Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy

Detalhes bibliográficos
Autor(a) principal: Oliveira,Daniela M.
Data de Publicação: 2016
Outros Autores: Hagen,Stefano C., Santos,Amilton C., Miglino,Maria A., Assis Neto,Antônio C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Pesquisa Veterinária Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000400290
Resumo: Abstract Since respiratory insufficiency is the main cause of death in patients affected by Duchenne Muscular Dystrophy (DMD), the present study aims at establishing a new non-invasive method to evaluate the clinical parameters of respiratory conditions of experimental models affected by DMD. With this purpose in mind, we evaluated the cardiorespiratory clinical conditions, the changes in the intercostal muscles, the diaphragmatic mobility, and the respiratory cycles in Golden Retriever Muscular Dystrophy (GRMD) employing ultrasonography (US). A control group consisting of dogs of the same race, but not affected by muscular dystrophy, were used in this study. The results showed that inspiration, expiration and plateau movements (diaphragm mobility) were lower in the affected group. Plateau phase in the affected group was practically non-existent and showed that the diaphragm remained in constant motion. Respiratory rate reached 15.5 per minute for affected group and 26.93 per minute for the control group. Expiration and inspiration movements of intercostal muscles reached 8.99mm and 8.79mm, respectively, for control group and 7.42mm and 7.40mm, respectively, for affected group. Methodology used in the present analysis proved to be viable for the follow-up and evaluation of the respiratory model in GRMD and may be adapted to other muscular dystrophy experimental models.
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spelling Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular DystrophyRespiratory musclesDuchenne Muscular DystrophydiaphragmDMDGRMDultrasoundAbstract Since respiratory insufficiency is the main cause of death in patients affected by Duchenne Muscular Dystrophy (DMD), the present study aims at establishing a new non-invasive method to evaluate the clinical parameters of respiratory conditions of experimental models affected by DMD. With this purpose in mind, we evaluated the cardiorespiratory clinical conditions, the changes in the intercostal muscles, the diaphragmatic mobility, and the respiratory cycles in Golden Retriever Muscular Dystrophy (GRMD) employing ultrasonography (US). A control group consisting of dogs of the same race, but not affected by muscular dystrophy, were used in this study. The results showed that inspiration, expiration and plateau movements (diaphragm mobility) were lower in the affected group. Plateau phase in the affected group was practically non-existent and showed that the diaphragm remained in constant motion. Respiratory rate reached 15.5 per minute for affected group and 26.93 per minute for the control group. Expiration and inspiration movements of intercostal muscles reached 8.99mm and 8.79mm, respectively, for control group and 7.42mm and 7.40mm, respectively, for affected group. Methodology used in the present analysis proved to be viable for the follow-up and evaluation of the respiratory model in GRMD and may be adapted to other muscular dystrophy experimental models.Colégio Brasileiro de Patologia Animal - CBPA2016-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000400290Pesquisa Veterinária Brasileira v.36 n.4 2016reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/S0100-736X2016000400007info:eu-repo/semantics/openAccessOliveira,Daniela M.Hagen,Stefano C.Santos,Amilton C.Miglino,Maria A.Assis Neto,Antônio C.eng2016-07-15T00:00:00Zoai:scielo:S0100-736X2016000400290Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2016-07-15T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false
dc.title.none.fl_str_mv Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy
title Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy
spellingShingle Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy
Oliveira,Daniela M.
Respiratory muscles
Duchenne Muscular Dystrophy
diaphragm
DMD
GRMD
ultrasound
title_short Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy
title_full Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy
title_fullStr Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy
title_full_unstemmed Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy
title_sort Noninvasive evaluation of respiratory muscles in pre-clinical model of Duchenne Muscular Dystrophy
author Oliveira,Daniela M.
author_facet Oliveira,Daniela M.
Hagen,Stefano C.
Santos,Amilton C.
Miglino,Maria A.
Assis Neto,Antônio C.
author_role author
author2 Hagen,Stefano C.
Santos,Amilton C.
Miglino,Maria A.
Assis Neto,Antônio C.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Daniela M.
Hagen,Stefano C.
Santos,Amilton C.
Miglino,Maria A.
Assis Neto,Antônio C.
dc.subject.por.fl_str_mv Respiratory muscles
Duchenne Muscular Dystrophy
diaphragm
DMD
GRMD
ultrasound
topic Respiratory muscles
Duchenne Muscular Dystrophy
diaphragm
DMD
GRMD
ultrasound
description Abstract Since respiratory insufficiency is the main cause of death in patients affected by Duchenne Muscular Dystrophy (DMD), the present study aims at establishing a new non-invasive method to evaluate the clinical parameters of respiratory conditions of experimental models affected by DMD. With this purpose in mind, we evaluated the cardiorespiratory clinical conditions, the changes in the intercostal muscles, the diaphragmatic mobility, and the respiratory cycles in Golden Retriever Muscular Dystrophy (GRMD) employing ultrasonography (US). A control group consisting of dogs of the same race, but not affected by muscular dystrophy, were used in this study. The results showed that inspiration, expiration and plateau movements (diaphragm mobility) were lower in the affected group. Plateau phase in the affected group was practically non-existent and showed that the diaphragm remained in constant motion. Respiratory rate reached 15.5 per minute for affected group and 26.93 per minute for the control group. Expiration and inspiration movements of intercostal muscles reached 8.99mm and 8.79mm, respectively, for control group and 7.42mm and 7.40mm, respectively, for affected group. Methodology used in the present analysis proved to be viable for the follow-up and evaluation of the respiratory model in GRMD and may be adapted to other muscular dystrophy experimental models.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000400290
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2016000400290
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-736X2016000400007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
dc.source.none.fl_str_mv Pesquisa Veterinária Brasileira v.36 n.4 2016
reponame:Pesquisa Veterinária Brasileira (Online)
instname:Colégio Brasileiro de Patologia Animal (CBPA)
instacron:EMBRAPA
instname_str Colégio Brasileiro de Patologia Animal (CBPA)
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reponame_str Pesquisa Veterinária Brasileira (Online)
collection Pesquisa Veterinária Brasileira (Online)
repository.name.fl_str_mv Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)
repository.mail.fl_str_mv colegio@cbpa.org.br||pvb@pvb.com.br
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