Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12709 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. |
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Meis, Juliana deAlbuquerque, Juliana Barreto deSantos, Danielle Silva dosOliveira, Désio Aurélio Farias deBerbert, Luiz RicardoAlmeida, Vinicius Cotta deSavino, Wilson2016-02-07T22:02:49Z2016-02-07T22:02:49Z2013MEIS, Juliana de; et al. Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice. Frontiers in Immunology, v.4, Article 216, 7p, July 2013.1664-3224https://www.arca.fiocruz.br/handle/icict/1270910.3389/fimmu.2013.00216engFrontiersTrypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, BrasilAcute Chagas disease is characterized by a systemic infection that leads to the strong activation of the adaptive immune response. Outbreaks of oral contamination by the infective protozoan Trypanosoma cruzi are frequent in Brazil and other Latin American countries, and an increased severity of clinical manifestations and mortality is observed in infected patients. These findings have elicited questions about the specific responses triggered after T. cruzi entry via mucosal sites, possibly modulating local immune mechanisms, and further impacting regional and systemic immunity. Here, we provide evidence for the existence of differential lymphoid organ responses in experimental models of acute T. cruzi infection.Trypanosoma cruzSpleenCytokineT cell activationTrypanosoma cruzCitocinasLinfonodosBaçoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12709/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjuliana2_demeis_etal_IOC_2013.pdfjuliana2_demeis_etal_IOC_2013.pdfapplication/pdf590940https://www.arca.fiocruz.br/bitstream/icict/12709/2/juliana2_demeis_etal_IOC_2013.pdf6cfe3971464389bf8aa06f9ff23d88efMD52TEXTjuliana2_demeis_etal_IOC_2013.pdf.txtjuliana2_demeis_etal_IOC_2013.pdf.txtExtracted texttext/plain47163https://www.arca.fiocruz.br/bitstream/icict/12709/3/juliana2_demeis_etal_IOC_2013.pdf.txt9e8dc456d4840d3a9280dfa902446d04MD53icict/127092022-06-24 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| dc.title.pt_BR.fl_str_mv |
Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice |
| title |
Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice |
| spellingShingle |
Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice Meis, Juliana de Trypanosoma cruz Spleen Cytokine T cell activation Trypanosoma cruz Citocinas Linfonodos Baço |
| title_short |
Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice |
| title_full |
Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice |
| title_fullStr |
Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice |
| title_full_unstemmed |
Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice |
| title_sort |
Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice |
| author |
Meis, Juliana de |
| author_facet |
Meis, Juliana de Albuquerque, Juliana Barreto de Santos, Danielle Silva dos Oliveira, Désio Aurélio Farias de Berbert, Luiz Ricardo Almeida, Vinicius Cotta de Savino, Wilson |
| author_role |
author |
| author2 |
Albuquerque, Juliana Barreto de Santos, Danielle Silva dos Oliveira, Désio Aurélio Farias de Berbert, Luiz Ricardo Almeida, Vinicius Cotta de Savino, Wilson |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Meis, Juliana de Albuquerque, Juliana Barreto de Santos, Danielle Silva dos Oliveira, Désio Aurélio Farias de Berbert, Luiz Ricardo Almeida, Vinicius Cotta de Savino, Wilson |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruz Spleen Cytokine T cell activation |
| topic |
Trypanosoma cruz Spleen Cytokine T cell activation Trypanosoma cruz Citocinas Linfonodos Baço |
| dc.subject.decs.pt_BR.fl_str_mv |
Trypanosoma cruz Citocinas Linfonodos Baço |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2013 |
| dc.date.issued.fl_str_mv |
2013 |
| dc.date.accessioned.fl_str_mv |
2016-02-07T22:02:49Z |
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2016-02-07T22:02:49Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
MEIS, Juliana de; et al. Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice. Frontiers in Immunology, v.4, Article 216, 7p, July 2013. |
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https://www.arca.fiocruz.br/handle/icict/12709 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2013.00216 |
| identifier_str_mv |
MEIS, Juliana de; et al. Trypanosoma cruzi entrance through systemic or mucosal infection sites differentially modulates regional immune response following acute infection in mice. Frontiers in Immunology, v.4, Article 216, 7p, July 2013. 1664-3224 10.3389/fimmu.2013.00216 |
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Frontiers |
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