As complexidades na imunoterapia T-CAR para pacientes com leucemia limfoblástica aguda

• Autor(a) principal: Gatti, Barbara Guimarães
• Data de Publicação: 2019
• Outros Autores: Sabino, Bruna Amorim, Pinheiro, Bruna Muniz, Tavares Filho, Claudiney Marques, Santos, Débora Vicente, Oliveira, Larissa Aparecida de, Chaves, Leandro Santos Ferreira
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório do Centro Universitário Braz Cubas
• Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/346
• topic: Imunoterapia; Imunoterapia; CD19; Receptor quimérico de antígeno; CNPQ::OUTROS::BIOMEDICINA

Treatment with T-CAR or CAR-T cells (T-Lymphocytes with Chimeric Antigen Receptors) is one of the methods of cancer immunotherapy and has been used for the treatment of acute lymphoblastic leukemia (ALL) and other lymphomas. Having the T lymphocyte genetically modified with a CAR molecule on the surface that acts as a specific tumor cell receptor, which increases the destructive capacity of lymphocytes, since this modified molecule has the power to cause cytotoxicity to the antigen expressed on the surface of the infected cell. This literature review aimed to highlight the difficulties of this therapy, so that in the future modifications are made in order to improve it. It had a very large success with B-cell lymphoid neoplasms (recurrent and refractory), and there is also the possibility to treat some solid cancers. Acting specifically on the recognition of CD19, which is a marker of available B lineage on the tumor surface and which is expressed throughout the cell maturation process and found in most pathologies of lineage B, it suffers cytotoxicity causing reissue in the multiplication. This treatment is made from a process called leukopheresis. However the use of this treatment have some complexities and limitations, as any cancer treatment, CAR-T therapy also has side effects and other complexities that may be corrected in the future. The study of techniques aimed at reducing adverse effects can bring promising results.