Household rat infestation in urban slum populations: development and validation of a predictive score for leptospirosis

Detalhes bibliográficos
Autor(a) principal: Costa, Federico
Data de Publicação: 2021
Outros Autores: Zeppelini, Caio Graco, Ribeiro, Guilherme de Sousa, Santos, Norlan, Reis, Renato Barbosa, Martins, Ridalva D., Bittencourt, Deborah, Santana, Carlos, Brant, Jonas, Reis, Mitermayer Galvão dos, Ko, Albert Icksang
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46505
Resumo: National Institutes of Health (grants R01 AI052473, U01 AI088752, R01 TW009504, R24 TW007988, R25 TW009338 and D43 TW00919). FC has been granted funds by the Wellcome trust for the study [102330/Z/13/Z; 218987/Z/19/Z] and a CAPES doctorate scholarship (Coordination for the Improvement of Higher Education Personnel/ Ministry of Education/ Brazil; https://www.gov.br/capes/pt-br), CGZ has received a doctorate scholarship from FAPESB (Foundation for Research Assistance of Bahia, http://www.fapesb.ba.gov.br/). GSR received a research scholarship from the Brazilian National Research Council (CNPq – www.cnpq.br). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
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spelling Costa, FedericoZeppelini, Caio GracoRibeiro, Guilherme de SousaSantos, NorlanReis, Renato BarbosaMartins, Ridalva D.Bittencourt, DeborahSantana, CarlosBrant, JonasReis, Mitermayer Galvão dosKo, Albert Icksang2021-04-05T13:57:06Z2021-04-05T13:57:06Z2021COSTA, Federico et al. Household rat infestation in urban slum populations: Development and validation of a predictive score for leptospirosis. PLOS Neglected Tropical Diseases, p. 1-13, Mar. 3, 2021.1935-2735https://www.arca.fiocruz.br/handle/icict/4650510.1371/journal.pntd.000915410.1371/journal.pntd.0009154National Institutes of Health (grants R01 AI052473, U01 AI088752, R01 TW009504, R24 TW007988, R25 TW009338 and D43 TW00919). FC has been granted funds by the Wellcome trust for the study [102330/Z/13/Z; 218987/Z/19/Z] and a CAPES doctorate scholarship (Coordination for the Improvement of Higher Education Personnel/ Ministry of Education/ Brazil; https://www.gov.br/capes/pt-br), CGZ has received a doctorate scholarship from FAPESB (Foundation for Research Assistance of Bahia, http://www.fapesb.ba.gov.br/). GSR received a research scholarship from the Brazilian National Research Council (CNPq – www.cnpq.br). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Ecologia: Teoria, Aplicação e Valores. Salvador, BA, Brasil.Universidade Federal da Bahia. Programa de Pós-Graduação em Ecologia: Teoria, Aplicação e Valores. Salvador, BA, Brasil / Universidade Federal da Paraíba. Laboratório de Mamíferos. João Pessoa, PB, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Ministério da Saúde. Centro de Controle de Zoonoses. Salvador, BA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Programa de Treinamento em Epidemiologia Aplicada aos Serviços do SUS. Brasıília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale University, New Heaven. Yale School of Public Health. USA.Domestic rats are the principal reservoir for urban leptospirosis. However, few studies have identified infestation markers in slums and evaluated their predictivity for leptospirosis risk. We compared households with leptospirosis cases in Salvador, Brazil between 2007 and 2009 and their neighbors using a case control design, surveying for rodent infestation signs and environmental characteristics. With the 2007–2008 data, a conditional logistic regression modeling identified the peridomiciliar presence of rodent burrows (OR, 3.30; 95% CI, 1.50–7.26), rat feces (2.86; 1.24–6.59), runs (2.57; 1.06–6.22), households bordering abandoned houses (2.48; 1.04–6.02), and unplastered walls (2.22; 1.02–6.02) as risk factors and developed a predictive score for leptospirosis. With an independent data set from 2009, a receiver operating characteristic (ROC) curve analysis evaluated the prediction score performance, with the area under the curve being 0.70 (95% CI, 0.64–0.76) for score development and 0.71 (0.65–0.79) for validation. Results indicate that high proportions of urban slum households are infested with R. norvegicus. The score performed well when identifying high-risk households within slums. These findings need confirmation in other urban centers, but suggest that community-based screening for rodent infestation can allow to target rodent and environmental control measures in populations at highest risk for leptospirosis.engPublic Library of ScienceLeptospirosePopulaçãoÁreas de PobrezaFatores de riscoCaracterísticas da FamíliaBrasilLeptospirosisPopulationPoverty AreasRisks factorsFamily CharacteristicsBrazilHousehold rat infestation in urban slum populations: development and validation of a predictive score for leptospirosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46505/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALCosta, Federico Household....pdfCosta, Federico 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dc.title.pt_BR.fl_str_mv Household rat infestation in urban slum populations: development and validation of a predictive score for leptospirosis
title Household rat infestation in urban slum populations: development and validation of a predictive score for leptospirosis
spellingShingle Household rat infestation in urban slum populations: development and validation of a predictive score for leptospirosis
Costa, Federico
Leptospirose
População
Áreas de Pobreza
Fatores de risco
Características da Família
Brasil
Leptospirosis
Population
Poverty Areas
Risks factors
Family Characteristics
Brazil
title_short Household rat infestation in urban slum populations: development and validation of a predictive score for leptospirosis
title_full Household rat infestation in urban slum populations: development and validation of a predictive score for leptospirosis
title_fullStr Household rat infestation in urban slum populations: development and validation of a predictive score for leptospirosis
title_full_unstemmed Household rat infestation in urban slum populations: development and validation of a predictive score for leptospirosis
title_sort Household rat infestation in urban slum populations: development and validation of a predictive score for leptospirosis
author Costa, Federico
author_facet Costa, Federico
Zeppelini, Caio Graco
Ribeiro, Guilherme de Sousa
Santos, Norlan
Reis, Renato Barbosa
Martins, Ridalva D.
Bittencourt, Deborah
Santana, Carlos
Brant, Jonas
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
author_role author
author2 Zeppelini, Caio Graco
Ribeiro, Guilherme de Sousa
Santos, Norlan
Reis, Renato Barbosa
Martins, Ridalva D.
Bittencourt, Deborah
Santana, Carlos
Brant, Jonas
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Federico
Zeppelini, Caio Graco
Ribeiro, Guilherme de Sousa
Santos, Norlan
Reis, Renato Barbosa
Martins, Ridalva D.
Bittencourt, Deborah
Santana, Carlos
Brant, Jonas
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
dc.subject.other.pt_BR.fl_str_mv Leptospirose
População
Áreas de Pobreza
Fatores de risco
Características da Família
Brasil
topic Leptospirose
População
Áreas de Pobreza
Fatores de risco
Características da Família
Brasil
Leptospirosis
Population
Poverty Areas
Risks factors
Family Characteristics
Brazil
dc.subject.en.pt_BR.fl_str_mv Leptospirosis
Population
Poverty Areas
Risks factors
Family Characteristics
Brazil
description National Institutes of Health (grants R01 AI052473, U01 AI088752, R01 TW009504, R24 TW007988, R25 TW009338 and D43 TW00919). FC has been granted funds by the Wellcome trust for the study [102330/Z/13/Z; 218987/Z/19/Z] and a CAPES doctorate scholarship (Coordination for the Improvement of Higher Education Personnel/ Ministry of Education/ Brazil; https://www.gov.br/capes/pt-br), CGZ has received a doctorate scholarship from FAPESB (Foundation for Research Assistance of Bahia, http://www.fapesb.ba.gov.br/). GSR received a research scholarship from the Brazilian National Research Council (CNPq – www.cnpq.br). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-05T13:57:06Z
dc.date.available.fl_str_mv 2021-04-05T13:57:06Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv COSTA, Federico et al. Household rat infestation in urban slum populations: Development and validation of a predictive score for leptospirosis. PLOS Neglected Tropical Diseases, p. 1-13, Mar. 3, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46505
dc.identifier.issn.pt_BR.fl_str_mv 1935-2735
dc.identifier.doi.pt_BR.fl_str_mv 10.1371/journal.pntd.0009154
dc.identifier.eissn.none.fl_str_mv 10.1371/journal.pntd.0009154
identifier_str_mv COSTA, Federico et al. Household rat infestation in urban slum populations: Development and validation of a predictive score for leptospirosis. PLOS Neglected Tropical Diseases, p. 1-13, Mar. 3, 2021.
1935-2735
10.1371/journal.pntd.0009154
url https://www.arca.fiocruz.br/handle/icict/46505
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Public Library of Science
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