Non-permissive SARS-CoV-2 infection in human neurospheres
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50755 |
Resumo: | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
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Pedrosa, Carolina da S.G.Silva, Livia GotoTemerozo, Jairo RamosSouza, Leticia Rocha QuintinoVitória, GabrielaOrnelas, Isis M.Karmirian, KarinaMendes, Mayara A.Gomes, Ismael C.Sacramento, Carolina Q.Rodrigues, Natalia FintelmanSoares, Vinicius CardosoDias, Suelen da Silva GomesSalerno, José A.Puig-Pijuan, TeresaOliveira, Julia T.Aragão, Luiz G. H. S.Torquato, Thayana C. Q.Veríssimo, Carla PiresBiagi, DiogoCruvinel, Estela M.Dariolli, RafaelFurtado, Daniel R.Borges, Helena L.Bozza, Patrícia TorresRehen, StevensSouza, Thiago Moreno L.Guimarães, Marília Zaluar P.2022-01-14T14:34:45Z2022-01-14T14:34:45Z2021PEDROSA, Carolina da S. G. et al. Non-permissive SARS-CoV-2 infection in human neurospheres. Stem Cell Resarch, v. 54, 102436, p. 1-13, June 2021.1873-5061https://www.arca.fiocruz.br/handle/icict/5075510.1016/j.scr.2021.102436Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia em Inovação em Doenças de Populações Negligenciadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia em Inovação em Doenças de Populações Negligenciadas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil /Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Pluricell Biotech.São Paulo, SP, Brasil.Pluricell Biotech.São Paulo, SP, Brasil.Pluricell Biotech.São Paulo, SP, Brasil / Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai. New York, NY, USA.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia em Inovação em Doenças de Populações Negligenciadas. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia em Inovação em Doenças de Populações Negligenciadas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Programa de Imunologia e Inflamação. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but the neurotropic potential of the virus is still debated. Herein, we sought to investigate SARS-CoV-2 infection in human neural cells. We demonstrated that SARS-CoV-2 infection of neural tissue is non-permissive, however, it can elicit inflammatory response and cell damage. These findings add to the hypothesis that most of the neural damage caused by SARS-CoV-2 infection is due to a systemic inflammation leading to indirect harmful effects on the central nervous system despite the absence of local viral replication.engElsevierhttps://www.arca.fiocruz.br/handle/icict/53586SARS-CoV-2Novo CoronavírusCérebroNeuroesferasNew coronavirusBrainNeurospheresSARS-CoV-2iPSNon-permissive SARS-CoV-2 infection in human neurospheresinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Non-permissive SARS-CoV-2 infection in human neurospheres |
| title |
Non-permissive SARS-CoV-2 infection in human neurospheres |
| spellingShingle |
Non-permissive SARS-CoV-2 infection in human neurospheres Pedrosa, Carolina da S.G. SARS-CoV-2 Novo Coronavírus Cérebro Neuroesferas New coronavirus Brain Neurospheres SARS-CoV-2 iPS |
| title_short |
Non-permissive SARS-CoV-2 infection in human neurospheres |
| title_full |
Non-permissive SARS-CoV-2 infection in human neurospheres |
| title_fullStr |
Non-permissive SARS-CoV-2 infection in human neurospheres |
| title_full_unstemmed |
Non-permissive SARS-CoV-2 infection in human neurospheres |
| title_sort |
Non-permissive SARS-CoV-2 infection in human neurospheres |
| author |
Pedrosa, Carolina da S.G. |
| author_facet |
Pedrosa, Carolina da S.G. Silva, Livia Goto Temerozo, Jairo Ramos Souza, Leticia Rocha Quintino Vitória, Gabriela Ornelas, Isis M. Karmirian, Karina Mendes, Mayara A. Gomes, Ismael C. Sacramento, Carolina Q. Rodrigues, Natalia Fintelman Soares, Vinicius Cardoso Dias, Suelen da Silva Gomes Salerno, José A. Puig-Pijuan, Teresa Oliveira, Julia T. Aragão, Luiz G. H. S. Torquato, Thayana C. Q. Veríssimo, Carla Pires Biagi, Diogo Cruvinel, Estela M. Dariolli, Rafael Furtado, Daniel R. Borges, Helena L. Bozza, Patrícia Torres Rehen, Stevens Souza, Thiago Moreno L. Guimarães, Marília Zaluar P. |
| author_role |
author |
| author2 |
Silva, Livia Goto Temerozo, Jairo Ramos Souza, Leticia Rocha Quintino Vitória, Gabriela Ornelas, Isis M. Karmirian, Karina Mendes, Mayara A. Gomes, Ismael C. Sacramento, Carolina Q. Rodrigues, Natalia Fintelman Soares, Vinicius Cardoso Dias, Suelen da Silva Gomes Salerno, José A. Puig-Pijuan, Teresa Oliveira, Julia T. Aragão, Luiz G. H. S. Torquato, Thayana C. Q. Veríssimo, Carla Pires Biagi, Diogo Cruvinel, Estela M. Dariolli, Rafael Furtado, Daniel R. Borges, Helena L. Bozza, Patrícia Torres Rehen, Stevens Souza, Thiago Moreno L. Guimarães, Marília Zaluar P. |
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author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pedrosa, Carolina da S.G. Silva, Livia Goto Temerozo, Jairo Ramos Souza, Leticia Rocha Quintino Vitória, Gabriela Ornelas, Isis M. Karmirian, Karina Mendes, Mayara A. Gomes, Ismael C. Sacramento, Carolina Q. Rodrigues, Natalia Fintelman Soares, Vinicius Cardoso Dias, Suelen da Silva Gomes Salerno, José A. Puig-Pijuan, Teresa Oliveira, Julia T. Aragão, Luiz G. H. S. Torquato, Thayana C. Q. Veríssimo, Carla Pires Biagi, Diogo Cruvinel, Estela M. Dariolli, Rafael Furtado, Daniel R. Borges, Helena L. Bozza, Patrícia Torres Rehen, Stevens Souza, Thiago Moreno L. Guimarães, Marília Zaluar P. |
| dc.subject.other.pt_BR.fl_str_mv |
SARS-CoV-2 Novo Coronavírus Cérebro Neuroesferas |
| topic |
SARS-CoV-2 Novo Coronavírus Cérebro Neuroesferas New coronavirus Brain Neurospheres SARS-CoV-2 iPS |
| dc.subject.en.pt_BR.fl_str_mv |
New coronavirus Brain Neurospheres SARS-CoV-2 iPS |
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Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
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2021 |
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2021 |
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2022-01-14T14:34:45Z |
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2022-01-14T14:34:45Z |
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PEDROSA, Carolina da S. G. et al. Non-permissive SARS-CoV-2 infection in human neurospheres. Stem Cell Resarch, v. 54, 102436, p. 1-13, June 2021. |
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https://www.arca.fiocruz.br/handle/icict/50755 |
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1873-5061 |
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10.1016/j.scr.2021.102436 |
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PEDROSA, Carolina da S. G. et al. Non-permissive SARS-CoV-2 infection in human neurospheres. Stem Cell Resarch, v. 54, 102436, p. 1-13, June 2021. 1873-5061 10.1016/j.scr.2021.102436 |
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