Revisão Sistemática de método misto sobre o microgênero: sexo é um viés de pesquisa em estudos com humanos

• Autor(a) principal: Aquino, Mariana Vieira de
• Data de Publicação: 2021
• Outros Autores: Bordieri, Sara Sans Amaral
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório do Centro Universitário Braz Cubas
• Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/3518
• topic: Microgênero; Microbiota intestinal; Viés de sexo; Humanos; Diferenças sexuais; CNPQ::CIENCIAS DA SAUDE::NUTRICAO

Goals: The aim of this systematic review is to investigate whether microgenderrome is a research bias for studies in humans. Background: A recent review of rat studies identified bidirectional sex-dependent differences in gut microbiota function, composition, and effects. The influence of sex on the enteric community can be an important bias to be considered in the design of research studies on this topic. Study: A mixed method systematic review of qualitative convergence was carried out in line with the guidelines of the checklist and flowchart proposed by PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Studies carried out between 2001 and 2021, indexed in PubMed/MEDLINE, EMBASE or Science Direct, in the English language, were synthesized. The research designs included were: observational analytical studies and experimental tests. Results: 4,774 articles were identified. After reading the titles and abstracts, 13 articles met the eligibility criteria and were analyzed. The results showed sex-dependent differences in the composition of the intestinal microbiota; influence of sex hormones; correlation between body mass index (BMI), sex and microbiota; sex-specific differences in the interaction between microbiota and different diseases; possible bidirectional sex-specific interaction between medications and the enteric community; and differences arising from dietary interventions. Conclusions: Our findings confirm that sex is a research bias in humans. We point out the need for more randomized controlled trials to unravel the relationship between sex, sex hormones and intestinal microbiota, mainly with regard to composition and function.