Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice

Detalhes bibliográficos
Autor(a) principal: Silva, Michele Costa
Data de Publicação: 2002
Outros Autores: Silva, Rosângela Rodrigues e, Hulstijn, Maarten, Neves, Renata Heisler, Panasco, Monica de Souza, Lenzi, Henrique Leonel, Silva, José Roberto Machado e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/4059
Resumo: Apresentado em: International Symposium on Schistosomiasis, 8, Recife, Dec. 2-5, 2001.
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spelling Silva, Michele CostaSilva, Rosângela Rodrigues eHulstijn, MaartenNeves, Renata HeislerPanasco, Monica de SouzaLenzi, Henrique LeonelSilva, José Roberto Machado e2012-05-10T17:38:56Z2012-05-10T17:38:56Z2002COSTA-SILVA, M. et al.Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.97, sup. 1, p.129-142, 2002.0074-0276https://www.arca.fiocruz.br/handle/icict/4059Apresentado em: International Symposium on Schistosomiasis, 8, Recife, Dec. 2-5, 2001.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Patologia e Laboratórios, Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, BrasilUniversidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Patologia e Laboratórios, Rio de Janeiro, RJ, BrasilUniversidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Patologia e Laboratórios, Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Patologia e Laboratórios, Rio de Janeiro, RJ, BrasilHistopathologic and morphometric (area, perimeter, major and minor diameters) analysis of hepatic granulomas isolated from twelve naturally infected Nectomys squamipes were compared to four experimentally infected ones and six C3H/He mice. Liver paraffin sections were stained for cells and extracellular matrix. Both groups of N. squamipes presented peculiar granulomas consisting predominantly of large macrophages, full of schistosome pigment, characterizing an exudative-macrophage granuloma type, smaller than the equivalent granuloma type in mouse. Naturally infected animals exhibited granulomas in different stages of development, including large number of involutional types. Morphometric analysis showed that all measurements were smaller in naturally infected animals than in other groups. The results demonstrated that both N. squamipes groups reproduced, with small variations, the hepatic granuloma aspects already described in cricetidium (Calomys callosus), showing a genetic tendency to set up strong macrophage responses and small granulomas. Unexpectedly, natural infection did not engender distinguished histopathological characteristics distinct from those derived from experimental single infection, showing changes predominantly secondary to the duration of infection. It appears that the variability of the inocula (and the number of infections?) interfere more with the quantity than with the quality of the pathological changes, denoting some morpho-functional determinism in the response to schistosomal infection dependent on the animal species.engFundação Oswaldo Cruz. Instituto Oswaldo CruzNatural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSchistosoma mansoniNectomys squamipesC3H/He miceHepatic granulomaHistopathologyMorphometryDoenças dos Roedores, patologiaEsquistossomose mansoni, veterináriaCamundongos Endogâmicos C3H, pasitologiaEsquistossomose mansoni, parasitologiaHepatopatias Parasitárias, parasitologiaFígado, parasitologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALNatural Schistosoma mansoni Infection.pdfNatural Schistosoma mansoni Infection.pdfapplication/pdf740601https://www.arca.fiocruz.br/bitstream/icict/4059/1/Natural%20Schistosoma%20mansoni%20Infection.pdfdedd1d0275ed5f0d1227c1605c024da4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/4059/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTNatural Schistosoma mansoni Infection.pdf.txtNatural Schistosoma mansoni Infection.pdf.txtExtracted texttext/plain43290https://www.arca.fiocruz.br/bitstream/icict/4059/5/Natural%20Schistosoma%20mansoni%20Infection.pdf.txt673937942e642b77749d461844949a4cMD55THUMBNAILNatural Schistosoma mansoni Infection.pdf.jpgNatural Schistosoma mansoni Infection.pdf.jpgGenerated Thumbnailimage/jpeg2508https://www.arca.fiocruz.br/bitstream/icict/4059/4/Natural%20Schistosoma%20mansoni%20Infection.pdf.jpg12539eafb0134d45e3bd908d5d0de197MD54icict/40592018-04-06 08:58:03.394oai:www.arca.fiocruz.br:icict/4059Tk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKQnkgc2lnbmluZyBhbmQgc3VibWl0dGluZyB0aGlzIGxpY2Vuc2UsIHlvdSAodGhlIGF1dGhvcihzKSBvciBjb3B5cmlnaHQKb3duZXIpIGdyYW50cyB0byBEU3BhY2UgVW5pdmVyc2l0eSAoRFNVKSB0aGUgbm9uLWV4Y2x1c2l2ZSByaWdodCB0byByZXByb2R1Y2UsCnRyYW5zbGF0ZSAoYXMgZGVmaW5lZCBiZWxvdyksIGFuZC9vciBkaXN0cmlidXRlIHlvdXIgc3VibWlzc2lvbiAoaW5jbHVkaW5nCnRoZSBhYnN0cmFjdCkgd29ybGR3aWRlIGluIHByaW50IGFuZCBlbGVjdHJvbmljIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bSwKaW5jbHVkaW5nIGJ1dCBub3QgbGltaXRlZCB0byBhdWRpbyBvciB2aWRlby4KCllvdSBhZ3JlZSB0aGF0IERTVSBtYXksIHdpdGhvdXQgY2hhbmdpbmcgdGhlIGNvbnRlbnQsIHRyYW5zbGF0ZSB0aGUKc3VibWlzc2lvbiB0byBhbnkgbWVkaXVtIG9yIGZvcm1hdCBmb3IgdGhlIHB1cnBvc2Ugb2YgcHJlc2VydmF0aW9uLgoKWW91IGFsc28gYWdyZWUgdGhhdCBEU1UgbWF5IGtlZXAgbW9yZSB0aGFuIG9uZSBjb3B5IG9mIHRoaXMgc3VibWlzc2lvbiBmb3IKcHVycG9zZXMgb2Ygc2VjdXJpdHksIGJhY2stdXAgYW5kIHByZXNlcnZhdGlvbi4KCllvdSByZXByZXNlbnQgdGhhdCB0aGUgc3VibWlzc2lvbiBpcyB5b3VyIG9yaWdpbmFsIHdvcmssIGFuZCB0aGF0IHlvdSBoYXZlCnRoZSByaWdodCB0byBncmFudCB0aGUgcmlnaHRzIGNvbnRhaW5lZCBpbiB0aGlzIGxpY2Vuc2UuIFlvdSBhbHNvIHJlcHJlc2VudAp0aGF0IHlvdXIgc3VibWlzc2lvbiBkb2VzIG5vdCwgdG8gdGhlIGJlc3Qgb2YgeW91ciBrbm93bGVkZ2UsIGluZnJpbmdlIHVwb24KYW55b25lJ3MgY29weXJpZ2h0LgoKSWYgdGhlIHN1Ym1pc3Npb24gY29udGFpbnMgbWF0ZXJpYWwgZm9yIHdoaWNoIHlvdSBkbyBub3QgaG9sZCBjb3B5cmlnaHQsCnlvdSByZXByZXNlbnQgdGhhdCB5b3UgaGF2ZSBvYnRhaW5lZCB0aGUgdW5yZXN0cmljdGVkIHBlcm1pc3Npb24gb2YgdGhlCmNvcHlyaWdodCBvd25lciB0byBncmFudCBEU1UgdGhlIHJpZ2h0cyByZXF1aXJlZCBieSB0aGlzIGxpY2Vuc2UsIGFuZCB0aGF0CnN1Y2ggdGhpcmQtcGFydHkgb3duZWQgbWF0ZXJpYWwgaXMgY2xlYXJseSBpZGVudGlmaWVkIGFuZCBhY2tub3dsZWRnZWQKd2l0aGluIHRoZSB0ZXh0IG9yIGNvbnRlbnQgb2YgdGhlIHN1Ym1pc3Npb24uCgpJRiBUSEUgU1VCTUlTU0lPTiBJUyBCQVNFRCBVUE9OIFdPUksgVEhBVCBIQVMgQkVFTiBTUE9OU09SRUQgT1IgU1VQUE9SVEVECkJZIEFOIEFHRU5DWSBPUiBPUkdBTklaQVRJT04gT1RIRVIgVEhBTiBEU1UsIFlPVSBSRVBSRVNFTlQgVEhBVCBZT1UgSEFWRQpGVUxGSUxMRUQgQU5ZIFJJR0hUIE9GIFJFVklFVyBPUiBPVEhFUiBPQkxJR0FUSU9OUyBSRVFVSVJFRCBCWSBTVUNICkNPTlRSQUNUIE9SIEFHUkVFTUVOVC4KCkRTVSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgeW91ciBuYW1lKHMpIGFzIHRoZSBhdXRob3Iocykgb3Igb3duZXIocykgb2YgdGhlCnN1Ym1pc3Npb24sIGFuZCB3aWxsIG5vdCBtYWtlIGFueSBhbHRlcmF0aW9uLCBvdGhlciB0aGFuIGFzIGFsbG93ZWQgYnkgdGhpcwpsaWNlbnNlLCB0byB5b3VyIHN1Ym1pc3Npb24uCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:58:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice
title Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice
spellingShingle Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice
Silva, Michele Costa
Schistosoma mansoni
Nectomys squamipes
C3H/He mice
Hepatic granuloma
Histopathology
Morphometry
Doenças dos Roedores, patologia
Esquistossomose mansoni, veterinária
Camundongos Endogâmicos C3H, pasitologia
Esquistossomose mansoni, parasitologia
Hepatopatias Parasitárias, parasitologia
Fígado, parasitologia
title_short Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice
title_full Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice
title_fullStr Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice
title_full_unstemmed Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice
title_sort Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice
author Silva, Michele Costa
author_facet Silva, Michele Costa
Silva, Rosângela Rodrigues e
Hulstijn, Maarten
Neves, Renata Heisler
Panasco, Monica de Souza
Lenzi, Henrique Leonel
Silva, José Roberto Machado e
author_role author
author2 Silva, Rosângela Rodrigues e
Hulstijn, Maarten
Neves, Renata Heisler
Panasco, Monica de Souza
Lenzi, Henrique Leonel
Silva, José Roberto Machado e
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Michele Costa
Silva, Rosângela Rodrigues e
Hulstijn, Maarten
Neves, Renata Heisler
Panasco, Monica de Souza
Lenzi, Henrique Leonel
Silva, José Roberto Machado e
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
Nectomys squamipes
C3H/He mice
Hepatic granuloma
Histopathology
Morphometry
topic Schistosoma mansoni
Nectomys squamipes
C3H/He mice
Hepatic granuloma
Histopathology
Morphometry
Doenças dos Roedores, patologia
Esquistossomose mansoni, veterinária
Camundongos Endogâmicos C3H, pasitologia
Esquistossomose mansoni, parasitologia
Hepatopatias Parasitárias, parasitologia
Fígado, parasitologia
dc.subject.decs.pt_BR.fl_str_mv Doenças dos Roedores, patologia
Esquistossomose mansoni, veterinária
Camundongos Endogâmicos C3H, pasitologia
Esquistossomose mansoni, parasitologia
Hepatopatias Parasitárias, parasitologia
Fígado, parasitologia
description Apresentado em: International Symposium on Schistosomiasis, 8, Recife, Dec. 2-5, 2001.
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2012-05-10T17:38:56Z
dc.date.available.fl_str_mv 2012-05-10T17:38:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA-SILVA, M. et al.Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.97, sup. 1, p.129-142, 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/4059
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv COSTA-SILVA, M. et al.Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.97, sup. 1, p.129-142, 2002.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/4059
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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