Cytokine Levels in Neural Pain in Leprosy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45920 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Neurologia. Rio de Janeiro, RJ, Brasil. |
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Angst, Débora Bartzen MoraesPinheiro, Roberta OlmoVieira, Joyce Soares da SilvaCobas, Roberta ArnoldiHacker, Mariana de Andréa Vilas-BoasPitta, Izabela Jardim RodriguesGiesel, Louise MaraSarno, Euzenir NunesJardim, Márcia Rodrigues2021-02-02T13:35:28Z2021-02-02T13:35:28Z2020ANGST, Débora Bartzen Moraes et al. Cytokine levels in neural pain in Leprosy. Frontiers in Immunology, v. 11, Article 23, 9p, Jan. 2020.1664-3224https://www.arca.fiocruz.br/handle/icict/4592010.3389/fimmu.2020.00023engFrontiers MediaHanseníaseDor nociceptivaNeuropathic painCitocinasDiabetesNeuropathyLeprosyNociceptive painNeuropathic painCytokinesDiabetesNeuropathyCytokine Levels in Neural Pain in Leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Neurologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Endocrinologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasiFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Neurologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Neurologia. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Neurologia. Rio de Janeiro, RJ, Brasil.Pain is a frequent symptom in leprosy patients. It may be predominantly nociceptive, as in neuritis, or neuropathic, due to injury or nerve dysfunction. The differential diagnosis of these two forms of pain is a challenge in clinical practice, especially because it is quite common for a patient to suffer from both types of pain. A better understanding of cytokine profile may serve as a tool in assessing patients and also help to comprehend pathophysiology of leprosy pain. Patients with leprosy and neural pain (n = 22), neuropathic pain (n = 18), neuritis (nociceptive pain) (n = 4), or no pain (n = 17), further to those with diabetic neuropathy and neuropathic pain (n = 17) were recruited at Souza Araujo Out-Patient Unit (Fiocruz, Rio de Janeiro, RJ, Brazil). Serum levels of IL1b, IL-6, IL-10, IL-17, TNF, CCL-2/MCP-1, IFN-g, CXCL-10/IP-10, and TGF-b were evaluated in the different Groups. Impairment in thermal or pain sensitivity was the most frequent clinical finding (95.5%) in leprosy neuropathy patients with and without pain, but less frequent in Diabetic Group (88.2%). Previous reactional episodes have occurred in patients in the leprosy and Pain Group (p = 0.027) more often. Analysis of cytokine levels have demonstrated that the concentrations of IL-1b, TNF, TGF-b, and IL-17 in serum samples of patients having leprosy neuropathy in combination with neuropathic or nociceptive pain were higher when compared to the samples of leprosy neuropathy patients without pain. In addition, these cytokine levels were significantly augmented in leprosy patients with neuropathic pain in relation to those with neuropathic pain due to diabetes. IL-1b levels are an independent variable associated with both types of pain in patients with leprosy neuropathy. IL-6 concentration was increased in both groups with pain. Moreover, CCL-2/MCP-1 and CXCL-10/IP-10 levels were higher in patients with diabetic neuropathy over those with leprosy neuropathy. In brief, IL-1b is an independent variable related to neuropathic and nociceptive pain in patients with leprosy, and could be an important biomarker for patient follow-up. IL-6 was higher in both groups with pain (leprosy and diabetic patients), and could be a therapeutic target in pain control.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45920/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDeborabMOraes_Angst_etal_IOC_2020.pdfDeborabMOraes_Angst_etal_IOC_2020.pdfapplication/pdf627289https://www.arca.fiocruz.br/bitstream/icict/45920/2/DeborabMOraes_Angst_etal_IOC_2020.pdff5deb6f0f43621a644ae758608ad10d1MD52TEXTDeborabMOraes_Angst_etal_IOC_2020.pdf.txtDeborabMOraes_Angst_etal_IOC_2020.pdf.txtExtracted texttext/plain51444https://www.arca.fiocruz.br/bitstream/icict/45920/3/DeborabMOraes_Angst_etal_IOC_2020.pdf.txt7639fe6ed3da5af78c69c3fda79a9212MD53icict/459202021-02-03 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| dc.title.pt_BR.fl_str_mv |
Cytokine Levels in Neural Pain in Leprosy |
| title |
Cytokine Levels in Neural Pain in Leprosy |
| spellingShingle |
Cytokine Levels in Neural Pain in Leprosy Angst, Débora Bartzen Moraes Hanseníase Dor nociceptiva Neuropathic pain Citocinas Diabetes Neuropathy Leprosy Nociceptive pain Neuropathic pain Cytokines Diabetes Neuropathy |
| title_short |
Cytokine Levels in Neural Pain in Leprosy |
| title_full |
Cytokine Levels in Neural Pain in Leprosy |
| title_fullStr |
Cytokine Levels in Neural Pain in Leprosy |
| title_full_unstemmed |
Cytokine Levels in Neural Pain in Leprosy |
| title_sort |
Cytokine Levels in Neural Pain in Leprosy |
| author |
Angst, Débora Bartzen Moraes |
| author_facet |
Angst, Débora Bartzen Moraes Pinheiro, Roberta Olmo Vieira, Joyce Soares da Silva Cobas, Roberta Arnoldi Hacker, Mariana de Andréa Vilas-Boas Pitta, Izabela Jardim Rodrigues Giesel, Louise Mara Sarno, Euzenir Nunes Jardim, Márcia Rodrigues |
| author_role |
author |
| author2 |
Pinheiro, Roberta Olmo Vieira, Joyce Soares da Silva Cobas, Roberta Arnoldi Hacker, Mariana de Andréa Vilas-Boas Pitta, Izabela Jardim Rodrigues Giesel, Louise Mara Sarno, Euzenir Nunes Jardim, Márcia Rodrigues |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Angst, Débora Bartzen Moraes Pinheiro, Roberta Olmo Vieira, Joyce Soares da Silva Cobas, Roberta Arnoldi Hacker, Mariana de Andréa Vilas-Boas Pitta, Izabela Jardim Rodrigues Giesel, Louise Mara Sarno, Euzenir Nunes Jardim, Márcia Rodrigues |
| dc.subject.other.pt_BR.fl_str_mv |
Hanseníase Dor nociceptiva Neuropathic pain Citocinas Diabetes Neuropathy |
| topic |
Hanseníase Dor nociceptiva Neuropathic pain Citocinas Diabetes Neuropathy Leprosy Nociceptive pain Neuropathic pain Cytokines Diabetes Neuropathy |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy Nociceptive pain Neuropathic pain Cytokines Diabetes Neuropathy |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Neurologia. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020 |
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2021-02-02T13:35:28Z |
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2021-02-02T13:35:28Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ANGST, Débora Bartzen Moraes et al. Cytokine levels in neural pain in Leprosy. Frontiers in Immunology, v. 11, Article 23, 9p, Jan. 2020. |
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https://www.arca.fiocruz.br/handle/icict/45920 |
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1664-3224 |
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10.3389/fimmu.2020.00023 |
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ANGST, Débora Bartzen Moraes et al. Cytokine levels in neural pain in Leprosy. Frontiers in Immunology, v. 11, Article 23, 9p, Jan. 2020. 1664-3224 10.3389/fimmu.2020.00023 |
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