Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort

Detalhes bibliográficos
Autor(a) principal: Martins, Jéssica S. C.
Data de Publicação: 2020
Outros Autores: Oliveira, Maria L. A., Garcia, Cristiana C., Siqueira, Marilda Agudo Mendonça Teixeira de, Matos, Aline R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42206
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.
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spelling Martins, Jéssica S. C.Oliveira, Maria L. A.Garcia, Cristiana C.Siqueira, Marilda Agudo Mendonça Teixeira deMatos, Aline R.2020-07-10T19:27:43Z2020-07-10T19:27:43Z2020MARTINS, Jéssica S. C. et al. Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort. Frontiers in Cellular and Infection Microbiology, v. 10, Article 352, 10p, July 2020.2235-2988https://www.arca.fiocruz.br/handle/icict/4220610.3389/fcimb.2020.00352engFrontiers MediaVírus da InfluenzaBiomarcadorIFITM3PolimorfismoSuscetibilidadeInfluenza virusesBiomarkerIFITM3PolymorphismSusceptibilityInvestigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohortinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Influenza is a major public health problem that causes acute respiratory infection in humans. Identification of host factors influencing in disease outcome is critical for recognition of individuals with increased risk. Investigations on the role of rs34481144A and rs12252C IFITM3 polymorphisms in influenza A(H1N1)pdm09 severity is not yet conclusively determined. This study aimed to evaluate such polymorphisms frequencies and IFITM3 levels in an infected Brazilian cohort of 314 influenza A(H1N1)pdm09 cases and its putative association with clinical, epidemiological and virological data. Individuals were clinically classified into mild, severe and fatal cases. IFITM3 polymorphisms were detected by specific Taqman probes in real time PCR reactions. IFITM3 levels were determined by quantitative real time PCR. Thus, the different clinical groups presented similar distribution of rs34481144 and rs12252 genotypes and allelic frequencies. There was no significant association between the polymorphisms with severity of disease by using distinct genetic models. Additionally, geographic distribution of mutants showed that rs34481144A allele was more predominant in Brazilian Southern region. In contrast, rs12252C allele presented similar frequencies in all regions. Individuals with the distinct rs34481144 and rs12252 genotypes showed similar levels of IFITM3 and viral load in their respiratory specimens. Furthermore, IFITM3 levels were comparable in the distinct clinical groups and were not correlated with influenza viral load in analyzed samples. Thereby, rs34481144A and rs12252C polymorphisms were not associated with severity or mortality of influenza A(H1N1)pdm09 infection nor with IFITM3 transcript levels and influenza viral load in upper respiratory tract samples in a Brazilian cohort.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42206/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarildaSiqueria_AlineMatos_etal_IOC_2020.pdfMarildaSiqueria_AlineMatos_etal_IOC_2020.pdfapplication/pdf528069https://www.arca.fiocruz.br/bitstream/icict/42206/2/MarildaSiqueria_AlineMatos_etal_IOC_2020.pdf9b9c296242886ba901a6542e92cc9ae0MD52TEXTMarildaSiqueria_AlineMatos_etal_IOC_2020.pdf.txtMarildaSiqueria_AlineMatos_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort
title Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort
spellingShingle Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort
Martins, Jéssica S. C.
Vírus da Influenza
Biomarcador
IFITM3
Polimorfismo
Suscetibilidade
Influenza viruses
Biomarker
IFITM3
Polymorphism
Susceptibility
title_short Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort
title_full Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort
title_fullStr Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort
title_full_unstemmed Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort
title_sort Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort
author Martins, Jéssica S. C.
author_facet Martins, Jéssica S. C.
Oliveira, Maria L. A.
Garcia, Cristiana C.
Siqueira, Marilda Agudo Mendonça Teixeira de
Matos, Aline R.
author_role author
author2 Oliveira, Maria L. A.
Garcia, Cristiana C.
Siqueira, Marilda Agudo Mendonça Teixeira de
Matos, Aline R.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Martins, Jéssica S. C.
Oliveira, Maria L. A.
Garcia, Cristiana C.
Siqueira, Marilda Agudo Mendonça Teixeira de
Matos, Aline R.
dc.subject.other.pt_BR.fl_str_mv Vírus da Influenza
Biomarcador
IFITM3
Polimorfismo
Suscetibilidade
topic Vírus da Influenza
Biomarcador
IFITM3
Polimorfismo
Suscetibilidade
Influenza viruses
Biomarker
IFITM3
Polymorphism
Susceptibility
dc.subject.en.pt_BR.fl_str_mv Influenza viruses
Biomarker
IFITM3
Polymorphism
Susceptibility
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-10T19:27:43Z
dc.date.available.fl_str_mv 2020-07-10T19:27:43Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARTINS, Jéssica S. C. et al. Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort. Frontiers in Cellular and Infection Microbiology, v. 10, Article 352, 10p, July 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42206
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2020.00352
identifier_str_mv MARTINS, Jéssica S. C. et al. Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort. Frontiers in Cellular and Infection Microbiology, v. 10, Article 352, 10p, July 2020.
2235-2988
10.3389/fcimb.2020.00352
url https://www.arca.fiocruz.br/handle/icict/42206
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/42206/1/license.txt
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