Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries

Schwartz, David A.; Avvad-Portari, Elyzabeth; Babál, Pavel; Baldewijns, Marcella; Blomberg, Marie; Bouachba, Amine; Camacho, Jessica; Collardeau-Frachon, Sophie; Colson, Arthur; Dehaene, Isabelle; Ferreres, Joan Carles; Fitzgerald, Brendan; Garrido-Pontnou, Marta; Gergis, Hazem; Hargitai, Beata; Helguera-Repetto, A. Cecilia; Holmström, Sandra; Irles, Claudine Liliane; Leijonhfvud, Åsa; Libbrecht, Sasha; Marton, Tamás; McEntagart, Noel; Molina, James T.; Morotti, Raffaella; Nadal, Alfons; Navarro, Alexandra; Nelander, Maria; Oviedo, Angelica; Otani, Andre Ricardo Oyamada; Papadogiannakis, Nikos; Petersen, Astrid C.; Roberts, Drucilla J.; Saad, Ali G.; Sand, Anna; Schoenmakers, Sam; Sehn, Jennifer K.; Simpson, Preston R.; Thomas, Kristen; Valdespino-Vázquez, M. Yolotzin; Van Der Meeren, Lotte E.; Van Dorpe, Jo; Verdijk, Robert M.; Watkins, Jaclyn C.; Zaigham, Mehreen

Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries

Detalhes bibliográficos
Autor(a) principal:	Schwartz, David A.
Data de Publicação:	2022
Outros Autores:	Avvad-Portari, Elyzabeth, Babál, Pavel, Baldewijns, Marcella, Blomberg, Marie, Bouachba, Amine, Camacho, Jessica, Collardeau-Frachon, Sophie, Colson, Arthur, Dehaene, Isabelle, Ferreres, Joan Carles, Fitzgerald, Brendan, Garrido-Pontnou, Marta, Gergis, Hazem, Hargitai, Beata, Helguera-Repetto, A. Cecilia, Holmström, Sandra, Irles, Claudine Liliane, Leijonhfvud, Åsa, Libbrecht, Sasha, Marton, Tamás, McEntagart, Noel, Molina, James T., Morotti, Raffaella, Nadal, Alfons, Navarro, Alexandra, Nelander, Maria, Oviedo, Angelica, Otani, Andre Ricardo Oyamada, Papadogiannakis, Nikos, Petersen, Astrid C., Roberts, Drucilla J., Saad, Ali G., Sand, Anna, Schoenmakers, Sam, Sehn, Jennifer K., Simpson, Preston R., Thomas, Kristen, Valdespino-Vázquez, M. Yolotzin, Van Der Meeren, Lotte E., Van Dorpe, Jo, Verdijk, Robert M., Watkins, Jaclyn C., Zaigham, Mehreen
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/55029
Resumo:	Sem afiliação.

Metadados do item

id	CRUZ_feea51d19710785809dd844e402076b7
oai_identifier_str	oai:www.arca.fiocruz.br:icict/55029
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Schwartz, David A.Avvad-Portari, ElyzabethBabál, PavelBaldewijns, MarcellaBlomberg, MarieBouachba, AmineCamacho, JessicaCollardeau-Frachon, SophieColson, ArthurDehaene, IsabelleFerreres, Joan CarlesFitzgerald, BrendanGarrido-Pontnou, MartaGergis, HazemHargitai, BeataHelguera-Repetto, A. CeciliaHolmström, SandraIrles, Claudine LilianeLeijonhfvud, ÅsaLibbrecht, SashaMarton, TamásMcEntagart, NoelMolina, James T.Morotti, RaffaellaNadal, AlfonsNavarro, AlexandraNelander, MariaOviedo, AngelicaOtani, Andre Ricardo OyamadaPapadogiannakis, NikosPetersen, Astrid C.Roberts, Drucilla J.Saad, Ali G.Sand, AnnaSchoenmakers, SamSehn, Jennifer K.Simpson, Preston R.Thomas, KristenValdespino-Vázquez, M. YolotzinVan Der Meeren, Lotte E.Van Dorpe, JoVerdijk, Robert M.Watkins, Jaclyn C.Zaigham, Mehreen2022-10-06T17:44:37Z2022-10-06T17:44:37Z2022SCHWARTZ, David A. et al. Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries. Archives of Pathology & Laboratory Medicine, v. 146, n. 6, p. 660-676, June 2022.0003-9985https://www.arca.fiocruz.br/handle/icict/5502910.5858/arpa.2022-0029-SA1543-2165engCollege of American PathologistsPlacental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countriesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSem afiliação.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Comenius University. Faculty of Medicine. Department of Pathology. Bratislava, Slovakia.University Hospitals Leuven. Department of Pathology. Leuven, Belgium.Linköping University. Department of Obstetrics and Gynecology. Linköping, Sweden / Linköping University. Department of Biomedical and Clinical Sciences. Linköping, Sweden.Hospices Civils de Lyon. Institut de Pathologie Multisite. Lyon, France / SOFFOET–Société Française de Fœtopathologie, Paris, France.Hospital Universitari Vall d'Hebron. Pathology Department. Barcelona, Spain.SOFFOET–Société Française de Fœtopathologie, Paris, France / Université Claude Bernard Lyon 1. Hospices Civils de Lyon. Hopital Femme-Mère Enfant. Department of Pathology. Bron, France.Université Catholique de Louvain. Institute of Experimental and Clinical Research. Department of Obstetrics. Brussels, Belgium.Ghent University Hospital. Department of Obstetrics and Gynaecology. Ghent, Belgium.Institut d'Investigació i Innovació Parc Taulí I3PT. Parc Taulí Hospital Universitari. Pathology Department. Barcelona, Spain / Universitat Autònoma de Barcelona. School of Medicine. Department of Morphological Sciences. Sabadell, Spain.Cork University Hospital. Department of Pathology. Wilton, Cork, Republic of Ireland.Hospital Universitari Vall d'Hebron. Pathology Department. Barcelona, Spain / Universitat Autònoma de Barcelona. School of Medicine. Department of Morphological Sciences. Barcelona, Spain.Women's Hospital. Doncaster and Bassetlaw NHS Teaching Hospitals. Department of Obstetrics and Gynaecology. Doncaster, United Kingdom.NHS Foundation Trust. Birmingham Women's and Children's Hospital. Department of Cellular Pathology. Division of Perinatal Pathology. Birmingham, United Kingdom.National Institute of Perinatology. Department of Immunobiochemistry. Mexico City, Mexico.Halland Hospital. Department of Obstetrics and Gynaecology. Varberg, Sweden.National Institute of Perinatology “Isidro Espinosa de los Reyes”. Department of Physiology and Cellular Development. Mexico City, Mexico.Helsingborg Hospital. Department of Obstetrics and Gynaecology. Helsingborg, Sweden / Lund University. Department of Clinical Science Helsingborg. Lund, Sweden.Antwerp University Hospital. Department of Pathological Anatomy. Edegem, Belgium.Birmingham Women's Hospital. Cellular Pathology Department. Birmingham, United Kingdom.Rotunda Hospital. Histopathology. Dublin, Republic of Ireland.Sem afiliação.Yale University School of Medicine. Autopsy Service. Department of Pathology and Pediatrics. New Haven, Connecticut.Hospital Clínic. Pathology Department. Barcelona, Spain / Universitat de Barcelona. School of Medicine. Department of Basic Clinical Practice. Barcelona, Spain / August Pi i Sunyer Biomedical Research Institute. Barcelona, Spain.Hospital Universitari Vall d'Hebron. Pathology Department. Barcelona, Spain.Uppsala University. Department of Women's and Children's Health. Uppsala, Sweden.Burrell College of Osteopathic Medicine. Department of Pathology and Laboratory Medicine. Las Cruces, New Mexico.Laboratório Ferdinando Costa. São Paulo, SP, Brasil.Karolinska University Hospital. Division of Pathology. Department of Laboratory Medicine. Stockholm, Sweden / Karolinska University Hospital. Departments of Pathology. Stockholm, Sweden.Aalborg University Hospital. Department of Pathology. Aalborg, Denmark.Harvard Medical School. Massachusetts General Hospital. Department of Pathology. Boston, Massachusetts.University of Miami Miller School of Medicine/Jackson Health System/Holtz Children's Hospital. Department of Pathology. Pediatric Pathology and Neuropathology. Miami, Florida.Karolinska Institute. Department of Women's and Children's Health. Stockholm, Sweden / Karolinska University Hospital. Department of Obstetrics and Gynaecology. Solna, Stockholm, Sweden.University Medical Center Rotterdam. Department of Obstetrics and Gynaecology. Rotterdam, the Netherlands.St. Louis University School of Medicine. Department of Pathology. St Louis, Missouri.CHRISTUS Hospital St Elizabeth. Department of Pathology. Beaumont, Texas.New York University School of Medicine. NYU Langone Health–Main Campus & Bellevue Hospital Center. Department of Pathology. New York, USA.National Institute of Perinatology. Department of Anatomical Pathology. Mexico City, Mexico.Leiden University Medical Center. Department of Pathology. Leiden, the Netherlands / University Medical Center Utrecht. Department of Pathology. Utrecht, the Netherlands.Ghent University Hospital. Department of Pathology. Ghent, Belgium.University Medical Center Rotterdam. Department of Obstetrics and Gynaecology. Rotterdam, the Netherlands.Harvard Medical School. Massachusetts General Hospital. Department of Pathology. Boston, Massachusetts.Lund University. Institution of Clinical Sciences Lund. Obstetrics & Gynecology. Lund, Sweden / Skåne University Hospital. Department of Obstetrics and Gynecology. Malmö and Lund, Sweden.Context.—Perinatal death is an increasingly important problem as the coronavirus disease 2019 (COVID-19) pandemic continues, but the mechanism of death has been unclear. Objective.—To evaluate the role of the placenta in causing stillbirth and neonatal death following maternal infection with COVID-19 and confirmed placental positivity for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Design.—Case-based retrospective clinicopathologic analysis by a multinational group of 44 perinatal specialists from 12 countries of placental and autopsy pathology findings from 64 stillborns and 4 neonatal deaths having placentas testing positive for SARS-CoV-2 following delivery to mothers with COVID-19. Results.—Of the 3 findings constituting SARS-CoV-2 placentitis, all 68 placentas had increased fibrin deposition and villous trophoblast necrosis and 66 had chronic histiocytic intervillositis. Sixty-three placentas had massive perivillous fibrin deposition. Severe destructive placental disease from SARS-CoV-2 placentitis averaged 77.7% tissue involvement. Other findings included multiple intervillous thrombi (37%; 25 of 68) and chronic villitis (32%; 22 of 68). The majority (19; 63%) of the 30 autopsies revealed no significant fetal abnormalities except for intrauterine hypoxia and asphyxia. Among all 68 cases, SARS-CoV-2 was detected from a body specimen in 16 of 28 cases tested, most frequently from nasopharyngeal swabs. Four autopsied stillborns had SARS-CoV-2 identified in internal organs. Conclusions.—The pathology abnormalities composing SARS-CoV-2 placentitis cause widespread and severe placental destruction resulting in placental malperfusion and insufficiency. In these cases, intrauterine and perinatal death likely results directly from placental insufficiency and fetal hypoxic-ischemic injury. There was no evidence that SARS-CoV-2 involvement of the fetus had a role in causing these deaths.SARS-CoV-2 placentitisPerinatal deathCOVID-19SARS-CoV-2info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55029/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPlacental Tissue Destruction and Insufficiency From COVID-19 Causes Stillbirth and Neonatal Death From Hypoxic-Ischemic Injury.pdfPlacental Tissue Destruction and Insufficiency From COVID-19 Causes Stillbirth and Neonatal Death From Hypoxic-Ischemic Injury.pdfapplication/pdf1208549https://www.arca.fiocruz.br/bitstream/icict/55029/2/Placental%20Tissue%20Destruction%20and%20Insufficiency%20From%20COVID-19%20Causes%20Stillbirth%20and%20Neonatal%20Death%20From%20Hypoxic-Ischemic%20Injury.pdfb2a33674c6337b6b7ff1857bae592d6fMD52icict/550292022-10-06 14:44:38.47oai:www.arca.fiocruz.br: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ório 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dc.title.en_US.fl_str_mv	Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries
title	Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries
spellingShingle	Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries Schwartz, David A. SARS-CoV-2 placentitis Perinatal death COVID-19 SARS-CoV-2
title_short	Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries
title_full	Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries
title_fullStr	Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries
title_full_unstemmed	Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries
title_sort	Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries
author	Schwartz, David A.
author_facet	Schwartz, David A. Avvad-Portari, Elyzabeth Babál, Pavel Baldewijns, Marcella Blomberg, Marie Bouachba, Amine Camacho, Jessica Collardeau-Frachon, Sophie Colson, Arthur Dehaene, Isabelle Ferreres, Joan Carles Fitzgerald, Brendan Garrido-Pontnou, Marta Gergis, Hazem Hargitai, Beata Helguera-Repetto, A. Cecilia Holmström, Sandra Irles, Claudine Liliane Leijonhfvud, Åsa Libbrecht, Sasha Marton, Tamás McEntagart, Noel Molina, James T. Morotti, Raffaella Nadal, Alfons Navarro, Alexandra Nelander, Maria Oviedo, Angelica Otani, Andre Ricardo Oyamada Papadogiannakis, Nikos Petersen, Astrid C. Roberts, Drucilla J. Saad, Ali G. Sand, Anna Schoenmakers, Sam Sehn, Jennifer K. Simpson, Preston R. Thomas, Kristen Valdespino-Vázquez, M. Yolotzin Van Der Meeren, Lotte E. Van Dorpe, Jo Verdijk, Robert M. Watkins, Jaclyn C. Zaigham, Mehreen
author_role	author
author2	Avvad-Portari, Elyzabeth Babál, Pavel Baldewijns, Marcella Blomberg, Marie Bouachba, Amine Camacho, Jessica Collardeau-Frachon, Sophie Colson, Arthur Dehaene, Isabelle Ferreres, Joan Carles Fitzgerald, Brendan Garrido-Pontnou, Marta Gergis, Hazem Hargitai, Beata Helguera-Repetto, A. Cecilia Holmström, Sandra Irles, Claudine Liliane Leijonhfvud, Åsa Libbrecht, Sasha Marton, Tamás McEntagart, Noel Molina, James T. Morotti, Raffaella Nadal, Alfons Navarro, Alexandra Nelander, Maria Oviedo, Angelica Otani, Andre Ricardo Oyamada Papadogiannakis, Nikos Petersen, Astrid C. Roberts, Drucilla J. Saad, Ali G. Sand, Anna Schoenmakers, Sam Sehn, Jennifer K. Simpson, Preston R. Thomas, Kristen Valdespino-Vázquez, M. Yolotzin Van Der Meeren, Lotte E. Van Dorpe, Jo Verdijk, Robert M. Watkins, Jaclyn C. Zaigham, Mehreen
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Schwartz, David A. Avvad-Portari, Elyzabeth Babál, Pavel Baldewijns, Marcella Blomberg, Marie Bouachba, Amine Camacho, Jessica Collardeau-Frachon, Sophie Colson, Arthur Dehaene, Isabelle Ferreres, Joan Carles Fitzgerald, Brendan Garrido-Pontnou, Marta Gergis, Hazem Hargitai, Beata Helguera-Repetto, A. Cecilia Holmström, Sandra Irles, Claudine Liliane Leijonhfvud, Åsa Libbrecht, Sasha Marton, Tamás McEntagart, Noel Molina, James T. Morotti, Raffaella Nadal, Alfons Navarro, Alexandra Nelander, Maria Oviedo, Angelica Otani, Andre Ricardo Oyamada Papadogiannakis, Nikos Petersen, Astrid C. Roberts, Drucilla J. Saad, Ali G. Sand, Anna Schoenmakers, Sam Sehn, Jennifer K. Simpson, Preston R. Thomas, Kristen Valdespino-Vázquez, M. Yolotzin Van Der Meeren, Lotte E. Van Dorpe, Jo Verdijk, Robert M. Watkins, Jaclyn C. Zaigham, Mehreen
dc.subject.en.en_US.fl_str_mv	SARS-CoV-2 placentitis Perinatal death COVID-19 SARS-CoV-2
topic	SARS-CoV-2 placentitis Perinatal death COVID-19 SARS-CoV-2
description	Sem afiliação.
publishDate	2022
dc.date.accessioned.fl_str_mv	2022-10-06T17:44:37Z
dc.date.available.fl_str_mv	2022-10-06T17:44:37Z
dc.date.issued.fl_str_mv	2022
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	SCHWARTZ, David A. et al. Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries. Archives of Pathology & Laboratory Medicine, v. 146, n. 6, p. 660-676, June 2022.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/55029
dc.identifier.issn.en_US.fl_str_mv	0003-9985
dc.identifier.doi.none.fl_str_mv	10.5858/arpa.2022-0029-SA
dc.identifier.eissn.none.fl_str_mv	1543-2165
identifier_str_mv	SCHWARTZ, David A. et al. Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries. Archives of Pathology & Laboratory Medicine, v. 146, n. 6, p. 660-676, June 2022. 0003-9985 10.5858/arpa.2022-0029-SA 1543-2165
url	https://www.arca.fiocruz.br/handle/icict/55029
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	College of American Pathologists
publisher.none.fl_str_mv	College of American Pathologists
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/55029/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/55029/2/Placental%20Tissue%20Destruction%20and%20Insufficiency%20From%20COVID-19%20Causes%20Stillbirth%20and%20Neonatal%20Death%20From%20Hypoxic-Ischemic%20Injury.pdf
bitstream.checksum.fl_str_mv	5a560609d32a3863062d77ff32785d58 b2a33674c6337b6b7ff1857bae592d6f
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury: a study of 68 cases with SARS-CoV-2 placentitis from 12 countries

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