Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Ferreira, Ralph Antonio Xavier
Data de Publicação: 2018
Outros Autores: Kubelka, Claire Fernandes, Velarde, Luis Guillermo Coca, Matos, Jorge Paulo Strogoff de, Ferreira, Laura Cunha, Reid, Mariana Mancebo, Setúbal, Sérgio, Oliveira, Solange Artimos de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36733
Resumo: Universidade Federal Fluminense. Faculdade de Medicina. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil.
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spelling Ferreira, Ralph Antonio XavierKubelka, Claire FernandesVelarde, Luis Guillermo CocaMatos, Jorge Paulo Strogoff deFerreira, Laura CunhaReid, Mariana ManceboSetúbal, SérgioOliveira, Solange Artimos de2019-10-29T13:07:16Z2019-10-29T13:07:16Z2018FERREIRA, Ralph Antonio Xavier et al. Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 6, p. 753-760, Nov./Dec. 2018.0037-8682https://www.arca.fiocruz.br/handle/icict/3673310.1590/0037-8682-0036-20181678-9849engSociedade Brasileira de Medicina TropicalDengue graveCriançasFatores preditivosFebre hemorrágica da dengueSevere dengueDengue hemorrhagic feverPredictive factorsChildrenPredictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Faculdade de Medicina. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Matemática e Estatística. Disciplina de Estatística. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Disciplina de Nefrologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil.Introduction: Dengue is one of the most important mosquito-borne infections. Severe cases are more frequently observed in adults. However, in 2008, the State of Rio de Janeiro, Brazil, experienced a severe dengue epidemic that primarily affected children and caused many cases of dengue hemorrhagic fever (DHF) and death. Methods: A cross-sectional analytical study was conducted to examine laboratory diagnosis and clinical epidemiologic factors for confirmed dengue cases in patients aged less than 16 years, from January to June 2008, at a municipal hospital in the City of Rio de Janeiro, Brazil. Variables associated with severe outcomes and P values less than .05 were evaluated by means of a logistic regression model. Results: Of the 419 dengue cases studied, 296 were classified as DHF and 123 as classical dengue. Six patients who had DHF died. In multivariate analysis, some laboratory and clinical variables were independently associated with DHF: age 5 years or older (odds ratio [OR], 4.94; 95% confidence interval [CI], 1.30–18.71), abdominal pain (OR, 8.59; 95% CI, 3.17–23.27), hepatomegaly (OR, 15.87; 95% CI, 5.38–46.85), and positive tourniquet test (OR, 10.84; 95% CI, 3.96–29.71). Hypoalbuminemia occurred more frequently than hemoconcentration in DHF cases, and high aminotransferase levels were associated with severity. Conclusions: Age greater than 5 years, abdominal pain, painful hepatomegaly, and positive tourniquet test were predictors of DHF. The high frequency of hepatic impairment suggests that acetaminophen should be avoided in severe cases of dengue.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36733/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClaireKubelka_etal_IOC_2018.pdfClaireKubelka_etal_IOC_2018.pdfapplication/pdf1699473https://www.arca.fiocruz.br/bitstream/icict/36733/2/ClaireKubelka_etal_IOC_2018.pdf68117c7ce6e81c4466b5673489e12148MD52TEXTClaireKubelka_etal_IOC_2018.pdf.txtClaireKubelka_etal_IOC_2018.pdf.txtExtracted texttext/plain30775https://www.arca.fiocruz.br/bitstream/icict/36733/3/ClaireKubelka_etal_IOC_2018.pdf.txt11c4928791b7c7b72f1a9b35d1e01f8eMD53icict/367332019-12-15 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dc.title.pt_BR.fl_str_mv Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil
title Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil
spellingShingle Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil
Ferreira, Ralph Antonio Xavier
Dengue grave
Crianças
Fatores preditivos
Febre hemorrágica da dengue
Severe dengue
Dengue hemorrhagic fever
Predictive factors
Children
title_short Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil
title_full Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil
title_fullStr Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil
title_full_unstemmed Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil
title_sort Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil
author Ferreira, Ralph Antonio Xavier
author_facet Ferreira, Ralph Antonio Xavier
Kubelka, Claire Fernandes
Velarde, Luis Guillermo Coca
Matos, Jorge Paulo Strogoff de
Ferreira, Laura Cunha
Reid, Mariana Mancebo
Setúbal, Sérgio
Oliveira, Solange Artimos de
author_role author
author2 Kubelka, Claire Fernandes
Velarde, Luis Guillermo Coca
Matos, Jorge Paulo Strogoff de
Ferreira, Laura Cunha
Reid, Mariana Mancebo
Setúbal, Sérgio
Oliveira, Solange Artimos de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Ralph Antonio Xavier
Kubelka, Claire Fernandes
Velarde, Luis Guillermo Coca
Matos, Jorge Paulo Strogoff de
Ferreira, Laura Cunha
Reid, Mariana Mancebo
Setúbal, Sérgio
Oliveira, Solange Artimos de
dc.subject.other.pt_BR.fl_str_mv Dengue grave
Crianças
Fatores preditivos
Febre hemorrágica da dengue
topic Dengue grave
Crianças
Fatores preditivos
Febre hemorrágica da dengue
Severe dengue
Dengue hemorrhagic fever
Predictive factors
Children
dc.subject.en.pt_BR.fl_str_mv Severe dengue
Dengue hemorrhagic fever
Predictive factors
Children
description Universidade Federal Fluminense. Faculdade de Medicina. Disciplina de Doenças Infecciosas e Parasitárias. Niterói, RJ, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-10-29T13:07:16Z
dc.date.available.fl_str_mv 2019-10-29T13:07:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, Ralph Antonio Xavier et al. Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 6, p. 753-760, Nov./Dec. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36733
dc.identifier.issn.pt_BR.fl_str_mv 0037-8682
dc.identifier.doi.none.fl_str_mv 10.1590/0037-8682-0036-2018
dc.identifier.eissn.none.fl_str_mv 1678-9849
identifier_str_mv FERREIRA, Ralph Antonio Xavier et al. Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 6, p. 753-760, Nov./Dec. 2018.
0037-8682
10.1590/0037-8682-0036-2018
1678-9849
url https://www.arca.fiocruz.br/handle/icict/36733
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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