 3.91; CI 95% 1.12-13.70; p = 0.03) genotypes, respectively, as the AG carriers for FTO haplotype rs9939609:rs17817449 compared to TT carriers (aHR 1.79; CI 95% 1.04-3.06; p = 0.02).ADRB2DASH dietFTODiabetes mellitusGestational weight gainNutrigeneticsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/52904/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALFTO_Marcelo_Alves_etal_INI_2022.pdfFTO_Marcelo_Alves_etal_INI_2022.pdfapplication/pdf492422https://www.arca.fiocruz.br/bitstream/icict/52904/2/FTO_Marcelo_Alves_etal_INI_2022.pdf546d21c7790cbf37ea095b5a5bffa990MD52icict/529042022-05-25 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dc.title.pt_BR.fl_str_mv FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial
title FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial
spellingShingle FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial
Santos, Karina dos
ADRB2
DASH diet
FTO
Diabetes mellitus
Gestational weight gain
Nutrigenetics
title_short FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial
title_full FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial
title_fullStr FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial
title_full_unstemmed FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial
title_sort FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial
author Santos, Karina dos
author_facet Santos, Karina dos
Rosado, Eliane Lopes
Fonseca, Ana Carolina Proença da
Belfort, Gabriella Pinto
Silva, Letícia Barbosa Gabriel da
Ribeiro-Alves, Marcelo
Zembrzuski, Verônica Marques
Martínez, J. Alfredo
Saunders, Cláudia
author_role author
author2 Rosado, Eliane Lopes
Fonseca, Ana Carolina Proença da
Belfort, Gabriella Pinto
Silva, Letícia Barbosa Gabriel da
Ribeiro-Alves, Marcelo
Zembrzuski, Verônica Marques
Martínez, J. Alfredo
Saunders, Cláudia
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Karina dos
Rosado, Eliane Lopes
Fonseca, Ana Carolina Proença da
Belfort, Gabriella Pinto
Silva, Letícia Barbosa Gabriel da
Ribeiro-Alves, Marcelo
Zembrzuski, Verônica Marques
Martínez, J. Alfredo
Saunders, Cláudia
dc.subject.en.pt_BR.fl_str_mv ADRB2
DASH diet
FTO
Diabetes mellitus
Gestational weight gain
Nutrigenetics
topic ADRB2
DASH diet
FTO
Diabetes mellitus
Gestational weight gain
Nutrigenetics
description Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-05-25T22:53:16Z
dc.date.available.fl_str_mv 2022-05-25T22:53:16Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Karina dos et al. FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial. Nutrients, v. 14, n. 5, p. 1-17, 2022
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/52904
dc.identifier.issn.pt_BR.fl_str_mv 2072-6643
dc.identifier.doi.none.fl_str_mv 10.3390/nu14051050
identifier_str_mv SANTOS, Karina dos et al. FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial. Nutrients, v. 14, n. 5, p. 1-17, 2022
2072-6643
10.3390/nu14051050
url https://www.arca.fiocruz.br/handle/icict/52904
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/52904/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/52904/2/FTO_Marcelo_Alves_etal_INI_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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