Avaliação radiográfica da periodontite experimental induzida pela porphyromonas gingivalis com e sem ligaduras após tratamento com alendronato e resveratrol

• Autor(a) principal: Gontarz, Driele Maria
• Data de Publicação: 2019
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório do Centro Universitário Braz Cubas
• Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/2106
• topic: Periodontite; Ligaduras; Porphyromonas gingivalis; Radiografia; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA

Periodontitis is a chronic inflammatory disease that develops over time through the accumulation of bacterial biofilm, inducing the exacerbated production of immuneinflammatory mediators. The aim of this study was to radiographically analyze the influence of alendronate and resveratrol on periodontitis induced by Porphyromonas gingivalis (P. gingivalis) with and without ligation. One hundred and twenty rats were submitted to experimental periodontitis through two techniques of induction of the disease: with ligation associated with P. gingivalis (LPg) and without ligation associated with P. gingivalis (SLPg). After the disease was established, the rats were divided into 4 groups according to the treatment: the alendronate group (ALN), which received the dose of 2 mg/kg/day of alendronate; the resveratrol group (RESV) receiving the 10 mg/kg/day dose of resveratrol dissolved in 10 mg/ml soluble starch; β- cyclodextrin (β-CD) /RESV group receiving the 10 mg/kg/day dose of the complex and control group receiving the 10 mg/kg/day β- CD dose. The medications were administered orally by gavage for 30 days. The animals were euthanized and the jaw surgical specimens were x-rayed and submitted to ImageJ ® software for the measurement of bone resorption of proximal regions (cemented enamel junction to alveolar bone crest). Data were submitted to statistical analysis using the Kruskal Wallis and Mann-Whitney tests, with a significance level of 0.05. Rats receiving RESV, β- CD / RESV and placebo received higher bone loss in the presence of ligation (p < 0.05). In the presence of ALN, ligation did not increase bone loss (p > 0.05). In conclusion, we found that the ALN, when compared to itself, in a more acute bone loss, does not seem to accentuate the bone loss