Resultados oncológicos em pacientes submetidas a cirurgia oncoplastica de mama
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório do Centro Universitário Braz Cubas |
Texto Completo: | https://repositorio.cruzeirodosul.edu.br/handle/123456789/2252 |
Resumo: | Background: Oncoplastic surgery (OP) allows bigger resections with mammoplasty techniques preserving the shape and symmetry of the breast. However, there is still the fear that it can make any necessary reoperation more difficult when it results in compromised margins because of tissue displacement. The aim of this study was to analyze the margins status, necessity for reoperation, local recurrence rates, distant metastasis, overall survival (OS) and disease free survival (DFS), in a single institution retrospective/prospective cohort. Methods: 246 patients were included with invasive or in situ breast carcinomas submitted to OP at the Nossa Senhora das Graças Hospital in Curitiba (Brazil), between the years 2004 to 2014. The follow-up began in 2008 and continued until 2016. Patients who had neoadjuvant chemotherapy or unilateral OP were excluded. A P value of less than 0.05 was considered significant Results: The median follow-up was 56 months; the reoperation rate was 6.09% with a 4% rate of mastectomy. The local recurrence rate was 5.2% and the metastasis rate was 4%. The rate of positive margins was 11.6%. Patients N0 and estrogen receptor-positive had a lower risk for local recurrence. Patients with linfovascular invasion showed increased risk for distant metastasis and a need for reoperation. Conclusion: The widespread use of OP is an approach that allows optimal oncologic resection while maintaining satisfactory cosmetic results. This study is of a large series of patients followed over the long term that showed low local recurrence rate, low positive margins and low reoperation rates, with a low mastectomy rate. More prospective randomized trials are needed to prove that OP can lower the reoperation rates in BCS. |
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Resultados oncológicos em pacientes submetidas a cirurgia oncoplastica de mamaBiotecnologiaMamoplastiaMamas - Câncer - CirurgiaCâncer - Cirurgia plásticaCNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERALBackground: Oncoplastic surgery (OP) allows bigger resections with mammoplasty techniques preserving the shape and symmetry of the breast. However, there is still the fear that it can make any necessary reoperation more difficult when it results in compromised margins because of tissue displacement. The aim of this study was to analyze the margins status, necessity for reoperation, local recurrence rates, distant metastasis, overall survival (OS) and disease free survival (DFS), in a single institution retrospective/prospective cohort. Methods: 246 patients were included with invasive or in situ breast carcinomas submitted to OP at the Nossa Senhora das Graças Hospital in Curitiba (Brazil), between the years 2004 to 2014. The follow-up began in 2008 and continued until 2016. Patients who had neoadjuvant chemotherapy or unilateral OP were excluded. A P value of less than 0.05 was considered significant Results: The median follow-up was 56 months; the reoperation rate was 6.09% with a 4% rate of mastectomy. The local recurrence rate was 5.2% and the metastasis rate was 4%. The rate of positive margins was 11.6%. Patients N0 and estrogen receptor-positive had a lower risk for local recurrence. Patients with linfovascular invasion showed increased risk for distant metastasis and a need for reoperation. Conclusion: The widespread use of OP is an approach that allows optimal oncologic resection while maintaining satisfactory cosmetic results. This study is of a large series of patients followed over the long term that showed low local recurrence rate, low positive margins and low reoperation rates, with a low mastectomy rate. More prospective randomized trials are needed to prove that OP can lower the reoperation rates in BCS.INTRODUÇÃO: A cirurgia oncoplástica (OP) permite resseções maiores utilizando técnicas de mamoplastia e assim mantendo a forma e a simetria entre as mamas . Existem poucas séries na literatura com seguimento de longo prazo. O objetivo deste estudo foi analisar o status das margens cirúrgicas, a taxa de reoperação, a taxa de recidiva local, metástase, sobrevida global e sobrevida livre de doença em uma única instituição. MÉTODO: Foram incluídas 246 pacientes com carcinomas invasivos ou in situ, submetidas à OP na Unidade da Mama do Hospital Nossa Senhora das Graças em Curitiba (Brasil), entre os anos de 2004 a 2014, com seguimento até 2016. Foram excluídas pacientes que tiveram quimioterapia neoadjuvante ou OP unilateral. Foi considerado nível de significância estatística de 5% (p=0,05). RESULTADOS: A média de seguimento foi de 56 meses; A taxa de reoperação foi de 6,09% com uma taxa de necessidade de mastectomia de 4%, a taxa de recidiva local foi de 5,2% e a taxa de metástase a distância foi de 4%. A taxa de margens comprometidas foi de 11,6%. Pacientes N0 e receptor de estrogênio positivo tiveram menor risco para recidiva local. Pacientes com infiltração linfovascular presente apresentaram risco aumentado para metástase a distância e necessidade de reoperação. CONCLUSÕES: A OP se popularizou por ser uma abordagem que permite ressecção oncológica ótima e ao mesmo tempo mantendo resultado estético satisfatório. Com este estudo, em uma grande série de pacientes que foram seguidas a longo prazo demonstrou-se baixa taxa de recidiva local e baixas taxas de reoperação e de margens comprometidas. Existe a necessidade de mais estudos prospectivos randomizados para que avaliem o papel da oncoplástica como um fator redutor do número de reoperações e margens comprometidas.Universidade PositivoBrasilPós-GraduaçãoPrograma de Pós-Graduação em Biotecnologia IndustrialUPUrban, Cicero de Andradehttp://lattes.cnpq.br/0718187625853159Dias, Vanessa do Valle Vieira Amoroso2021-05-25T19:08:49Z20172021-05-25T19:08:49Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://repositorio.cruzeirodosul.edu.br/handle/123456789/2252porinfo:eu-repo/semantics/openAccessreponame:Repositório do Centro Universitário Braz Cubasinstname:Centro Universitário Braz Cubas (CUB)instacron:CUB2021-05-28T17:20:46Zoai:repositorio.cruzeirodosul.edu.br:123456789/2252Repositório InstitucionalPUBhttps://repositorio.brazcubas.edu.br/oai/requestbibli@brazcubas.edu.bropendoar:2021-05-28T17:20:46Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)false |
dc.title.none.fl_str_mv |
Resultados oncológicos em pacientes submetidas a cirurgia oncoplastica de mama |
title |
Resultados oncológicos em pacientes submetidas a cirurgia oncoplastica de mama |
spellingShingle |
Resultados oncológicos em pacientes submetidas a cirurgia oncoplastica de mama Dias, Vanessa do Valle Vieira Amoroso Biotecnologia Mamoplastia Mamas - Câncer - Cirurgia Câncer - Cirurgia plástica CNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERAL |
title_short |
Resultados oncológicos em pacientes submetidas a cirurgia oncoplastica de mama |
title_full |
Resultados oncológicos em pacientes submetidas a cirurgia oncoplastica de mama |
title_fullStr |
Resultados oncológicos em pacientes submetidas a cirurgia oncoplastica de mama |
title_full_unstemmed |
Resultados oncológicos em pacientes submetidas a cirurgia oncoplastica de mama |
title_sort |
Resultados oncológicos em pacientes submetidas a cirurgia oncoplastica de mama |
author |
Dias, Vanessa do Valle Vieira Amoroso |
author_facet |
Dias, Vanessa do Valle Vieira Amoroso |
author_role |
author |
dc.contributor.none.fl_str_mv |
Urban, Cicero de Andrade http://lattes.cnpq.br/0718187625853159 |
dc.contributor.author.fl_str_mv |
Dias, Vanessa do Valle Vieira Amoroso |
dc.subject.por.fl_str_mv |
Biotecnologia Mamoplastia Mamas - Câncer - Cirurgia Câncer - Cirurgia plástica CNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERAL |
topic |
Biotecnologia Mamoplastia Mamas - Câncer - Cirurgia Câncer - Cirurgia plástica CNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERAL |
description |
Background: Oncoplastic surgery (OP) allows bigger resections with mammoplasty techniques preserving the shape and symmetry of the breast. However, there is still the fear that it can make any necessary reoperation more difficult when it results in compromised margins because of tissue displacement. The aim of this study was to analyze the margins status, necessity for reoperation, local recurrence rates, distant metastasis, overall survival (OS) and disease free survival (DFS), in a single institution retrospective/prospective cohort. Methods: 246 patients were included with invasive or in situ breast carcinomas submitted to OP at the Nossa Senhora das Graças Hospital in Curitiba (Brazil), between the years 2004 to 2014. The follow-up began in 2008 and continued until 2016. Patients who had neoadjuvant chemotherapy or unilateral OP were excluded. A P value of less than 0.05 was considered significant Results: The median follow-up was 56 months; the reoperation rate was 6.09% with a 4% rate of mastectomy. The local recurrence rate was 5.2% and the metastasis rate was 4%. The rate of positive margins was 11.6%. Patients N0 and estrogen receptor-positive had a lower risk for local recurrence. Patients with linfovascular invasion showed increased risk for distant metastasis and a need for reoperation. Conclusion: The widespread use of OP is an approach that allows optimal oncologic resection while maintaining satisfactory cosmetic results. This study is of a large series of patients followed over the long term that showed low local recurrence rate, low positive margins and low reoperation rates, with a low mastectomy rate. More prospective randomized trials are needed to prove that OP can lower the reoperation rates in BCS. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017 2021-05-25T19:08:49Z 2021-05-25T19:08:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/2252 |
url |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/2252 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Positivo Brasil Pós-Graduação Programa de Pós-Graduação em Biotecnologia Industrial UP |
publisher.none.fl_str_mv |
Universidade Positivo Brasil Pós-Graduação Programa de Pós-Graduação em Biotecnologia Industrial UP |
dc.source.none.fl_str_mv |
reponame:Repositório do Centro Universitário Braz Cubas instname:Centro Universitário Braz Cubas (CUB) instacron:CUB |
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Centro Universitário Braz Cubas (CUB) |
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CUB |
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CUB |
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Repositório do Centro Universitário Braz Cubas |
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Repositório do Centro Universitário Braz Cubas |
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Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB) |
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bibli@brazcubas.edu.br |
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