Efeitos da anestesia epidural sobre a coagulação de cães submetidos a ovariohisterectomia eletiva

• Autor(a) principal: Martins, Paula Carolina
• Data de Publicação: 2020
• Outros Autores: Silva, Alessandra Souza da
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório do Centro Universitário Braz Cubas
• Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/3276
• topic: Anestesia regional; Anestesia epidural; Anestésicos locais; Cascata de coagulação; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA

Epidural anesthesia is a widely used anesthetic technique in veterinary medicine and is used as an alternative to relieve intraoperative and postoperative pain. In humans, decreased thromboembolic complications have been attributed to regional anesthesia because blockade appears to affect the coagulation cascade. In dogs, however, there are few studies demonstrating the effects of epidural anesthesia on these parameters. Thus, the objective of this study was to evaluate the coagulation process of bitches submitted to epidural anesthesia with lidocaine for elective ovariohysterectomy surgery, by means of oral mucosa bleeding time (TSMO), activated partial thromboplastin time (TTPA), prothrombin (PT), platelet count and white blood cell count. A prospective study was conducted with twelve animals randomly divided into three groups: AEL (lidocaine epidural anesthesia); AESF (epidural anesthesia with physiological solution and continuous intravenous infusion of fentanyl citrate - 10 mcg / kg / h); and, AF (fentanyl citrate infusion - 10 mcg / kg / h). The animals were evaluated in four moments: M0 - basal; M1 - 15 minutes after epidural technique or beginning of analgesic infusion; M2 - 60 minutes after epidural technique or beginning of analgesic infusion; and, M3 - 120 minutes after epidural technique or beginning of analgesic infusion. Data were analyzed using GraphPad Prism 7.00 software. To confirm the normality of data distribution, the Shapiro-Wilk test was used. An analysis of variance (ANOVA) was performed to compare means, followed by Tukey's post-hoc for the multiple comparison between means, and Kruskal-Wallis test for nonparametric ones followed by Dunn's post hoc. Correlations were performed with Pearson's correlation test for parametric data and Spearman's correlation test for nonparametric data. The confidence interval adopted was 95% (p <0.05). There was no statistical difference between groups on coagulation parameters. The only data with statistical difference was temperature in M2 (p = 0.01) in M2. The different anesthetic protocols tested showed no significant difference on the coagulation of the evaluated animals