Diagnóstico diferencial do glioblastoma por imagem molecular
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório do Centro Universitário Braz Cubas |
Texto Completo: | https://repositorio.cruzeirodosul.edu.br/handle/123456789/3202 |
Resumo: | According to the World Health Organization (WHO), Central Nervous System (CNS) tumors are classified based on molecular parameters that are potentially important for their diagnosis. Among the tumor types, glioblastoma is the most common astrocytoma, being rated as grade IV. The grade attribution for the most cytologically malignant neoplasms is associated with infiltration, proliferation, and fast progression of the disease. And for the diagnosis of this disease to be identified, minimizing its progression, a method used in Molecular Imaging has been widely studied. In particular , a Positron Emission Tomography coupled to Computed Tomography (PET-CT) that involves image acquisition, at the molecular level often, allows obtaining information related to the diseases pathophysiology. This feature makes it a fundamental tool for the differential diagnosis of tumors, especially when the radiopharmaceutical used is the specific target. In this sense, the clinical aspects obtained with PET-CT allows an early diagnosis with a consequent increase in the survival of patients with glioblastoma. This literature review aims to highlight and compare the radiopharmaceuticals: fluorodeoxyglucose-fluor-18 (FDG- 18 F), fluoroethyltyrosine-fluor-18 (FET- 18 F) and methionine-carbon-11 (methionine- 11 C), to demonstrate their particularities and its positive and negative aspects in relation to the differential diagnosis of glioblastoma. |
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Diagnóstico diferencial do glioblastoma por imagem molecularDifferential diagnosis of glioblastoma by molecular imagingSistema Nervoso CentralCarcinomaGlioblastomaRadiofármacoImagem MolecularCiências BiológicasAccording to the World Health Organization (WHO), Central Nervous System (CNS) tumors are classified based on molecular parameters that are potentially important for their diagnosis. Among the tumor types, glioblastoma is the most common astrocytoma, being rated as grade IV. The grade attribution for the most cytologically malignant neoplasms is associated with infiltration, proliferation, and fast progression of the disease. And for the diagnosis of this disease to be identified, minimizing its progression, a method used in Molecular Imaging has been widely studied. In particular , a Positron Emission Tomography coupled to Computed Tomography (PET-CT) that involves image acquisition, at the molecular level often, allows obtaining information related to the diseases pathophysiology. This feature makes it a fundamental tool for the differential diagnosis of tumors, especially when the radiopharmaceutical used is the specific target. In this sense, the clinical aspects obtained with PET-CT allows an early diagnosis with a consequent increase in the survival of patients with glioblastoma. This literature review aims to highlight and compare the radiopharmaceuticals: fluorodeoxyglucose-fluor-18 (FDG- 18 F), fluoroethyltyrosine-fluor-18 (FET- 18 F) and methionine-carbon-11 (methionine- 11 C), to demonstrate their particularities and its positive and negative aspects in relation to the differential diagnosis of glioblastoma.De acordo com a Organização Mundial da Saúde (OMS), os tumores do Sistema Nervoso Central (SNC) são classificados a partir de parâmetros moleculares potencialmente importantes para seu diagnóstico. Dentre os tipos tumorais, o glioblastoma é o astrocitoma mais comum, sendo classificado como grau IV. A atribuição do grau às neoplasmas citologicamente mais malignos está associada a infiltração, proliferação e evolução rápida da doença. Um diagnóstico preciso e precoce é almejado para minimizar sua progressão. O método de Imagem Molecular utilizando radiofármacos está sendo amplamente estudado pela Tomografia por Emissão de Pósitrons acoplada à Tomografia Computadorizada (PET-TC) que envolve a aquisição de imagens que permitem a obtenção de informações relacionadas à fisiopatologia das doenças. Esta característica a torna uma ferramenta fundamental para o diagnóstico diferencial de tumores, especialmente quando o radiofármaco utilizado é alvo específico. Nesse sentido, os aspectos clínicos obtidos com a PET-TC permitem um diagnóstico precoce com consequente aumento da sobrevida do paciente com glioblastoma. Esta revisão da literatura tem por intuito evidenciar e comparar os radiofármacos: fluorodeoxiglicose-flúor-18 (FDG- 18 F), fluoroetiltirosina-flúor-18 (FET- 18 F) e metionina-carbono-11 (metionina- 11 C), para demonstrar suas particularidades e seus aspectos positivos e negativos em relação ao diagnóstico diferencial do glioblastoma.Universidade Cruzeiro do SulBrasilUNICSUL2022-02-23T16:00:03Z2021-11-112022-02-23T16:00:03Z2021-11-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio.cruzeirodosul.edu.br/handle/123456789/3202porUniversidade Cruzeiro do SulSouza, Stefanie LopesRamos, Susan FariasAnjos, Vivian Genovez dosLima, Cilene Rebouças deMiranda, Ana Cláudia Camargoinfo:eu-repo/semantics/openAccessreponame:Repositório do Centro Universitário Braz Cubasinstname:Centro Universitário Braz Cubas (CUB)instacron:CUB2022-11-08T11:43:42Zoai:repositorio.cruzeirodosul.edu.br:123456789/3202Repositório InstitucionalPUBhttps://repositorio.brazcubas.edu.br/oai/requestbibli@brazcubas.edu.bropendoar:2022-11-08T11:43:42Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB)false |
dc.title.none.fl_str_mv |
Diagnóstico diferencial do glioblastoma por imagem molecular Differential diagnosis of glioblastoma by molecular imaging |
title |
Diagnóstico diferencial do glioblastoma por imagem molecular |
spellingShingle |
Diagnóstico diferencial do glioblastoma por imagem molecular Souza, Stefanie Lopes Sistema Nervoso Central Carcinoma Glioblastoma Radiofármaco Imagem Molecular Ciências Biológicas |
title_short |
Diagnóstico diferencial do glioblastoma por imagem molecular |
title_full |
Diagnóstico diferencial do glioblastoma por imagem molecular |
title_fullStr |
Diagnóstico diferencial do glioblastoma por imagem molecular |
title_full_unstemmed |
Diagnóstico diferencial do glioblastoma por imagem molecular |
title_sort |
Diagnóstico diferencial do glioblastoma por imagem molecular |
author |
Souza, Stefanie Lopes |
author_facet |
Souza, Stefanie Lopes Ramos, Susan Farias Anjos, Vivian Genovez dos Lima, Cilene Rebouças de Miranda, Ana Cláudia Camargo |
author_role |
author |
author2 |
Ramos, Susan Farias Anjos, Vivian Genovez dos Lima, Cilene Rebouças de Miranda, Ana Cláudia Camargo |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Souza, Stefanie Lopes Ramos, Susan Farias Anjos, Vivian Genovez dos Lima, Cilene Rebouças de Miranda, Ana Cláudia Camargo |
dc.subject.por.fl_str_mv |
Sistema Nervoso Central Carcinoma Glioblastoma Radiofármaco Imagem Molecular Ciências Biológicas |
topic |
Sistema Nervoso Central Carcinoma Glioblastoma Radiofármaco Imagem Molecular Ciências Biológicas |
description |
According to the World Health Organization (WHO), Central Nervous System (CNS) tumors are classified based on molecular parameters that are potentially important for their diagnosis. Among the tumor types, glioblastoma is the most common astrocytoma, being rated as grade IV. The grade attribution for the most cytologically malignant neoplasms is associated with infiltration, proliferation, and fast progression of the disease. And for the diagnosis of this disease to be identified, minimizing its progression, a method used in Molecular Imaging has been widely studied. In particular , a Positron Emission Tomography coupled to Computed Tomography (PET-CT) that involves image acquisition, at the molecular level often, allows obtaining information related to the diseases pathophysiology. This feature makes it a fundamental tool for the differential diagnosis of tumors, especially when the radiopharmaceutical used is the specific target. In this sense, the clinical aspects obtained with PET-CT allows an early diagnosis with a consequent increase in the survival of patients with glioblastoma. This literature review aims to highlight and compare the radiopharmaceuticals: fluorodeoxyglucose-fluor-18 (FDG- 18 F), fluoroethyltyrosine-fluor-18 (FET- 18 F) and methionine-carbon-11 (methionine- 11 C), to demonstrate their particularities and its positive and negative aspects in relation to the differential diagnosis of glioblastoma. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-11 2021-11-11 2022-02-23T16:00:03Z 2022-02-23T16:00:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/3202 |
url |
https://repositorio.cruzeirodosul.edu.br/handle/123456789/3202 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Universidade Cruzeiro do Sul |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Cruzeiro do Sul Brasil UNICSUL |
publisher.none.fl_str_mv |
Universidade Cruzeiro do Sul Brasil UNICSUL |
dc.source.none.fl_str_mv |
reponame:Repositório do Centro Universitário Braz Cubas instname:Centro Universitário Braz Cubas (CUB) instacron:CUB |
instname_str |
Centro Universitário Braz Cubas (CUB) |
instacron_str |
CUB |
institution |
CUB |
reponame_str |
Repositório do Centro Universitário Braz Cubas |
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Repositório do Centro Universitário Braz Cubas |
repository.name.fl_str_mv |
Repositório do Centro Universitário Braz Cubas - Centro Universitário Braz Cubas (CUB) |
repository.mail.fl_str_mv |
bibli@brazcubas.edu.br |
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