Benefícios do uso do PET/CT na doença de Rosai-Dorfman: relato de caso

• Autor(a) principal: Alves , Vanessa Araújo
• Data de Publicação: 2020
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório do Centro Universitário Braz Cubas
• Texto Completo: https://repositorio.cruzeirodosul.edu.br/handle/123456789/1469
• topic: Rosai-Dorfman; Extra nodal; Histiocitose sinusal; Tomografia por emissão de pósitrons; CNPQ::CIENCIAS DA SAUDE::MEDICINA

INTRODUCTION: Rosai-Dorfman Disease (DRD), also known as Sinus Histiocytosis, is a benign and rare histiocytic disorder of unknown etiology. Clinically, in most cases, it manifests as a massive and painless lymphadenopathy, especially in the cervical region. Extranodal involvement has been documented in approximately 40% of cases. The use of [18F]FDG on PET/CT is a well established tool in the diagnosis, staging and follow-up of malignant neoplasms. However, there is a great expansion of the indications of this method, as it is very effective and highly sensitive in the follow-up of patients with benign diseases, such as Rosai Dorfman's disease. OBJECTIVES: This study aimed to report a clinical case of RosaiDorfman Disease with extranodal involvement. It was described the clinical presentation of the disease, histological characteristics, diagnosis and treatment. The use of PET/CT in the followup of the disease was discussed, thus defending the benefits of its use. For this purpose, it was intended to highlight more updated cases in which such examination was a useful tool for the diagnosis and staging of the disease. MATERIALS AND METHODS: The work developed is a descriptive and observational study, of the case report type, which described an unusual case of Rosai-Dorfman's Disease, accompanied at the Paraiba Oncology Center (João Pessoa, Paraíba), with data obtained through medical records. RESULTS AND DISCUSSION: This is a relevant study for presenting an unusual case of Rosai-Dorfman disease, which reinforces the need for implementation of new modalities of diagnosis and staging to the future protocols of DRD, which will help in a more careful decision of the best approach for the treatment of the disease. The PET/CT proved to be an appropriate tool to perform the initial evaluation of the extension of the disease, as well as the response to the therapy instituted, also avoiding patients from being submitted to excessive and often ineffective procedures. CONCLUSION: The present study reported an unusual case of Rosai-Dorfman disease with extranodal involvement, in which PET/CT was used, helping in the treatment decision. The clinical presentation of the disease was discussed, as well as its diagnosis and treatment, poiting that there is still an uncertain understanding about the DRD pathogenesis, and this translates into a wide variety of therapeutic modalities, which will not always be effective for all patients.