Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal?
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/60257 |
Resumo: | This research was funded by PAEF-IOC 008-F10–22-2-49 APQ1 e-26/211-707/2021. J Leite-Silva is a student from the Biologia Parasitária Program (Oswaldo Cruz Institute-Fiocruz) with a scholarship from VPEIC/Fiocruz. A. Schubach is a fellow of VPEIC/Fiocruz and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). F. Morgado received productivity fellowships from CNPq (CNPq–308785/2021-5) and Programa Jovem Cientista do Nosso Estado FAPERJ (FAPERJ–E-26/202.760/2019). |
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Leite-Silva, JéssicaOliveira-Ribeiro, CarlaMorgado, Fernanda NazaréPimentel, Maria Inês FernandesLyra, Marcelo RosandiskiFagundes, AlineMiranda, Luciana Freitas CamposValete-Rosalino, Claudia MariaSchubach, Armando OliveiraConceição-Silva, Fátima2023-08-30T00:56:09Z2023-08-30T00:56:09Z2023LEITE-SILVA, Jéssica et al. Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal? Microorganisms, v. 11, n. 7, p. 1-21, June 2023.2076-2607https://www.arca.fiocruz.br/handle/icict/6025710.3390/microorganisms110716312076-2607This research was funded by PAEF-IOC 008-F10–22-2-49 APQ1 e-26/211-707/2021. J Leite-Silva is a student from the Biologia Parasitária Program (Oswaldo Cruz Institute-Fiocruz) with a scholarship from VPEIC/Fiocruz. A. Schubach is a fellow of VPEIC/Fiocruz and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). F. Morgado received productivity fellowships from CNPq (CNPq–308785/2021-5) and Programa Jovem Cientista do Nosso Estado FAPERJ (FAPERJ–E-26/202.760/2019).Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Immunoparasitology. Rio de Janeiro, RJ, Brazil.National Institute of Cancer. Service of Oncological Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Immunoparasitology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research and Surveillance in Leishmaniasis. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research and Surveillance in Leishmaniasis. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research and Surveillance in Leishmaniasis. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research and Surveillance in Leishmaniasis. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research and Surveillance in Leishmaniasis. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research and Surveillance in Leishmaniasis. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Immunoparasitology. Rio de Janeiro, RJ, Brazil.Localized cutaneous leishmaniasis caused by Leishmania braziliensis can either respond well or poorly to the treatment or heal spontaneously; It seems to be dependent on the parasite and/or host factors, but the mechanisms are not fully understood. We evaluated the in situ immune response in eighty-two active lesions from fifty-eight patients prior to treatment classified as early spontaneous regression (SRL-n = 14); treatment responders (GRL-n = 20); and non-responders (before first treatment/relapse, PRL1/PRL2-n = 24 each). Immunohistochemistry was used to identify cell/functional markers which were correlated with the clinical characteristics. PRL showed significant differences in lesion number/size, clinical evolution, and positive parasitological examinations when compared with the other groups. SRL presented a more efficient immune response than GRL and PRL, with higher IFN-γ/NOS2 and a lower percentage of macrophages, neutrophils, NK, B cells, and Ki-67+ cells. Compared to SRL, PRL had fewer CD4+ Tcells and more CD163+ macrophages. PRL1 had more CD68+ macrophages and Ki-67+ cells but less IFN-γ than GRL. PRL present a less efficient immune profile, which could explain the poor treatment response, while SRL had a more balanced immune response profile for lesion healing. Altogether, these evaluations suggest a differentiated profile of the organization of the inflammatory process for lesions of different tegumentary leishmaniasis evolution.engMDPIIs There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCD163Cell-mediated immunityCutaneous leishmaniasisHost-parasite interactionImmunohistochemistryImmunopathologyIn situ immune responseMacrophagesSpontaneous healingTreatment relapseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.en_US.fl_str_mv |
Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal? |
| title |
Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal? |
| spellingShingle |
Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal? Leite-Silva, Jéssica CD163 Cell-mediated immunity Cutaneous leishmaniasis Host-parasite interaction Immunohistochemistry Immunopathology In situ immune response Macrophages Spontaneous healing Treatment relapse |
| title_short |
Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal? |
| title_full |
Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal? |
| title_fullStr |
Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal? |
| title_full_unstemmed |
Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal? |
| title_sort |
Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal? |
| author |
Leite-Silva, Jéssica |
| author_facet |
Leite-Silva, Jéssica Oliveira-Ribeiro, Carla Morgado, Fernanda Nazaré Pimentel, Maria Inês Fernandes Lyra, Marcelo Rosandiski Fagundes, Aline Miranda, Luciana Freitas Campos Valete-Rosalino, Claudia Maria Schubach, Armando Oliveira Conceição-Silva, Fátima |
| author_role |
author |
| author2 |
Oliveira-Ribeiro, Carla Morgado, Fernanda Nazaré Pimentel, Maria Inês Fernandes Lyra, Marcelo Rosandiski Fagundes, Aline Miranda, Luciana Freitas Campos Valete-Rosalino, Claudia Maria Schubach, Armando Oliveira Conceição-Silva, Fátima |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Leite-Silva, Jéssica Oliveira-Ribeiro, Carla Morgado, Fernanda Nazaré Pimentel, Maria Inês Fernandes Lyra, Marcelo Rosandiski Fagundes, Aline Miranda, Luciana Freitas Campos Valete-Rosalino, Claudia Maria Schubach, Armando Oliveira Conceição-Silva, Fátima |
| dc.subject.en.en_US.fl_str_mv |
CD163 Cell-mediated immunity Cutaneous leishmaniasis Host-parasite interaction Immunohistochemistry Immunopathology In situ immune response Macrophages Spontaneous healing Treatment relapse |
| topic |
CD163 Cell-mediated immunity Cutaneous leishmaniasis Host-parasite interaction Immunohistochemistry Immunopathology In situ immune response Macrophages Spontaneous healing Treatment relapse |
| description |
This research was funded by PAEF-IOC 008-F10–22-2-49 APQ1 e-26/211-707/2021. J Leite-Silva is a student from the Biologia Parasitária Program (Oswaldo Cruz Institute-Fiocruz) with a scholarship from VPEIC/Fiocruz. A. Schubach is a fellow of VPEIC/Fiocruz and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). F. Morgado received productivity fellowships from CNPq (CNPq–308785/2021-5) and Programa Jovem Cientista do Nosso Estado FAPERJ (FAPERJ–E-26/202.760/2019). |
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2023 |
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2023-08-30T00:56:09Z |
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2023-08-30T00:56:09Z |
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2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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LEITE-SILVA, Jéssica et al. Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal? Microorganisms, v. 11, n. 7, p. 1-21, June 2023. |
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https://www.arca.fiocruz.br/handle/icict/60257 |
| dc.identifier.issn.en_US.fl_str_mv |
2076-2607 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/microorganisms11071631 |
| dc.identifier.eissn.none.fl_str_mv |
2076-2607 |
| identifier_str_mv |
LEITE-SILVA, Jéssica et al. Is There Any Difference in the In Situ Immune Response in Active Localized Cutaneous Leishmaniasis That Respond Well or Poorly to Meglumine Antimoniate Treatment or Spontaneously Heal? Microorganisms, v. 11, n. 7, p. 1-21, June 2023. 2076-2607 10.3390/microorganisms11071631 |
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MDPI |
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MDPI |
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