The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role

Detalhes bibliográficos
Autor(a) principal: Nihei, Jorge
Data de Publicação: 2021
Outros Autores: Cardillo, Fabiola, Mengel, Jose
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50219
Resumo: CNPq, FAPESB, FAPERJ, FIOCRUZ and FOG (Fundação Octácilio Gualberto).
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spelling Nihei, JorgeCardillo, FabiolaMengel, Jose2021-12-09T11:33:30Z2021-12-09T11:33:30Z2021NIHEI, Jorge; CARDILLO, Fabíola; MENGEL, Jose. The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role. Frontiers in Cellular and Infection Microbiology, 2021.2235-2988https://www.arca.fiocruz.br/handle/icict/5021910.3389/fcimb.2021.758273CNPq, FAPESB, FAPERJ, FIOCRUZ and FOG (Fundação Octácilio Gualberto).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Recôncavo da Bahia. Center of Health Sciences. Santo Antonio de Jesus, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Institute, Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / University Faculties Arthur Sa Earp Neto. Petropolis Medical School. Petropolis, RJ, Brazil.Trypanosoma cruzi infection causes Chagas’ disease in humans. The infection activates the innate and adaptative immunity in an orchestrated immune response to control parasite growth, guaranteeing host survival. Despite an effective immune response to the parasite in the acute phase, the infection progresses to a chronic stage. The parasite infects different tissues such as peripheral neurons, the brain, skeletal muscle, and heart muscle, among many others. It is evident now that tissue-specific immune responses may develop along with anti-parasite immunity. Therefore, mechanisms to regulate immunity and to ensure tissue-specific tolerance are operating during the infection. Studying those immunoregulatory mechanisms is fundamental to improve host protection or control inflammatory reactions that may lead to pathology. The role of IL-2 during T. cruzi infection is not established. IL-2 production by T cells is strongly down-modulated early in the disease by unknown mechanisms and remains low during the chronic phase of the disease. IL-2 activates NK cells, CD4, and CD8 T cells and may be necessary to immunity development. Also, the expansion and maintenance of regulatory T cells require IL-2. Thus, IL-2 may be a key cytokine involved in promoting or down-regulating immune responses, probably in a dose-dependent manner. This study blocked IL-2 during the acute T. cruzi infection by using a neutralizing monoclonal antibody. The results show that parasitemia and mortality rate was lower in animals treated with anti-IL-2. The percentages and total numbers of CD4+CD25+Foxp3+ T cells diminished within three weeks of infection. The numbers of splenic activated/memory CD4 and CD8 splenic T cells increased during the acute infection. T cells producing IFN-g, TNF-a and IL-10 also augmented in anti-IL-2-treated infected mice. The IL-2 blockade also increased the numbers of inflammatory cells in the heart and skeletal muscles and the amount of IL-17 produced by heart T cells. These results suggest that IL-2 might be involved in the immune regulatory response during the acute T. cruzi infection, dampening T cell activation through the expansion/maintenance of regulatory T cells and regulating IL-17 production. Therefore, the IL-2 pathway is an attractive target for therapeutic purposes in acute and chronic phases of Chagas’ disease.engFrontiers MediaDoença de ChagasTrypanosoma cruziLinfócitos T ReguladoresInterleucina-2Interleucina-10Interleucina-17MiocarditeChagas’ diseaseTrypanosoma cruziregulatory T cellsanti-IL-2interleukin-2interleukin-10interleukin-17myocarditisThe Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Roleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50219/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALNihei, Jorge The blockade....pdfNihei, Jorge The 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dc.title.pt_BR.fl_str_mv The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role
title The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role
spellingShingle The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role
Nihei, Jorge
Doença de Chagas
Trypanosoma cruzi
Linfócitos T Reguladores
Interleucina-2
Interleucina-10
Interleucina-17
Miocardite
Chagas’ disease
Trypanosoma cruzi
regulatory T cells
anti-IL-2
interleukin-2
interleukin-10
interleukin-17
myocarditis
title_short The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role
title_full The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role
title_fullStr The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role
title_full_unstemmed The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role
title_sort The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role
author Nihei, Jorge
author_facet Nihei, Jorge
Cardillo, Fabiola
Mengel, Jose
author_role author
author2 Cardillo, Fabiola
Mengel, Jose
author2_role author
author
dc.contributor.author.fl_str_mv Nihei, Jorge
Cardillo, Fabiola
Mengel, Jose
dc.subject.other.pt_BR.fl_str_mv Doença de Chagas
Trypanosoma cruzi
Linfócitos T Reguladores
Interleucina-2
Interleucina-10
Interleucina-17
Miocardite
topic Doença de Chagas
Trypanosoma cruzi
Linfócitos T Reguladores
Interleucina-2
Interleucina-10
Interleucina-17
Miocardite
Chagas’ disease
Trypanosoma cruzi
regulatory T cells
anti-IL-2
interleukin-2
interleukin-10
interleukin-17
myocarditis
dc.subject.en.pt_BR.fl_str_mv Chagas’ disease
Trypanosoma cruzi
regulatory T cells
anti-IL-2
interleukin-2
interleukin-10
interleukin-17
myocarditis
description CNPq, FAPESB, FAPERJ, FIOCRUZ and FOG (Fundação Octácilio Gualberto).
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-09T11:33:30Z
dc.date.available.fl_str_mv 2021-12-09T11:33:30Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NIHEI, Jorge; CARDILLO, Fabíola; MENGEL, Jose. The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role. Frontiers in Cellular and Infection Microbiology, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50219
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2021.758273
identifier_str_mv NIHEI, Jorge; CARDILLO, Fabíola; MENGEL, Jose. The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role. Frontiers in Cellular and Infection Microbiology, 2021.
2235-2988
10.3389/fcimb.2021.758273
url https://www.arca.fiocruz.br/handle/icict/50219
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50219/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50219/2/Nihei%2c%20Jorge%20The%20blockade....pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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