Variation sites at the HLA-G 3' untranslated region confer differential susceptibility to HIV/HPV co-infection and aneuploidy in cervical cell
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32404 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil. |
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Medeiros, Fernanda SilvaMartins, Albert Eduardo SilvaGomes, Renan GarciaOliveira, Sávio Augusto Vieira deWelkovic, StefanMaruza, MagdaMenezes, Maria Luiza BezerraXimenes, Ricardo Arraes de AlencarDiniz, George Tadeu NunesDonadi, Eduardo AntônioLucena-Silva, Norma2019-04-08T12:43:47Z2019-04-08T12:43:47Z2018MEDEIROS, F. S. et al. Variation Sites at the HLA-G 3’ Untranslated Region Confer Differential Susceptibility to HIV/HPV Co-Infection and Aneuploidy in Cervical Cell. PloS One, v. 13, n. 10, p. 1-14, 2018.1932-6203https://www.arca.fiocruz.br/handle/icict/3240410.1371/journal.pone.0204679engVariation sites at the HLA-G 3' untranslated region confer differential susceptibility to HIV/HPV co-infection and aneuploidy in cervical cellinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil.University of Pernambuco. Integrated Health Centre Amaury de Medeiros. Recife, PE, Brazil.Health Secretariat of Pernambuco. Hospital Correia Picanço. Recife, PE, Brazil.University of Pernambuco. Maternal and Child Department of the Faculty of Medical Sciences. Recife, PE, Brazil.Federal University of Pernambuco. Department of Tropical Medicine. Recife, PE, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Pública. Laboratório de Métodos Computacionais. Recife, PE, Brazil.University of São Paulo. School of Medicine of Ribeirão Preto. Department of Medicine. Ribeirão Preto, SP, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil / IMIP Hospital. Pediatric Oncology Service. Recife, PE, Brazil.Post-transcriptional regulatory elements associated with transcript degradation or transcript instability have been described at the 3' untranslated region (3'UTR) of the HLA-G gene. Considering that HPV infection and aneuploidy, which causes gene instability, are associated with cervical cell malignancy, as well as the fact that HIV infection and HLA-G may modulate the immune response, the present study aimed to compare the frequencies of HLA-G 3'UTR polymorphic sites (14-base pair insertion/deletion, +3142C/G, and +3187A/G) between 226 HIV+ women co-infected (n = 82) or not with HPV (n = 144) and 138 healthy women. We also evaluated the relationship between those HLA-G 3'UTR variants and aneuploidy in cervical cells. HPV types and HLA-G polymorphisms were determined by PCR and sequencing of cervical samples DNA. Aneuploidy in cervical cell was measured by flow cytometry. The HLA-G 3'UTR 14-bp ins/del was not associated with either HIV nor HIV/HPV co-infection. The +3142G allele (p = 0.049) and +3142GG genotype (p = 0.047) were overrepresented in all HIV-infected women. On the other hand, the +3187G allele (p = 0.028) and the +3187GG genotype (p = 0.026) predominated among healthy women. The +3142G (p = 0.023) and +3187A (p = 0.003) alleles were associated with predisposition to HIV infection, irrespective of the presence or not of HIV/HPV co-infection. The diplotype formed by the combination of the +3142CX (CC or CG) and +3187AA genotype conferred the highest risk for aneuploidy in cervical cell induced by HPV. The HLA-G 3'UTR +3142 and +3187 variants conferred distinct susceptibility to HIV infection and aneuploidy.HLA-G 3'HIV/HPVAneuploidy in cervical cell3 'Regiões não traduzidasAdultoAneuploidiaBrasilEstudos de caso-controleCervix Uteri / imunologiaUteri do colo do útero / virologiaCoinfecção / genéticaCoinfecção / imunologiaFêmeaPredisposição Genética para DoençaInfecções por HIV / genéticaInfecções por HIV / imunologiaAntígenos HLA-G / genéticaHumanosInfecções por papilomavírus / genéticaInfecções por papilomavírus / imunologiaPolimorfismo Genéticoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83094https://www.arca.fiocruz.br/bitstream/icict/32404/1/license.txtee3692f7b0b97d5638099ab94397d05fMD51ORIGINALvariation sites at the.pdfvariation sites at 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| dc.title.pt_BR.fl_str_mv |
Variation sites at the HLA-G 3' untranslated region confer differential susceptibility to HIV/HPV co-infection and aneuploidy in cervical cell |
| title |
Variation sites at the HLA-G 3' untranslated region confer differential susceptibility to HIV/HPV co-infection and aneuploidy in cervical cell |
| spellingShingle |
Variation sites at the HLA-G 3' untranslated region confer differential susceptibility to HIV/HPV co-infection and aneuploidy in cervical cell Medeiros, Fernanda Silva HLA-G 3' HIV/HPV Aneuploidy in cervical cell 3 'Regiões não traduzidas Adulto Aneuploidia Brasil Estudos de caso-controle Cervix Uteri / imunologia Uteri do colo do útero / virologia Coinfecção / genética Coinfecção / imunologia Fêmea Predisposição Genética para Doença Infecções por HIV / genética Infecções por HIV / imunologia Antígenos HLA-G / genética Humanos Infecções por papilomavírus / genética Infecções por papilomavírus / imunologia Polimorfismo Genético |
| title_short |
Variation sites at the HLA-G 3' untranslated region confer differential susceptibility to HIV/HPV co-infection and aneuploidy in cervical cell |
| title_full |
Variation sites at the HLA-G 3' untranslated region confer differential susceptibility to HIV/HPV co-infection and aneuploidy in cervical cell |
| title_fullStr |
Variation sites at the HLA-G 3' untranslated region confer differential susceptibility to HIV/HPV co-infection and aneuploidy in cervical cell |
| title_full_unstemmed |
Variation sites at the HLA-G 3' untranslated region confer differential susceptibility to HIV/HPV co-infection and aneuploidy in cervical cell |
| title_sort |
Variation sites at the HLA-G 3' untranslated region confer differential susceptibility to HIV/HPV co-infection and aneuploidy in cervical cell |
| author |
Medeiros, Fernanda Silva |
| author_facet |
Medeiros, Fernanda Silva Martins, Albert Eduardo Silva Gomes, Renan Garcia Oliveira, Sávio Augusto Vieira de Welkovic, Stefan Maruza, Magda Menezes, Maria Luiza Bezerra Ximenes, Ricardo Arraes de Alencar Diniz, George Tadeu Nunes Donadi, Eduardo Antônio Lucena-Silva, Norma |
| author_role |
author |
| author2 |
Martins, Albert Eduardo Silva Gomes, Renan Garcia Oliveira, Sávio Augusto Vieira de Welkovic, Stefan Maruza, Magda Menezes, Maria Luiza Bezerra Ximenes, Ricardo Arraes de Alencar Diniz, George Tadeu Nunes Donadi, Eduardo Antônio Lucena-Silva, Norma |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Medeiros, Fernanda Silva Martins, Albert Eduardo Silva Gomes, Renan Garcia Oliveira, Sávio Augusto Vieira de Welkovic, Stefan Maruza, Magda Menezes, Maria Luiza Bezerra Ximenes, Ricardo Arraes de Alencar Diniz, George Tadeu Nunes Donadi, Eduardo Antônio Lucena-Silva, Norma |
| dc.subject.en.pt_BR.fl_str_mv |
HLA-G 3' HIV/HPV Aneuploidy in cervical cell |
| topic |
HLA-G 3' HIV/HPV Aneuploidy in cervical cell 3 'Regiões não traduzidas Adulto Aneuploidia Brasil Estudos de caso-controle Cervix Uteri / imunologia Uteri do colo do útero / virologia Coinfecção / genética Coinfecção / imunologia Fêmea Predisposição Genética para Doença Infecções por HIV / genética Infecções por HIV / imunologia Antígenos HLA-G / genética Humanos Infecções por papilomavírus / genética Infecções por papilomavírus / imunologia Polimorfismo Genético |
| dc.subject.decs.pt_BR.fl_str_mv |
3 'Regiões não traduzidas Adulto Aneuploidia Brasil Estudos de caso-controle Cervix Uteri / imunologia Uteri do colo do útero / virologia Coinfecção / genética Coinfecção / imunologia Fêmea Predisposição Genética para Doença Infecções por HIV / genética Infecções por HIV / imunologia Antígenos HLA-G / genética Humanos Infecções por papilomavírus / genética Infecções por papilomavírus / imunologia Polimorfismo Genético |
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Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil. |
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2018 |
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2018 |
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2019-04-08T12:43:47Z |
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2019-04-08T12:43:47Z |
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info:eu-repo/semantics/article |
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MEDEIROS, F. S. et al. Variation Sites at the HLA-G 3’ Untranslated Region Confer Differential Susceptibility to HIV/HPV Co-Infection and Aneuploidy in Cervical Cell. PloS One, v. 13, n. 10, p. 1-14, 2018. |
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https://www.arca.fiocruz.br/handle/icict/32404 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0204679 |
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MEDEIROS, F. S. et al. Variation Sites at the HLA-G 3’ Untranslated Region Confer Differential Susceptibility to HIV/HPV Co-Infection and Aneuploidy in Cervical Cell. PloS One, v. 13, n. 10, p. 1-14, 2018. 1932-6203 10.1371/journal.pone.0204679 |
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