Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study

Detalhes bibliográficos
Autor(a) principal: Miranda, Cláudia Madeira
Data de Publicação: 2022
Outros Autores: Silva, Rose Mary Ferreira Lisboa da, Pascoal, Vanessa Peruhybe Magalhães, Brugada, Josep
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56514
Resumo: Faculty of Medicine. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil/Madre Teresa Hospital. Belo Horizonte, MG, Brazil.
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spelling Miranda, Cláudia MadeiraSilva, Rose Mary Ferreira Lisboa daPascoal, Vanessa Peruhybe MagalhãesBrugada, Josep2023-01-19T15:40:32Z2023-01-19T15:40:32Z2022MIRANDA, Cláudia Madeira et al. Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study. Clin Med Insights Cardiol., v. 16, 11795468221116848, 2022. doi: 10.1177/11795468221116848.1179-5468https://www.arca.fiocruz.br/handle/icict/56514engSAGE PublicationsVasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFaculty of Medicine. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil/Madre Teresa Hospital. Belo Horizonte, MG, Brazil.Faculty of Medicine. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Oswaldo Cruz Foundation. René Rachou Institute. Belo Horizonte, MG, Brazil.Institut Clínic Cardiovascular. Hospital Clínic. Universitat de Barcelona. Barcelona, Spain.Background: Vasovagal syncope (VVS) is the most common cause of syncope. Some stages of its pathophysiological mechanisms remain unclear. Vasoactive substances such as nitric oxide metabolites (NOx) and endothelin (ET) may be involved during acute orthostatic stress. Objective: To analyze plasma changes in NOx and ET and heart rate variability (HRV) in the supine positions (T1) and during the head-up tilt test (HUTT) (T2), in patients with VVS (case group) and control group. Methods: Thirty-seven patients (17 in the case group and 20 in the control group), matched for age and sex (mean aged 31.8 years) underwent HUTT with simultaneous HRV recording and venipuncture. Blood samples were collected during phases T1 and T2 and the analysis was performed without knowledge of the HUTT result. Results: In the total sample, there was an increase in NOx values (P = .014), however there was no increase in ET values from phase T1 to phase T2. Patients with VVS tended to increase plasma NOx values (P = .057) and had significantly higher plasma values compared to ET (P = .033) between phases T1 to T2. In the control group, there was no significant change in the values of these vasoactive substances. Regarding HRV, there were a decrease in the component HF (high frequency) and increased of the LF (low frequency)/HF ratio during HUTT. Conclusions: There was an increase in ET during HUTT occurred only in the case group. These patients are more likely to have an imbalance between antagonistic vasoactive biomarkers during orthostatic stress.Vasovagal syncopeautonomic nervous systemendothelinhead-up tilt testnitric oxidevasoactive agentsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56514/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVasoactive Biomarkers in Patients With Vasovagal.pdfVasoactive Biomarkers in Patients With Vasovagal.pdfapplication/pdf4707286https://www.arca.fiocruz.br/bitstream/icict/56514/2/Vasoactive%20Biomarkers%20in%20Patients%20With%20Vasovagal.pdf35df0347e20bfc6b5863785723f2248cMD52icict/565142023-01-19 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dc.title.en_US.fl_str_mv Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study
title Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study
spellingShingle Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study
Miranda, Cláudia Madeira
Vasovagal syncope
autonomic nervous system
endothelin
head-up tilt test
nitric oxide
vasoactive agents
title_short Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study
title_full Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study
title_fullStr Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study
title_full_unstemmed Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study
title_sort Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study
author Miranda, Cláudia Madeira
author_facet Miranda, Cláudia Madeira
Silva, Rose Mary Ferreira Lisboa da
Pascoal, Vanessa Peruhybe Magalhães
Brugada, Josep
author_role author
author2 Silva, Rose Mary Ferreira Lisboa da
Pascoal, Vanessa Peruhybe Magalhães
Brugada, Josep
author2_role author
author
author
dc.contributor.author.fl_str_mv Miranda, Cláudia Madeira
Silva, Rose Mary Ferreira Lisboa da
Pascoal, Vanessa Peruhybe Magalhães
Brugada, Josep
dc.subject.en.en_US.fl_str_mv Vasovagal syncope
autonomic nervous system
endothelin
head-up tilt test
nitric oxide
vasoactive agents
topic Vasovagal syncope
autonomic nervous system
endothelin
head-up tilt test
nitric oxide
vasoactive agents
description Faculty of Medicine. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil/Madre Teresa Hospital. Belo Horizonte, MG, Brazil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-19T15:40:32Z
dc.date.available.fl_str_mv 2023-01-19T15:40:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MIRANDA, Cláudia Madeira et al. Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study. Clin Med Insights Cardiol., v. 16, 11795468221116848, 2022. doi: 10.1177/11795468221116848.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56514
dc.identifier.issn.en_US.fl_str_mv 1179-5468
identifier_str_mv MIRANDA, Cláudia Madeira et al. Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study. Clin Med Insights Cardiol., v. 16, 11795468221116848, 2022. doi: 10.1177/11795468221116848.
1179-5468
url https://www.arca.fiocruz.br/handle/icict/56514
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56514/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56514/2/Vasoactive%20Biomarkers%20in%20Patients%20With%20Vasovagal.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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