Efeitos da infusão intravenosa contínua e da injeção epidural de cetamina racêmica na dor pós-incisional em cães

• Autor(a) principal: Maia, Andrea Smith
• Data de Publicação: 2010
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório do Centro Universitário Braz Cubas
• Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/690
• topic: Dor; Cetamina; Epidural; Infusão contínua; CNPQ::CIENCIAS AGRARIAS::ZOOTECNIA

Ketamine has been successfully used in pain treatment because of its antagonist action to N-methyl D-aspartate (NMDA). The aim of this work was to study the effects of the antinociceptive of the epidural injection and the continuous infusion of the racemic Ketamine on post-incisional pain, in dogs. For doing so, ten dogs were divided into two groups with 5 dogs in each namely the continuous infusion group (GIC) and the epidural group (GEP). The animals were anesthetized with propofol 5mg/kg, IV in the cephatic vein, which had been catheterized with catheter (22G) followed by continuous infusion in the rate of 0.6mg/kg/min for the insertion of the epidural catheter (18G) in the lombo-sacral space. Subsequently, a surgical incision in the footpad of the right pelvic limb was carried out, being immediately sutured with four simple separated stitches with nylon thread 3-0. Ten minutes afterwards, a racemic ketamine epidural injection was applied in rates of 0.6mg/kg in the GEP group and 0.5 mg/kg IV of racemic ketamine in the cephalic vein for the continuous infusion group, followed by continuous infusion in rates of 0.015mg/kg/min. Cardiac and respiratory frequencies were taken, as well as rectal temperature, blood pressure, sedation degree and claudication. Furthermore, with the application of digital analgesimeter, the mechanical hyperalgesia was measured in four regions: cranial, lateral, medial and caudal on the tail on the incision line. There was a slight reduction of body temperature during the experimental period in both groups. Regarding the answer to the mechanical hyperalgesi, there was a difference in all regions where strength was applied in different moments, observing a decrease in answer as regarding the baseline as well as differences between the groups in different moments, noticing that the GIC group showed lower rates. There were not any meaningful differences as regarding other parameters. It was concluded that both pathway are efficient to the use of racemic ketamine as a painkiller, even though the epidural pathway were more efficient compared to the the continuous infusion.