Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice
| Autor(a) principal: | |
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| Data de Publicação: | 2000 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/6362 |
Resumo: | PAPES/FIOCRUZ, FINEP, CNPq/RHAE,INSERM/FIOCRUZ, CAPES-COFECUB Institut Pasteur/INSERM |
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Elsas, Maria Ignez Capella GasparMaximiniano, Elisabeth S.Joseph, DanielleAlves, LetíciaTopilko, AndrzejVargaftig, B. BorisXavier-Elsas, Pedro Paulo2013-03-11T14:29:27Z2013-03-11T14:29:27Z2000ELSAS, Maria Ignez C. Gaspar et al. Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice. Br. j. clin. pharmacol., London, v. 129, n. 8, p. 1543-1552, apr. 2000.1365-2125https://www.arca.fiocruz.br/handle/icict/6362PAPES/FIOCRUZ, FINEP, CNPq/RHAE,INSERM/FIOCRUZ, CAPES-COFECUB Institut Pasteur/INSERMFundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pesquisa. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilINSERM. Unité Associeé Institut Pasteur. Uniteé de Pharmacologie Cellulaire. Paris, FranceUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilInstitut Pasteur. Station Centrale de Microscopie Électronique. Paris, FranceINSERM. Unité Associeé Institut Pasteur. Uniteé de Pharmacologie Cellulaire. Paris, FranceUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilSince the production of eosinopoietic cytokines (GM-CSF, IL-3, IL-5) is inhibited by glucocorticoids, while responsiveness to these cytokines is enhanced in bone-marrow of allergic mice, we studied the ability of glucocorticoids to modulate murine bone-marrow eosinopoiesis. Progenitor (semi-solid) and/or precursor (liquid) cultures were established from bone-marrow of: (a) normal mice; (b) ovalbumin-sensitized and challenged mice or (c) dexamethasone (1-5 mg kg(-1)) injected mice. Cultures were established with GM-CSF (2 ng ml(-1)) or IL-5 (1 ng ml(-1)), respectively, alone or associated with dexamethasone, hydrocortisone or corticosterone. Total myeloid colony numbers, frequency and size of eosinophil colonies, and numbers of eosinophil-peroxidase-positive cells were determined at day 7. In BALB/c mice, dexamethasone (10(-7) M) increased GM-CSF-stimulated myeloid colony formation (P = 0.01), as well as the frequency (P=0.01) and size (P<0.01) of eosinophil colonies. Dexamethasone (10(-7) M) alone had no effect. Dexamethasone (10(-7)-10(-10) M) increased (P<0.002) eosinophil precursor responses to IL-5. Potentiation by dexamethasone was still detectable: (a) on low density, immature, nonadherent BALB/c bone-marrow cells, (b) on bone-marrow from other strains, and (c) on cells from allergic mice. Hydrocortisone and corticosterone had similar effects. Dexamethasone administered in vivo, 24 h before bone-marrow harvest, increased subsequent progenitor responses to GM-CSF (P = 0.001) and precursor responses to IL-5 (P<0.001). These effects were blocked by RU 486 (20 mg kg(-1), orally, 2 h before dexamethasone, or added in vitro at 10 microM, P<0.001). Glucocorticoids, acting in vivo or in vitro, through glucocorticoid receptors, enhance bone-marrow eosinopoiesis in naïve and allergic mice.engBlackwell Scientific PublicationsAGARWAL, S.K. &MARSHALL, G.D. (1998). Glucocorticoid-induced Type 1/Type 2 cytokine alterations in humans: a model for stress- related immune dysfunction. J. Interferon Cytokine Res., 18, 1059 - 1068.BAGBY, G.C. (1994). Hematopoiesis. In: Stamatoyannopoulos, G., Nienhuis, A.W.,Majerus, P.W., Varmus H. (eds.), TheMolecular Basis of Blood Diseases (2nd. Ed.), W.B. Saunders, Philadelphia, pp. 71 - 106.BARNES, P.J. (1996). Molecular mechanisms of steroid action in asthma. J. Allergy Clin. Immunol., 97, 159 - 168.BARR, D.D., VOLARIC, Z. & KLIM, J.B. (1987). Stimulation of human eosinophilopoiesis by hydrocortisone in vitro. Acta Haematol., 77, 20 - 24.BEGLEY, C.G., BASSER, R., MANSFIELD, R., THOMSON, B., PARKER, W.R.L., LAYTON, J., TO, B., CEBON, J., SHERIDAN, W.P., FOX, R.M. & GREEN, M.D. (1997). Enhanced levels and enhanced clonogenic capacity of blood progenitor cells following administration of stem cell factor plus granulocyte colony stimulating factor to humans. Blood, 90, 3378 - 3389.BUTTERFIELD, J.H., ACKERMAN, S.J., WEILER, D., EISENBREY, A.B. & GLEICH, G.J. (1986). E ects of glucocorticoids on eosinophil colony growth. J. Allergy Clin. Immunol., 78, 450 - 457.CLUTTERBUCK, E.J., HIRST, E.M.A. & SANDERSON, C.J. (1989). Human Interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GM-CSF. Blood, 73, 1504 - 1512.DAS, A.M., FLOWER, R.J., HELLEWELL, P.G., TEIXEIRA, M. & PERRETTI, M. (1997). A novel murine model of allergic in¯ammation to study the e ect of Dexamethasone on eosinophil recruitment. Br. J. 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| dc.title.pt_BR.fl_str_mv |
Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice |
| title |
Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice |
| spellingShingle |
Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice Elsas, Maria Ignez Capella Gaspar Glucocorticoids Eosinophil GM-CSF IL-5 Bone-marrow Citocinas Glucocorticóides Hipersensibilidade Receptores de Glucocorticóides |
| title_short |
Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice |
| title_full |
Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice |
| title_fullStr |
Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice |
| title_full_unstemmed |
Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice |
| title_sort |
Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice |
| author |
Elsas, Maria Ignez Capella Gaspar |
| author_facet |
Elsas, Maria Ignez Capella Gaspar Maximiniano, Elisabeth S. Joseph, Danielle Alves, Letícia Topilko, Andrzej Vargaftig, B. Boris Xavier-Elsas, Pedro Paulo |
| author_role |
author |
| author2 |
Maximiniano, Elisabeth S. Joseph, Danielle Alves, Letícia Topilko, Andrzej Vargaftig, B. Boris Xavier-Elsas, Pedro Paulo |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Elsas, Maria Ignez Capella Gaspar Maximiniano, Elisabeth S. Joseph, Danielle Alves, Letícia Topilko, Andrzej Vargaftig, B. Boris Xavier-Elsas, Pedro Paulo |
| dc.subject.en.pt_BR.fl_str_mv |
Glucocorticoids Eosinophil GM-CSF IL-5 Bone-marrow |
| topic |
Glucocorticoids Eosinophil GM-CSF IL-5 Bone-marrow Citocinas Glucocorticóides Hipersensibilidade Receptores de Glucocorticóides |
| dc.subject.decs.pt_BR.fl_str_mv |
Citocinas Glucocorticóides Hipersensibilidade Receptores de Glucocorticóides |
| description |
PAPES/FIOCRUZ, FINEP, CNPq/RHAE,INSERM/FIOCRUZ, CAPES-COFECUB Institut Pasteur/INSERM |
| publishDate |
2000 |
| dc.date.issued.fl_str_mv |
2000 |
| dc.date.accessioned.fl_str_mv |
2013-03-11T14:29:27Z |
| dc.date.available.fl_str_mv |
2013-03-11T14:29:27Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
ELSAS, Maria Ignez C. Gaspar et al. Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice. Br. j. clin. pharmacol., London, v. 129, n. 8, p. 1543-1552, apr. 2000. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/6362 |
| dc.identifier.issn.none.fl_str_mv |
1365-2125 |
| identifier_str_mv |
ELSAS, Maria Ignez C. Gaspar et al. Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice. Br. j. clin. pharmacol., London, v. 129, n. 8, p. 1543-1552, apr. 2000. 1365-2125 |
| url |
https://www.arca.fiocruz.br/handle/icict/6362 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.isbasedon.pt_BR.fl_str_mv |
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