Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?

Detalhes bibliográficos
Autor(a) principal: Bianchi, Martina
Data de Publicação: 2020
Outros Autores: Benvenuto, Domenico, Giovanetti, Marta, Angeletti, Silvia, Ciccozzi, Massimo, Pascarella, Stefano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42416
Resumo: Sapienza University of Rome. Department of Biochemical sciences “A Rossi Fanelli”. Rome, Italy.
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spelling Bianchi, MartinaBenvenuto, DomenicoGiovanetti, MartaAngeletti, SilviaCiccozzi, MassimoPascarella, Stefano2020-07-27T20:51:10Z2020-07-27T20:51:10Z2020BIANCHI, Martina et al. Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics? Biomed Research International, v. 2020, Article ID 4389089, p. 1-6, 2020.2314-6133https://www.arca.fiocruz.br/handle/icict/4241610.1155/2020/43890892314-6141engHindawi Publishing CorporationSARS-CoV-2Envelope SARS-CoV-2Proteínas de membranaEstruturais DiferençasCaracterísticas do vírusCOVID-19SARS-CoV-2Envelope and Membrane proteinsStructural DifferencesVirus CharacteristicsCOVID-19Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSapienza University of Rome. Department of Biochemical sciences “A Rossi Fanelli”. Rome, Italy.University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.University Campus Bio-Medico of Rome. Unit of Clinical Laboratory Science. Rome, Italy.University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.Sapienza University of Rome. Department of Biochemical sciences “A Rossi Fanelli”. Rome, Italy.The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42416/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMartaGiovanetti_MartinaBianchi_etal_IOC_2020.pdfMartaGiovanetti_MartinaBianchi_etal_IOC_2020.pdfapplication/pdf1332792https://www.arca.fiocruz.br/bitstream/icict/42416/2/MartaGiovanetti_MartinaBianchi_etal_IOC_2020.pdfec9ac99f711c57c9e3072e5aa905e1daMD52TEXTMartaGiovanetti_MartinaBianchi_etal_IOC_2020.pdf.txtMartaGiovanetti_MartinaBianchi_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
title Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
spellingShingle Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
Bianchi, Martina
SARS-CoV-2
Envelope SARS-CoV-2
Proteínas de membrana
Estruturais Diferenças
Características do vírus
COVID-19
SARS-CoV-2
Envelope and Membrane proteins
Structural Differences
Virus Characteristics
COVID-19
title_short Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
title_full Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
title_fullStr Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
title_full_unstemmed Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
title_sort Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?
author Bianchi, Martina
author_facet Bianchi, Martina
Benvenuto, Domenico
Giovanetti, Marta
Angeletti, Silvia
Ciccozzi, Massimo
Pascarella, Stefano
author_role author
author2 Benvenuto, Domenico
Giovanetti, Marta
Angeletti, Silvia
Ciccozzi, Massimo
Pascarella, Stefano
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bianchi, Martina
Benvenuto, Domenico
Giovanetti, Marta
Angeletti, Silvia
Ciccozzi, Massimo
Pascarella, Stefano
dc.subject.other.pt_BR.fl_str_mv SARS-CoV-2
Envelope SARS-CoV-2
Proteínas de membrana
Estruturais Diferenças
Características do vírus
COVID-19
topic SARS-CoV-2
Envelope SARS-CoV-2
Proteínas de membrana
Estruturais Diferenças
Características do vírus
COVID-19
SARS-CoV-2
Envelope and Membrane proteins
Structural Differences
Virus Characteristics
COVID-19
dc.subject.en.pt_BR.fl_str_mv SARS-CoV-2
Envelope and Membrane proteins
Structural Differences
Virus Characteristics
COVID-19
description Sapienza University of Rome. Department of Biochemical sciences “A Rossi Fanelli”. Rome, Italy.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-27T20:51:10Z
dc.date.available.fl_str_mv 2020-07-27T20:51:10Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BIANCHI, Martina et al. Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics? Biomed Research International, v. 2020, Article ID 4389089, p. 1-6, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42416
dc.identifier.issn.pt_BR.fl_str_mv 2314-6133
dc.identifier.doi.none.fl_str_mv 10.1155/2020/4389089
dc.identifier.eissn.none.fl_str_mv 2314-6141
identifier_str_mv BIANCHI, Martina et al. Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics? Biomed Research International, v. 2020, Article ID 4389089, p. 1-6, 2020.
2314-6133
10.1155/2020/4389089
2314-6141
url https://www.arca.fiocruz.br/handle/icict/42416
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/42416/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/42416/3/MartaGiovanetti_MartinaBianchi_etal_IOC_2020.pdf.txt
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