Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.

Detalhes bibliográficos
Autor(a) principal: Gama, Kelly Barbosa
Data de Publicação: 2013
Outros Autores: Quintans, Jullyana de Souza Siqueira, Antoniolli, Angelo Roberto, Quintans Junior, Lucindo José, Santana, Wagno Alcântara, Branco, Alexsandro, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1021/np3007342
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8554
Resumo: Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil
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spelling Gama, Kelly BarbosaQuintans, Jullyana de Souza SiqueiraAntoniolli, Angelo RobertoQuintans Junior, Lucindo JoséSantana, Wagno AlcântaraBranco, AlexsandroSoares, Milena Botelho PereiraVillarreal, Cristiane Flora2014-10-08T19:34:21Z2014-10-08T19:34:21Z2013GAMA, K. B. et al. Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. Journal of Natural Products, v. 76, n. 4, p. 559-563, 2013.1520-6025https://www.arca.fiocruz.br/handle/icict/855410.1021/np3007342engACS PublicationsEvidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal de Sergipe. Departamento de Fisiologia. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Departamento de Fisiologia. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Departamento de Fisiologia. Aracaju, SE, BrasilUniversidade Estadual de Feira de Santana. Feira de Santana, BA, BrasilUniversidade Estadual de Feira de Santana. Feira de Santana, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHecogenin is a sapogenin present in the leaves of species from the Agave genus, with a wide spectrum of reported pharmacological activities. The present study was undertaken to evaluate whether hecogenin acetate (1) has antinociceptive properties and to determine its mechanism of action. The nociceptive threshold was evaluated using the tail flick test in mice. Mice motor performance was evaluated in a Rotarod test. By using Fos expression as a marker of neural activation, the involvement of the periaqueductal gray in 1-induced antinociception was evaluated. Intraperitoneal administration of 1 (5−40 mg/kg) produced a dose-dependent increase in the tail flick latency time compared to vehicle-treated group (p < 0.01). Mice treated with 1 (40 mg/kg) did not show motor performance alterations. The antinociception of 1 (40 mg/kg) was prevented by naloxone (nonselective opioid receptor antagonist; 5 mg/kg), CTOP (μ-opioid receptor antagonist; 1 mg/kg), nor-BNI (κ- opioid receptor antagonist; 0.5 mg/kg), naltrindole (δ-opioid receptor antagonist; 3 mg/kg), or glibenclamide (ATP-sensitive K+ channel blocker; 2 mg/kg). Systemic administration of 1 (5−40 mg/kg) increased the number of Fos positive cells in the periaqueductal gray. The present study has demonstrated for the first time that 1 produces consistent antinociception mediated by opioid receptors and endogenous analgesic mechanismsAgave/químicaAnalgésicos/farmacologiaDor/quimioterapiaCompostos de Espiro/farmacologiaEsteroides/farmacologiaAnimaisGlibureto/farmacologiaCanais KATP/antagonistas & inibidoresMasculinoCamundongosEstrutura MolecularNaltrexona/farmacologiaSubstância Cinzenta Periaquedutal/efeitos de drogasFolhas de Planta/químicaReceptores Opioides kappa/antagonistas & inibidoresinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8554/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALGAMA K B Evidence for the....pdfGAMA K B Evidence for the....pdfapplication/pdf623352https://www.arca.fiocruz.br/bitstream/icict/8554/2/GAMA%20K%20B%20Evidence%20for%20the....pdf775057950bf26281a03c9d6374ade542MD52TEXTGAMA K B Evidence for the....pdf.txtGAMA K B Evidence for the....pdf.txtExtracted texttext/plain26975https://www.arca.fiocruz.br/bitstream/icict/8554/3/GAMA%20K%20B%20Evidence%20for%20the....pdf.txt69c27acf81d78c5d48b684bbebbdef4bMD53icict/85542023-03-15 14:32:55.164oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.
title Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.
spellingShingle Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.
Gama, Kelly Barbosa
Agave/química
Analgésicos/farmacologia
Dor/quimioterapia
Compostos de Espiro/farmacologia
Esteroides/farmacologia
Animais
Glibureto/farmacologia
Canais KATP/antagonistas & inibidores
Masculino
Camundongos
Estrutura Molecular
Naltrexona/farmacologia
Substância Cinzenta Periaquedutal/efeitos de drogas
Folhas de Planta/química
Receptores Opioides kappa/antagonistas & inibidores
title_short Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.
title_full Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.
title_fullStr Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.
title_full_unstemmed Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.
title_sort Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.
author Gama, Kelly Barbosa
author_facet Gama, Kelly Barbosa
Quintans, Jullyana de Souza Siqueira
Antoniolli, Angelo Roberto
Quintans Junior, Lucindo José
Santana, Wagno Alcântara
Branco, Alexsandro
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author_role author
author2 Quintans, Jullyana de Souza Siqueira
Antoniolli, Angelo Roberto
Quintans Junior, Lucindo José
Santana, Wagno Alcântara
Branco, Alexsandro
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gama, Kelly Barbosa
Quintans, Jullyana de Souza Siqueira
Antoniolli, Angelo Roberto
Quintans Junior, Lucindo José
Santana, Wagno Alcântara
Branco, Alexsandro
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
dc.subject.decs.pt_BR.fl_str_mv Agave/química
Analgésicos/farmacologia
Dor/quimioterapia
Compostos de Espiro/farmacologia
Esteroides/farmacologia
Animais
Glibureto/farmacologia
Canais KATP/antagonistas & inibidores
Masculino
Camundongos
Estrutura Molecular
Naltrexona/farmacologia
Substância Cinzenta Periaquedutal/efeitos de drogas
Folhas de Planta/química
Receptores Opioides kappa/antagonistas & inibidores
topic Agave/química
Analgésicos/farmacologia
Dor/quimioterapia
Compostos de Espiro/farmacologia
Esteroides/farmacologia
Animais
Glibureto/farmacologia
Canais KATP/antagonistas & inibidores
Masculino
Camundongos
Estrutura Molecular
Naltrexona/farmacologia
Substância Cinzenta Periaquedutal/efeitos de drogas
Folhas de Planta/química
Receptores Opioides kappa/antagonistas & inibidores
description Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-10-08T19:34:21Z
dc.date.available.fl_str_mv 2014-10-08T19:34:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GAMA, K. B. et al. Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. Journal of Natural Products, v. 76, n. 4, p. 559-563, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8554
dc.identifier.issn.none.fl_str_mv 1520-6025
dc.identifier.doi.none.fl_str_mv 10.1021/np3007342
identifier_str_mv GAMA, K. B. et al. Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. Journal of Natural Products, v. 76, n. 4, p. 559-563, 2013.
1520-6025
10.1021/np3007342
url https://www.arca.fiocruz.br/handle/icict/8554
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ACS Publications
publisher.none.fl_str_mv ACS Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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