Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Pesquisa Veterinária Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000400290 |
Resumo: | Abstract Since respiratory insufficiency is the main cause of death in patients affected by Duchenne Muscular Dystrophy (DMD), the present study aims at establishing a new non-invasive method to evaluate the clinical parameters of respiratory conditions of experimental models affected by DMD. With this purpose in mind, we evaluated the cardiorespiratory clinical conditions, the changes in the intercostal muscles, the diaphragmatic mobility, and the respiratory cycles in Golden Retriever Muscular Dystrophy (GRMD) employing ultrasonography (US). A control group consisting of dogs of the same race, but not affected by muscular dystrophy, were used in this study. The results showed that inspiration, expiration and plateau movements (diaphragm mobility) were lower in the affected group. Plateau phase in the affected group was practically non-existent and showed that the diaphragm remained in constant motion. Respiratory rate reached 15.5 per minute for affected group and 26.93 per minute for the control group. Expiration and inspiration movements of intercostal muscles reached 8.99mm and 8.79mm, respectively, for control group and 7.42mm and 7.40mm, respectively, for affected group. Methodology used in the present analysis proved to be viable for the follow-up and evaluation of the respiratory model in GRMD and may be adapted to other muscular dystrophy experimental models. |
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Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular DystrophyRespiratory musclesDuchenne Muscular DystrophydiaphragmDMDGRMDultrasoundAbstract Since respiratory insufficiency is the main cause of death in patients affected by Duchenne Muscular Dystrophy (DMD), the present study aims at establishing a new non-invasive method to evaluate the clinical parameters of respiratory conditions of experimental models affected by DMD. With this purpose in mind, we evaluated the cardiorespiratory clinical conditions, the changes in the intercostal muscles, the diaphragmatic mobility, and the respiratory cycles in Golden Retriever Muscular Dystrophy (GRMD) employing ultrasonography (US). A control group consisting of dogs of the same race, but not affected by muscular dystrophy, were used in this study. The results showed that inspiration, expiration and plateau movements (diaphragm mobility) were lower in the affected group. Plateau phase in the affected group was practically non-existent and showed that the diaphragm remained in constant motion. Respiratory rate reached 15.5 per minute for affected group and 26.93 per minute for the control group. Expiration and inspiration movements of intercostal muscles reached 8.99mm and 8.79mm, respectively, for control group and 7.42mm and 7.40mm, respectively, for affected group. Methodology used in the present analysis proved to be viable for the follow-up and evaluation of the respiratory model in GRMD and may be adapted to other muscular dystrophy experimental models.Colégio Brasileiro de Patologia Animal - CBPA2016-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000400290Pesquisa Veterinária Brasileira v.36 n.4 2016reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/S0100-736X2016000400007info:eu-repo/semantics/openAccessOliveira,Daniela M.Hagen,Stefano C.Santos,Amilton C.Miglino,Maria A.Assis Neto,Antônio C.eng2016-07-15T00:00:00Zoai:scielo:S0100-736X2016000400290Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2016-07-15T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy |
title |
Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy |
spellingShingle |
Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy Oliveira,Daniela M. Respiratory muscles Duchenne Muscular Dystrophy diaphragm DMD GRMD ultrasound |
title_short |
Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy |
title_full |
Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy |
title_fullStr |
Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy |
title_full_unstemmed |
Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy |
title_sort |
Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy |
author |
Oliveira,Daniela M. |
author_facet |
Oliveira,Daniela M. Hagen,Stefano C. Santos,Amilton C. Miglino,Maria A. Assis Neto,Antônio C. |
author_role |
author |
author2 |
Hagen,Stefano C. Santos,Amilton C. Miglino,Maria A. Assis Neto,Antônio C. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Daniela M. Hagen,Stefano C. Santos,Amilton C. Miglino,Maria A. Assis Neto,Antônio C. |
dc.subject.por.fl_str_mv |
Respiratory muscles Duchenne Muscular Dystrophy diaphragm DMD GRMD ultrasound |
topic |
Respiratory muscles Duchenne Muscular Dystrophy diaphragm DMD GRMD ultrasound |
description |
Abstract Since respiratory insufficiency is the main cause of death in patients affected by Duchenne Muscular Dystrophy (DMD), the present study aims at establishing a new non-invasive method to evaluate the clinical parameters of respiratory conditions of experimental models affected by DMD. With this purpose in mind, we evaluated the cardiorespiratory clinical conditions, the changes in the intercostal muscles, the diaphragmatic mobility, and the respiratory cycles in Golden Retriever Muscular Dystrophy (GRMD) employing ultrasonography (US). A control group consisting of dogs of the same race, but not affected by muscular dystrophy, were used in this study. The results showed that inspiration, expiration and plateau movements (diaphragm mobility) were lower in the affected group. Plateau phase in the affected group was practically non-existent and showed that the diaphragm remained in constant motion. Respiratory rate reached 15.5 per minute for affected group and 26.93 per minute for the control group. Expiration and inspiration movements of intercostal muscles reached 8.99mm and 8.79mm, respectively, for control group and 7.42mm and 7.40mm, respectively, for affected group. Methodology used in the present analysis proved to be viable for the follow-up and evaluation of the respiratory model in GRMD and may be adapted to other muscular dystrophy experimental models. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000400290 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000400290 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-736X2016000400007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.36 n.4 2016 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
_version_ |
1754122235967176704 |