Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil

Detalhes bibliográficos
Autor(a) principal: Costa, Giselle Calasans de Souza
Data de Publicação: 2014
Outros Autores: Jesus, Jaqueline Goes, Rego, Filipe Ferreira de Almeida, Santos, Edson de Souza, Castro Filho, Bernardo Galvão, Gonçalves, Marilda de Souza, Alcantara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7589
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, Brasil
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spelling Costa, Giselle Calasans de SouzaJesus, Jaqueline GoesRego, Filipe Ferreira de AlmeidaSantos, Edson de SouzaCastro Filho, Bernardo GalvãoGonçalves, Marilda de SouzaAlcantara, Luiz Carlos Júnior2014-05-06T19:39:54Z2014-05-06T19:39:54Z2014COSTA, G. C. S. et al. Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil. Memórias do Instituto Oswaldo Cruz, v. 109, n. 2, p. 250-255, 2014.0074-027610.1590/0074-0276140337https://www.arca.fiocruz.br/handle/icict/7589engFiocruzGenetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilStudies on human genetic variations are a useful source of knowledge about human immunodeficiency virus (HIV)-1 infection. The Langerin protein, found at the surface of Langerhans cells, has an important protective role in HIV-1 infection. Differences in Langerin function due to host genetic factors could influence susceptibility to HIV-1 infection. To verify the frequency of mutations in the Langerin gene, 118 samples from HIV-1-infected women and 99 samples from HIV-1-uninfected individuals were selected for sequencing of the promoter and carbohydrate recognition domain (CRD)-encoding regions of the Langerin gene. Langerin promoter analysis revealed two single nucleotide polymorphisms (SNPs) and one mutation in both studied groups, which created new binding sites for certain transcription factors, such as NFAT5, HOXB9.01 and STAT6.01, according to MatInspector software analysis. Three SNPs were observed in the CRD-encoding region in HIV-1-infected and uninfected individuals: p.K313I, c.941C>T and c.983C>T. This study shows that mutations in the Langerin gene are present in the analysed populations at different genotypic and allelic frequencies. Further studies should be conducted to verify the role of these mutations in HIV-1 susceptibility.HIV-1LangerinPolymorphisminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCosta GCS Genetic....pdfCosta GCS Genetic....pdfapplication/pdf618489https://www.arca.fiocruz.br/bitstream/icict/7589/1/Costa%20GCS%20Genetic....pdf31ae65b05f41e9de63b20c8028d2486dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7589/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCosta GCS Genetic....pdf.txtCosta GCS Genetic....pdf.txtExtracted texttext/plain31337https://www.arca.fiocruz.br/bitstream/icict/7589/5/Costa%20GCS%20Genetic....pdf.txta9320aafb4a9b826a8628982545c0c70MD55THUMBNAILCosta GCS Genetic....pdf.jpgCosta GCS Genetic....pdf.jpgGenerated Thumbnailimage/jpeg2213https://www.arca.fiocruz.br/bitstream/icict/7589/4/Costa%20GCS%20Genetic....pdf.jpg0705d86f93922f4010ea3bfa8159bc2bMD54icict/75892023-03-15 14:33:08.014oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:08Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
title Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
spellingShingle Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
Costa, Giselle Calasans de Souza
HIV-1
Langerin
Polymorphism
title_short Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
title_full Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
title_fullStr Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
title_full_unstemmed Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
title_sort Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil
author Costa, Giselle Calasans de Souza
author_facet Costa, Giselle Calasans de Souza
Jesus, Jaqueline Goes
Rego, Filipe Ferreira de Almeida
Santos, Edson de Souza
Castro Filho, Bernardo Galvão
Gonçalves, Marilda de Souza
Alcantara, Luiz Carlos Júnior
author_role author
author2 Jesus, Jaqueline Goes
Rego, Filipe Ferreira de Almeida
Santos, Edson de Souza
Castro Filho, Bernardo Galvão
Gonçalves, Marilda de Souza
Alcantara, Luiz Carlos Júnior
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Giselle Calasans de Souza
Jesus, Jaqueline Goes
Rego, Filipe Ferreira de Almeida
Santos, Edson de Souza
Castro Filho, Bernardo Galvão
Gonçalves, Marilda de Souza
Alcantara, Luiz Carlos Júnior
dc.subject.en.pt_BR.fl_str_mv HIV-1
Langerin
Polymorphism
topic HIV-1
Langerin
Polymorphism
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, Brasil
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-05-06T19:39:54Z
dc.date.available.fl_str_mv 2014-05-06T19:39:54Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, G. C. S. et al. Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil. Memórias do Instituto Oswaldo Cruz, v. 109, n. 2, p. 250-255, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7589
dc.identifier.issn.none.fl_str_mv 0074-0276
10.1590/0074-0276140337
identifier_str_mv COSTA, G. C. S. et al. Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil. Memórias do Instituto Oswaldo Cruz, v. 109, n. 2, p. 250-255, 2014.
0074-0276
10.1590/0074-0276140337
url https://www.arca.fiocruz.br/handle/icict/7589
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Fiocruz
publisher.none.fl_str_mv Fiocruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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