Principais alterações endócrinas após infecção pelo SARS-CoV-2: Revisão integrativa

• Autor(a) principal: Silva, Letícia Figueirôa
• Data de Publicação: 2022
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório do Centro Universitário Braz Cubas
• Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/4173
• topic: COVID-19; glicose; diabetesmellitus; tireoidite subaguda; CNPQ::CIENCIAS DA SAUDE::MEDICINA

COVID-19 was initially reported as a set of cases of pneumonia of unknown origin, which spread around the world, culminating in the pandemic by the “New” Coronavirus. Although the main target of SARS-CoV-2 is the respiratory tract, it can trigger important extrapulmonary manifestations, including endocrinological ones. The objective of this study is to describe the main endocrine alterations that the patient infected with the SARS-CoV-2 virus may present. This wasan exploratory, descriptive and cross-sectional literature review, of the integrative literature review type, carried out from scientific medical publications indexed in the PubMed electronic database.The selection of articles followed the inclusion and exclusion criteria established and the data collection wasmade through an adaptation of the checklist proposed by PRISMA. The articles were analyzedfollowing the PICO method. The studies that were included in this literature review pointed out that there is a bidirectional relationship between endocrine manifestations and COVID-19, because in addition to some endocrine diseases having the ability to take the patient to a more serious state when infected with the virus, COVID-19 can also make previously healthy individuals begin to manifest endocrine alterations.With regard to pancreatic manifestations, several studies have evaluated hyperglycemia as a marker of severity in patients with COVID-19, in which some have even analyzed this relationship in non-diabetic patients. In addition, a worse prognosis was also seen in patients with newly diagnosed diabetes when compared to those with preexisting diabetes. Recent studies also bring up the possibility of SARS-CoV-2 as a diabetogenic virus. As for thyroid changes subsequent to COVID-19, cases of patients who developed Subacute Thyroiditis (SAT) after being infected with SARS-CoV-2 have been described. A case of a patient who developed Hashimoto's thyroiditis after infection was also reported. In addition, two studies evaluated the serum levels of thyroid hormones, concluding that the lower the TSH and T3L values, the more severe were the patients. Thus, although new information is constantly emerging, many of these manifestations remain not completely elucidated, and further studies in the area are essential in order to contribute to the clinical management of patients who suffer from the changes resulting from this viral infection.