Uso de metformina na diabetes mellitus gestacional: uma revisão bibliográfica

Detalhes bibliográficos
Autor(a) principal: Ferreira Filho, João Rosier
Data de Publicação: 2020
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório do Centro Universitário Braz Cubas
Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/1309
Resumo: Gestational Diabetes Mellitus is a condition of hyperglycemic state during pregnancy, can lead to outcomes that are not favorable to the fetal maternal binomial, has frequent occurrence and a strong tendency to increase its incidence; its study is important to avoid possible complications with potential death. In this scenario, it is pertinent to update through the literature, on safety in the management of an oral antidiabetic to control this pathology. Identify from scientific studies or use of metformin in Gestational Diabetes Mellitus, an end of clarification, no current panorama, your solution for glycemic control in conjunction with safe pregnancy, as well as possible neuropsychomotor effects in the child. This is an exploratory bibliographic review, regarding the use of metformin without control of Gestational Diabetes Mellitus, using as databases: Latin American and Caribbean Literature in Health Sciences (LILACS), Scientific Eletronic Library Online (SCIELO ) and National Library of Medicine (PUBMED). A strong tendency was then identified to support the use of metformin in DMG, since, in the literature, no impediment was found to its management during pregnancy, there were positive results regarding the normalization of maternal and newborn blood glucose, with weight and neuropsychomotor development applied with age, however, long-term evaluation, receiving more studies, end of observation, if there is a long term, there is some negative impact on life exposure to a metformin.
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spelling Uso de metformina na diabetes mellitus gestacional: uma revisão bibliográficaMetforminaDiabetes Mellitus GestacionalHiperglicemia GestacionalCNPQ::CIENCIAS DA SAUDE::MEDICINAGestational Diabetes Mellitus is a condition of hyperglycemic state during pregnancy, can lead to outcomes that are not favorable to the fetal maternal binomial, has frequent occurrence and a strong tendency to increase its incidence; its study is important to avoid possible complications with potential death. In this scenario, it is pertinent to update through the literature, on safety in the management of an oral antidiabetic to control this pathology. Identify from scientific studies or use of metformin in Gestational Diabetes Mellitus, an end of clarification, no current panorama, your solution for glycemic control in conjunction with safe pregnancy, as well as possible neuropsychomotor effects in the child. This is an exploratory bibliographic review, regarding the use of metformin without control of Gestational Diabetes Mellitus, using as databases: Latin American and Caribbean Literature in Health Sciences (LILACS), Scientific Eletronic Library Online (SCIELO ) and National Library of Medicine (PUBMED). A strong tendency was then identified to support the use of metformin in DMG, since, in the literature, no impediment was found to its management during pregnancy, there were positive results regarding the normalization of maternal and newborn blood glucose, with weight and neuropsychomotor development applied with age, however, long-term evaluation, receiving more studies, end of observation, if there is a long term, there is some negative impact on life exposure to a metformin.A Diabetes Mellitus Gestacional é uma condição de estado hiperglicêmico durante a gestação, podendo levar a desfechos pouco favoráveis ao binômio materno fetal, tem frequente ocorrência e forte tendência a aumento de sua incidência; seu estudo é importante para evitar possíveis complicações com potencial óbito. Nesse cenário, é pertinente a atualização por meio da literatura, sobre a segurança no manejo de um antidiabético oral para controle dessa patologia. Identificar a partir de estudos científicos o uso da metformina no Diabetes Mellitus Gestacional, a fim de esclarecer, no atual panorama, sua usabilidade para controle glicêmico em concomitância com segurança da gestação, bem como possíveis efeitos neuropsicomotores na criança. Trata-se de uma revisão bibliográfica de caráter exploratório, a respeito do uso da metformina no controle da Diabetes Mellitus Gestacional, utilizando as bases de dados: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Eletronic Library Online (SCIELO) e National Library of Medicine (PUBMED). Identifica-se então uma forte tendência ao apoio do uso da metformina na DMG, visto que, na literatura não foi encontrado nenhum impedimento ao seu manejo durante a gestação, verificou-se resultados positivos quanto a normalização da glicemia materna e recém nascidos saudáveis, com peso e desenvolvimento neuropsicomotor compatíveis com a idade, entretanto, a avaliação a longo prazo carece de mais estudos, a fim de observar se a longo prazo há algum impacto negativo na vida do feto exposto a metformina.Centro Universitário de João PessoaBrasilUNIPÊBaggio, Maria Cristina Rolimhttp://lattes.cnpq.br/4297151796663862Ferreira Filho, João Rosier2021-01-21T18:11:00Z2021-01-222021-01-21T18:11:00Z2020-07-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio.cruzeirodosul.edu.br/handle/123456789/1309porALQUDAH, A. et al. Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis. Diabetic Medicine, [s.l.], v. 35, n 2, p. 160–172, 2018. ISSN: 14645491, DOI: 10.1111/dme.13523. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29044702/. Acesso em: 15 out.2019. AMIN, M. et al. Comparison of Glyburide with Metformin in Treating Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. Clinical Drug Investigation, [s.l.], v. 35, n 6, p. 343–351, 2015. ISSN: 11791918, DOI: 10.1007/s40261-015-0289-3. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25985837/. Acesso em: 15 out.2019. BALSELLS, M. et al. Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: A systematic review and meta-analysis. BMJ, [s.l.], v. 350, n January, p. 1–12, 2015. ISSN: 17561833, DOI: 10.1136/bmj.h102. Disponível em: https://www.bmj.com/content/350/bmj.h102. Acesso em: 15 out.2019. BENNETT, C. J. et al. Attenuation of maternal weight gain impacts infant birthweight: Systematic review and meta-analysis. Journal of Developmental Origins of Health and Disease, [s.l.], v. 10, n 4, p. 387–405, 2019. ISSN: 20401752, DOI: 10.1017/S2040174418000879. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30411697/. Acesso em: 15 out.2019. BIDHENDI YARANDI, R. et al. Metformin therapy before conception versus throughout the pregnancy and risk of gestational diabetes mellitus in women with polycystic ovary syndrome: A systemic review, meta-analysis and meta-regression. Diabetology and Metabolic Syndrome, [s.l.], v. 11, n 1, p. 1–18, 2019. ISSN: 17585996, DOI: 10.1186/s13098-019-0453-7. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31367235/. Acesso em: 01 nov.2019. BISHOP, K. C. et al. Pharmacologic Treatment of Diabetes in Pregnancy. Obstetrical and Gynecological Survey, [s.l.], v. 74, n 5, p. 289–297, 2019. ISSN: 15339866, DOI: 10.1097/OGX.0000000000000671. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31098642/. Acesso em: 01 nov.2019. BLAIR, R. A.; ROSENBERG, E. A.; PALERMO, N. E. The Use of Non-insulin Agents in Gestational Diabetes: Clinical Considerations in Tailoring Therapy. Current Diabetes Reports, [s.l.], v. 19, n 12, p. 1–10, 2019. ISBN: 1189201912431, ISSN: 15390829, DOI: 10.1007/s11892-019-1243-1. Disponível em: https://pubmed.ncbi.nlm.nih.gov/9129543/. Acesso em: 01 nov.2019. BRIGGS, G. G.; AMBROSE, P. J.; NAGEOTTE, M. P.; PADILLA, G.; WAN, S. Excretion of metformin into breast milk and the effect on nursing infants. Obstet Gynecol. 2005;105:1437–41. Disponível em: https://pubmed.ncbi.nlm.nih.gov/15932841/. Acesso em: 15 out.2019. BROWN, J. et al. Insulin for the treatment of women with gestational diabetes ( Review ) Summary of findings for the main Comparison. [s.l.], n 11, 2017. DOI: 10.1002/14651858.CD012037.pub2.www.cochranelibrary.com. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513179/. Acesso em: 15 out.2019. BUTALIA, S. et al. Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis. Diabetic Medicine, [s.l.], v. 34, n 1, p. 27–36, 2017. ISSN: 14645491, DOI: 10.1111/dme.13150. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27150509/. Acesso em: 15 out.2019. CARLSEN, S. M.; MARTINUSSEN, M. P.; VANKY, E. Metformin’s effect on first-year weight gain: a follow-up study. Pediatrics. 2012;130 (5):e1222-1226. Disponível em: https://pubmed.ncbi.nlm.nih.gov/23071212/. Acesso em: 15 out.2019. DO CEU ALMEIDA, M. et al. Consenso “diabetes gestacional”: Atualização 2017. Revista Portuguesa de Diabetes, v. 12, n. 1, p. 24-38, 2017. Disponível em: https://www.researchgate.net/publication/329488271_Consenso_Diabetes_Gestacional_Atualizacao_2017_Consensus_on_Gestational_Diabetes_2017_Update. Acesso em: 15 out.2019. DODD, J. et al. Metformin for women who are obese during pregnancy versus standard care for improving maternal and infant outcomes - a systematic review. Journal of Paediatrics and Child Health, [s.l.], v. 49, n 7, p. 94, 2013. ISBN: 1034-4810, ISSN: 1034-4810, DOI: 10.1002/14651858.CD010564.pub2.www.cochranelibrary.com. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30039871/. Acesso em: 15 out.2019. FARRAR, D. et al. The identification and treatment of women with hyperglycaemia in pregnancy: An analysis of individual participant data, systematic reviews, meta-analyses and an economic evaluation. Health Technology Assessment, [s.l.], v. 20, n 86, p. 1–382, 2016. ISSN: 20464924, DOI: 10.3310/hta20860. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK401107/. Acesso em: 15 out.2019. FARRAR, D. et al. Treatments for gestational diabetes: A systematic review and meta-analysis. BMJ Open, [s.l.], v. 7, n 6, 2017. ISSN: 20446055, DOI: 10.1136/bmjopen-2016-015557. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28647726/. Acesso em: 15 out.2019. FEDERAÇÃO BRASILEIRA DAS ASSOCIAÇÕES DE GINECOLOGIA E OBSTETRÍCIA et al. Rastreamento e diagnóstico de diabetes mellitus gestacional no Brasil. 2016. Disponível em: http://bvsms.saude.gov.br/bvs/artigos/diabetes_mellitus_gestacional.pdf. Acesso em: 15 out.2019. FEIG, D. Meta-analysis suggests that metformin may reduce pre-eclampsia compared with insulin use during pregnancy. BMJ evidence-based medicine, v. 24, n. 2, p. 72-73, 2019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30108059/. Acesso em: 15 out.2019. FEGHALI, M. N.; UMANS, J. G.; CATALANO, P. M. Drugs to Control Diabetes During Pregnancy. Clinics in Perinatology, [s.l.], v. 46, n 2, p. 257–272, 2019. ISSN: 15579840, DOI: 10.1016/j.clp.2019.02.005. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31010559/. Acesso em: 03 dez.2019. FENG, Y.; YANG, H. Metformin–a potentially effective drug for gestational diabetes mellitus: a systematic review and meta-analysis. Journal of Maternal-Fetal and Neonatal Medicine, [s.l.], v. 30, n 15, p. 1874–1881, 2017. ISSN: 14764954, DOI: 10.1080/14767058.2016.1228061. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27549367/. Acesso em: 28 out.2019. FRANCISCO, R. P. V.; ZUGAIB, M.; TRIINDADE, T. C. Gestational diabetes, what did change in the criteria for diagnosis? Revista Brasileira de Ginecologia e Obstetricia, [s.l.], v. 33, n 8, p. 171–173, 2011. ISSN: 0100-7203, DOI: 10.1590/S0100-72032011000800001. Disponível em: https://www.researchgate.net/publication/51869518_Gestational_diabetes_what_did_change_in_the_criteria_for_diagnosis. Acesso em: 28 out.2019. GONZALEZ, C. D. et al. Metformin and Pregnancy Outcomes: Evidence Gaps and Unanswered Questions. Current Clinical Pharmacology, [s.l.], v. 14, n 1, p. 54–60, 2018. ISSN: 15748847, DOI: 10.2174/1574884714666181224151116. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30585549/. Acesso em: 28 out.2019. HALE, T. W.; KRISTENSEN, J. H.; HACKETT, L. P.; KOHAN, R.; ILETT, K. F. Transfer of metformin into human milk. Diabetologia. 2002;45:1509–14. Disponível em: https://pubmed.ncbi.nlm.nih.gov/12436333/. Acesso em: 28 out.2019. IJAS, H. et al. A follow-up of a randomised study of metformin and insulin in gestational diabetes mellitus: growth and development of the children at the age of 18 months. BJOG. 2014. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25039582/. Acesso em: 28 out.2019. IJAS, H. et al. Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study. BJOG. 2011;118:880-885. Disponível em: https://pubmed.ncbi.nlm.nih.gov/21083860/. Acesso em: 28 out.2019. KALAFAT, E. et al. Metformin for prevention of hypertensive disorders of pregnancy in women with gestational diabetes or obesity: systematic review and meta-analysis of randomized trials. Ultrasound in Obstetrics and Gynecology, [s.l.], v. 52, n 6, p. 706–714, 2018. ISSN: 14690705, DOI: 10.1002/uog.19084. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29749110/. Acesso em: 28 jan.2020. KAUTZKY-WILLER, A. et al. Clinical practice recommendations for diabetes in pregnancy (Update 2019). Wiener Klinische Wochenschrift, [s.l.], v. 131, p. 103–109, 2019. ISSN: 16137671, DOI: 10.1007/s00508-019-1456-y. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30980163/. Acesso em: 28 jan.2020. KUMAR, R. et al. Implementation and Evaluation of the "Metformin First" Protocol for Management of Gestational Diabetes. Can J Diabetes. 2019;43(8):554-559. doi:10.1016/j.jcjd.2019.06.005. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31562030/. Acesso em: 28 jan.2020. MADHUVRATA, P. et al. Prevention of gestational diabetes in pregnant women with risk factors for gestational diabetes: a systematic review and meta-analysis of randomised trials. Obstetric Medicine, [s.l.], v. 8, n 2, p. 68–85, 2015. ISSN: 17534968, DOI: 10.1177/1753495X15576673. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27512459/. Acesso em: 28 jan.2020. MARTIS, R. et al. Treatments for women with gestational diabetes mellitus: An overview of Cochrane systematic reviews. Cochrane Database of Systematic Reviews, [s.l.], v. 2018, n 8, 2018. ISSN: 1469493X, DOI: 10.1002/14651858.CD012327.pub2. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30103263/. Acesso em: 28 jan.2020. MCINTYRE, H. D. et al. Gestational diabetes mellitus. Nature Reviews Disease Primers, [s.l.], v. 5, n 1, 2019. ISBN: 0123456789, ISSN: 2056676X, DOI: 10.1038/s41572-019-0098-8. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31296866/. Acesso em: 28 jan.2020. MITRIC, C.; DESILETS, J.; BROWN, R. N. Recent advances in the antepartum management of diabetes. F1000Research, [s.l.], v. 8, n 5, p. 1–8, 2019. ISSN: 1759796X, DOI: 10.12688/f1000research.15795.1. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31119029/. Acesso em: 28 jan.2020. OLIVEIRA, J. E. P. (Org.) et al. Diretrizes da Sociedade Brasileira de Diabetes. São Paulo: Editora Clannad, 2018. Disponível em: https://www.diabetes.org.br/profissionais/images/2017/diretrizes/diretrizes-sbd-2017-2018.pdf. Acesso em: 15 mar.2020. ORGANIZAÇÃO PAN-AMERICANA DA SAÚDE; MINISTÉRIO DA SAÚDE; FEDERAÇÃO BRASILEIRA DAS ASSOCIAÇÕES DE GINECOLOGIA E OBSTETRÍCIA; SOCIEDADE BRASILEIRA DE DIABETES. Tratamento do diabetes mellitus gestacional no Brasil. Brasília, DF: OPAS, 2019. 57 p.: il. ISBN: 978-85-94091-12-3. Disponível em: https://www.diabetes.org.br/profissionais/images/pdf/Consenso_Brasileiro_Manejo_DMG_2019.pdf. Acesso em: 15 mar.2020. SILVA, P. Farmacologia. 8. ed., Rio de Janeiro: Guanabara Koogan, 2010. ROWAN, J. A. et al. Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age. Diabetes care. 2011;34(10):2279-2284. Disponível em: https://pubmed.ncbi.nlm.nih.gov/21949222/. Acesso em: 15 mar.2020. ROWAN, J. A. et al. Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7-9 years of age. BMJ Open Diabetes Res Care. 2011;6(1):e000456. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29682291/. Acesso em: 15 mar.2020. ROWAN, J. A.; HAGUE, W. M.; GAO, W.; BATTIN, M. R.; MOORE, M. P. MiG Trial Investigators. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med. 2008; 358:2003–15. Disponível em: https://pubmed.ncbi.nlm.nih.gov/18463376/. Acesso em: 15 mar.2020. TAN, X. et al. Effect of metformin treatment during pregnancy on women with PCOS: A systematic review and meta-analysis. Clinical and Investigative Medicine, [s.l.], v. 39, n 4, p. E120–E131, 2016. ISSN: 14882353, DOI: 10.25011/cim.v39i4.27091. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27619399/. Acesso em: 15 mar.2020. TARRY-ADKINS, J. L.; AIKEN, C. E.; OZANNE, S. E. Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis. PLoS Medicine, [s.l.], v. 16, n 8, p. 1–20, 2019. ISBN: 1111111111, ISSN: 15491676, DOI: 10.1371/journal.pmed.1002848. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31386659/. Acesso em: 25 mar.2020. TERTTI, K.; LAINE, K.; EKBLAD, U.; RINNE, V.; RONNEMAA, T. The degree of fetal metformin exposure does not influence fetal outcome in gestational diabetes mellitus. Acta Diabetol. 2014;51(5):731-738. Disponível em: https://pubmed.ncbi.nlm.nih.gov/24633859/. Acesso em: 25 mar.2020. TIEU, J. et al. Oral anti-diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational diabetes planning pregnancy, or pregnant women with pre-existing diabetes. Cochrane Database of Systematic Reviews, [s.l.], v. 2017, n 10, 2017. ISSN: 1469493X, DOI: 10.1002/14651858.CD007724.pub3. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29045765/. Acesso em: 25 mar.2020. XU, Q.; XIE, Q. Long-term effects of prenatal exposure to metformin on the health of children based on follow-up studies of randomized controlled trials: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics, [s.l.], v. 299, n 5, p. 1295–1303, 2019. ISBN: 0123456789, ISSN: 14320711, DOI: 10.1007/s00404-019-05124-w. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30953188/. Acesso em: 25 mar.2020. WEELDEN, W. VAN et al. Long-Term Effects of Oral Antidiabetic Drugs During Pregnancy on Offspring: A Systematic Review and Meta-analysis of Follow-up Studies of RCTs. Diabetes Therapy, [s.l.], v. 9, n 5, p. 1811–1829, 2018. ISSN: 18696961, DOI: 10.1007/s13300-018-0479-0. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30168045/. Acesso em: 25 mar.2020.info:eu-repo/semantics/openAccessreponame:Repositório do Centro Universitário Braz Cubasinstname:Centro Universitário Braz Cubas (CUB)instacron:CUB2021-03-19T14:40:49Zoai:repositorio.cruzeirodosul.edu.br:123456789/1309Repositório InstitucionalPUBhttps://repositorio.brazcubas.edu.br/oai/requestbibli@brazcubas.edu.bropendoar:2021-03-19T14:40:49Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)false
dc.title.none.fl_str_mv Uso de metformina na diabetes mellitus gestacional: uma revisão bibliográfica
title Uso de metformina na diabetes mellitus gestacional: uma revisão bibliográfica
spellingShingle Uso de metformina na diabetes mellitus gestacional: uma revisão bibliográfica
Ferreira Filho, João Rosier
Metformina
Diabetes Mellitus Gestacional
Hiperglicemia Gestacional
CNPQ::CIENCIAS DA SAUDE::MEDICINA
title_short Uso de metformina na diabetes mellitus gestacional: uma revisão bibliográfica
title_full Uso de metformina na diabetes mellitus gestacional: uma revisão bibliográfica
title_fullStr Uso de metformina na diabetes mellitus gestacional: uma revisão bibliográfica
title_full_unstemmed Uso de metformina na diabetes mellitus gestacional: uma revisão bibliográfica
title_sort Uso de metformina na diabetes mellitus gestacional: uma revisão bibliográfica
author Ferreira Filho, João Rosier
author_facet Ferreira Filho, João Rosier
author_role author
dc.contributor.none.fl_str_mv Baggio, Maria Cristina Rolim
http://lattes.cnpq.br/4297151796663862
dc.contributor.author.fl_str_mv Ferreira Filho, João Rosier
dc.subject.por.fl_str_mv Metformina
Diabetes Mellitus Gestacional
Hiperglicemia Gestacional
CNPQ::CIENCIAS DA SAUDE::MEDICINA
topic Metformina
Diabetes Mellitus Gestacional
Hiperglicemia Gestacional
CNPQ::CIENCIAS DA SAUDE::MEDICINA
description Gestational Diabetes Mellitus is a condition of hyperglycemic state during pregnancy, can lead to outcomes that are not favorable to the fetal maternal binomial, has frequent occurrence and a strong tendency to increase its incidence; its study is important to avoid possible complications with potential death. In this scenario, it is pertinent to update through the literature, on safety in the management of an oral antidiabetic to control this pathology. Identify from scientific studies or use of metformin in Gestational Diabetes Mellitus, an end of clarification, no current panorama, your solution for glycemic control in conjunction with safe pregnancy, as well as possible neuropsychomotor effects in the child. This is an exploratory bibliographic review, regarding the use of metformin without control of Gestational Diabetes Mellitus, using as databases: Latin American and Caribbean Literature in Health Sciences (LILACS), Scientific Eletronic Library Online (SCIELO ) and National Library of Medicine (PUBMED). A strong tendency was then identified to support the use of metformin in DMG, since, in the literature, no impediment was found to its management during pregnancy, there were positive results regarding the normalization of maternal and newborn blood glucose, with weight and neuropsychomotor development applied with age, however, long-term evaluation, receiving more studies, end of observation, if there is a long term, there is some negative impact on life exposure to a metformin.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-17
2021-01-21T18:11:00Z
2021-01-22
2021-01-21T18:11:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.cruzeirodosul.edu.br/handle/123456789/1309
url https://repositorio.cruzeirodosul.edu.br/handle/123456789/1309
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv ALQUDAH, A. et al. Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis. Diabetic Medicine, [s.l.], v. 35, n 2, p. 160–172, 2018. ISSN: 14645491, DOI: 10.1111/dme.13523. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29044702/. Acesso em: 15 out.2019. AMIN, M. et al. Comparison of Glyburide with Metformin in Treating Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. Clinical Drug Investigation, [s.l.], v. 35, n 6, p. 343–351, 2015. ISSN: 11791918, DOI: 10.1007/s40261-015-0289-3. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25985837/. Acesso em: 15 out.2019. BALSELLS, M. et al. Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: A systematic review and meta-analysis. BMJ, [s.l.], v. 350, n January, p. 1–12, 2015. ISSN: 17561833, DOI: 10.1136/bmj.h102. Disponível em: https://www.bmj.com/content/350/bmj.h102. Acesso em: 15 out.2019. BENNETT, C. J. et al. Attenuation of maternal weight gain impacts infant birthweight: Systematic review and meta-analysis. Journal of Developmental Origins of Health and Disease, [s.l.], v. 10, n 4, p. 387–405, 2019. ISSN: 20401752, DOI: 10.1017/S2040174418000879. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30411697/. Acesso em: 15 out.2019. BIDHENDI YARANDI, R. et al. Metformin therapy before conception versus throughout the pregnancy and risk of gestational diabetes mellitus in women with polycystic ovary syndrome: A systemic review, meta-analysis and meta-regression. Diabetology and Metabolic Syndrome, [s.l.], v. 11, n 1, p. 1–18, 2019. ISSN: 17585996, DOI: 10.1186/s13098-019-0453-7. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31367235/. Acesso em: 01 nov.2019. BISHOP, K. C. et al. Pharmacologic Treatment of Diabetes in Pregnancy. Obstetrical and Gynecological Survey, [s.l.], v. 74, n 5, p. 289–297, 2019. ISSN: 15339866, DOI: 10.1097/OGX.0000000000000671. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31098642/. Acesso em: 01 nov.2019. BLAIR, R. A.; ROSENBERG, E. A.; PALERMO, N. E. The Use of Non-insulin Agents in Gestational Diabetes: Clinical Considerations in Tailoring Therapy. Current Diabetes Reports, [s.l.], v. 19, n 12, p. 1–10, 2019. ISBN: 1189201912431, ISSN: 15390829, DOI: 10.1007/s11892-019-1243-1. Disponível em: https://pubmed.ncbi.nlm.nih.gov/9129543/. Acesso em: 01 nov.2019. BRIGGS, G. G.; AMBROSE, P. J.; NAGEOTTE, M. P.; PADILLA, G.; WAN, S. Excretion of metformin into breast milk and the effect on nursing infants. Obstet Gynecol. 2005;105:1437–41. Disponível em: https://pubmed.ncbi.nlm.nih.gov/15932841/. Acesso em: 15 out.2019. BROWN, J. et al. Insulin for the treatment of women with gestational diabetes ( Review ) Summary of findings for the main Comparison. [s.l.], n 11, 2017. DOI: 10.1002/14651858.CD012037.pub2.www.cochranelibrary.com. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513179/. Acesso em: 15 out.2019. BUTALIA, S. et al. Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis. Diabetic Medicine, [s.l.], v. 34, n 1, p. 27–36, 2017. ISSN: 14645491, DOI: 10.1111/dme.13150. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27150509/. Acesso em: 15 out.2019. CARLSEN, S. M.; MARTINUSSEN, M. P.; VANKY, E. Metformin’s effect on first-year weight gain: a follow-up study. Pediatrics. 2012;130 (5):e1222-1226. Disponível em: https://pubmed.ncbi.nlm.nih.gov/23071212/. Acesso em: 15 out.2019. DO CEU ALMEIDA, M. et al. Consenso “diabetes gestacional”: Atualização 2017. Revista Portuguesa de Diabetes, v. 12, n. 1, p. 24-38, 2017. Disponível em: https://www.researchgate.net/publication/329488271_Consenso_Diabetes_Gestacional_Atualizacao_2017_Consensus_on_Gestational_Diabetes_2017_Update. Acesso em: 15 out.2019. DODD, J. et al. Metformin for women who are obese during pregnancy versus standard care for improving maternal and infant outcomes - a systematic review. Journal of Paediatrics and Child Health, [s.l.], v. 49, n 7, p. 94, 2013. ISBN: 1034-4810, ISSN: 1034-4810, DOI: 10.1002/14651858.CD010564.pub2.www.cochranelibrary.com. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30039871/. Acesso em: 15 out.2019. FARRAR, D. et al. The identification and treatment of women with hyperglycaemia in pregnancy: An analysis of individual participant data, systematic reviews, meta-analyses and an economic evaluation. Health Technology Assessment, [s.l.], v. 20, n 86, p. 1–382, 2016. ISSN: 20464924, DOI: 10.3310/hta20860. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK401107/. Acesso em: 15 out.2019. FARRAR, D. et al. Treatments for gestational diabetes: A systematic review and meta-analysis. BMJ Open, [s.l.], v. 7, n 6, 2017. ISSN: 20446055, DOI: 10.1136/bmjopen-2016-015557. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28647726/. Acesso em: 15 out.2019. FEDERAÇÃO BRASILEIRA DAS ASSOCIAÇÕES DE GINECOLOGIA E OBSTETRÍCIA et al. Rastreamento e diagnóstico de diabetes mellitus gestacional no Brasil. 2016. Disponível em: http://bvsms.saude.gov.br/bvs/artigos/diabetes_mellitus_gestacional.pdf. Acesso em: 15 out.2019. FEIG, D. Meta-analysis suggests that metformin may reduce pre-eclampsia compared with insulin use during pregnancy. BMJ evidence-based medicine, v. 24, n. 2, p. 72-73, 2019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30108059/. Acesso em: 15 out.2019. FEGHALI, M. N.; UMANS, J. G.; CATALANO, P. M. Drugs to Control Diabetes During Pregnancy. Clinics in Perinatology, [s.l.], v. 46, n 2, p. 257–272, 2019. ISSN: 15579840, DOI: 10.1016/j.clp.2019.02.005. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31010559/. Acesso em: 03 dez.2019. FENG, Y.; YANG, H. Metformin–a potentially effective drug for gestational diabetes mellitus: a systematic review and meta-analysis. Journal of Maternal-Fetal and Neonatal Medicine, [s.l.], v. 30, n 15, p. 1874–1881, 2017. ISSN: 14764954, DOI: 10.1080/14767058.2016.1228061. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27549367/. Acesso em: 28 out.2019. FRANCISCO, R. P. V.; ZUGAIB, M.; TRIINDADE, T. C. Gestational diabetes, what did change in the criteria for diagnosis? Revista Brasileira de Ginecologia e Obstetricia, [s.l.], v. 33, n 8, p. 171–173, 2011. ISSN: 0100-7203, DOI: 10.1590/S0100-72032011000800001. Disponível em: https://www.researchgate.net/publication/51869518_Gestational_diabetes_what_did_change_in_the_criteria_for_diagnosis. Acesso em: 28 out.2019. GONZALEZ, C. D. et al. Metformin and Pregnancy Outcomes: Evidence Gaps and Unanswered Questions. Current Clinical Pharmacology, [s.l.], v. 14, n 1, p. 54–60, 2018. ISSN: 15748847, DOI: 10.2174/1574884714666181224151116. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30585549/. Acesso em: 28 out.2019. HALE, T. W.; KRISTENSEN, J. H.; HACKETT, L. P.; KOHAN, R.; ILETT, K. F. Transfer of metformin into human milk. Diabetologia. 2002;45:1509–14. Disponível em: https://pubmed.ncbi.nlm.nih.gov/12436333/. Acesso em: 28 out.2019. IJAS, H. et al. A follow-up of a randomised study of metformin and insulin in gestational diabetes mellitus: growth and development of the children at the age of 18 months. BJOG. 2014. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25039582/. Acesso em: 28 out.2019. IJAS, H. et al. Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study. BJOG. 2011;118:880-885. Disponível em: https://pubmed.ncbi.nlm.nih.gov/21083860/. Acesso em: 28 out.2019. KALAFAT, E. et al. Metformin for prevention of hypertensive disorders of pregnancy in women with gestational diabetes or obesity: systematic review and meta-analysis of randomized trials. Ultrasound in Obstetrics and Gynecology, [s.l.], v. 52, n 6, p. 706–714, 2018. ISSN: 14690705, DOI: 10.1002/uog.19084. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29749110/. Acesso em: 28 jan.2020. KAUTZKY-WILLER, A. et al. Clinical practice recommendations for diabetes in pregnancy (Update 2019). Wiener Klinische Wochenschrift, [s.l.], v. 131, p. 103–109, 2019. ISSN: 16137671, DOI: 10.1007/s00508-019-1456-y. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30980163/. Acesso em: 28 jan.2020. KUMAR, R. et al. Implementation and Evaluation of the "Metformin First" Protocol for Management of Gestational Diabetes. Can J Diabetes. 2019;43(8):554-559. doi:10.1016/j.jcjd.2019.06.005. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31562030/. Acesso em: 28 jan.2020. MADHUVRATA, P. et al. Prevention of gestational diabetes in pregnant women with risk factors for gestational diabetes: a systematic review and meta-analysis of randomised trials. Obstetric Medicine, [s.l.], v. 8, n 2, p. 68–85, 2015. ISSN: 17534968, DOI: 10.1177/1753495X15576673. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27512459/. Acesso em: 28 jan.2020. MARTIS, R. et al. Treatments for women with gestational diabetes mellitus: An overview of Cochrane systematic reviews. Cochrane Database of Systematic Reviews, [s.l.], v. 2018, n 8, 2018. ISSN: 1469493X, DOI: 10.1002/14651858.CD012327.pub2. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30103263/. Acesso em: 28 jan.2020. MCINTYRE, H. D. et al. Gestational diabetes mellitus. Nature Reviews Disease Primers, [s.l.], v. 5, n 1, 2019. ISBN: 0123456789, ISSN: 2056676X, DOI: 10.1038/s41572-019-0098-8. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31296866/. Acesso em: 28 jan.2020. MITRIC, C.; DESILETS, J.; BROWN, R. N. Recent advances in the antepartum management of diabetes. F1000Research, [s.l.], v. 8, n 5, p. 1–8, 2019. ISSN: 1759796X, DOI: 10.12688/f1000research.15795.1. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31119029/. Acesso em: 28 jan.2020. OLIVEIRA, J. E. P. (Org.) et al. Diretrizes da Sociedade Brasileira de Diabetes. São Paulo: Editora Clannad, 2018. Disponível em: https://www.diabetes.org.br/profissionais/images/2017/diretrizes/diretrizes-sbd-2017-2018.pdf. Acesso em: 15 mar.2020. ORGANIZAÇÃO PAN-AMERICANA DA SAÚDE; MINISTÉRIO DA SAÚDE; FEDERAÇÃO BRASILEIRA DAS ASSOCIAÇÕES DE GINECOLOGIA E OBSTETRÍCIA; SOCIEDADE BRASILEIRA DE DIABETES. Tratamento do diabetes mellitus gestacional no Brasil. Brasília, DF: OPAS, 2019. 57 p.: il. ISBN: 978-85-94091-12-3. Disponível em: https://www.diabetes.org.br/profissionais/images/pdf/Consenso_Brasileiro_Manejo_DMG_2019.pdf. Acesso em: 15 mar.2020. SILVA, P. Farmacologia. 8. ed., Rio de Janeiro: Guanabara Koogan, 2010. ROWAN, J. A. et al. Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age. Diabetes care. 2011;34(10):2279-2284. Disponível em: https://pubmed.ncbi.nlm.nih.gov/21949222/. Acesso em: 15 mar.2020. ROWAN, J. A. et al. Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7-9 years of age. BMJ Open Diabetes Res Care. 2011;6(1):e000456. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29682291/. Acesso em: 15 mar.2020. ROWAN, J. A.; HAGUE, W. M.; GAO, W.; BATTIN, M. R.; MOORE, M. P. MiG Trial Investigators. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med. 2008; 358:2003–15. Disponível em: https://pubmed.ncbi.nlm.nih.gov/18463376/. Acesso em: 15 mar.2020. TAN, X. et al. Effect of metformin treatment during pregnancy on women with PCOS: A systematic review and meta-analysis. Clinical and Investigative Medicine, [s.l.], v. 39, n 4, p. E120–E131, 2016. ISSN: 14882353, DOI: 10.25011/cim.v39i4.27091. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27619399/. Acesso em: 15 mar.2020. TARRY-ADKINS, J. L.; AIKEN, C. E.; OZANNE, S. E. Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis. PLoS Medicine, [s.l.], v. 16, n 8, p. 1–20, 2019. ISBN: 1111111111, ISSN: 15491676, DOI: 10.1371/journal.pmed.1002848. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31386659/. Acesso em: 25 mar.2020. TERTTI, K.; LAINE, K.; EKBLAD, U.; RINNE, V.; RONNEMAA, T. The degree of fetal metformin exposure does not influence fetal outcome in gestational diabetes mellitus. Acta Diabetol. 2014;51(5):731-738. Disponível em: https://pubmed.ncbi.nlm.nih.gov/24633859/. Acesso em: 25 mar.2020. TIEU, J. et al. Oral anti-diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational diabetes planning pregnancy, or pregnant women with pre-existing diabetes. Cochrane Database of Systematic Reviews, [s.l.], v. 2017, n 10, 2017. ISSN: 1469493X, DOI: 10.1002/14651858.CD007724.pub3. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29045765/. Acesso em: 25 mar.2020. XU, Q.; XIE, Q. Long-term effects of prenatal exposure to metformin on the health of children based on follow-up studies of randomized controlled trials: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics, [s.l.], v. 299, n 5, p. 1295–1303, 2019. ISBN: 0123456789, ISSN: 14320711, DOI: 10.1007/s00404-019-05124-w. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30953188/. Acesso em: 25 mar.2020. WEELDEN, W. VAN et al. Long-Term Effects of Oral Antidiabetic Drugs During Pregnancy on Offspring: A Systematic Review and Meta-analysis of Follow-up Studies of RCTs. Diabetes Therapy, [s.l.], v. 9, n 5, p. 1811–1829, 2018. ISSN: 18696961, DOI: 10.1007/s13300-018-0479-0. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30168045/. Acesso em: 25 mar.2020.
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publisher.none.fl_str_mv Centro Universitário de João Pessoa
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