Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits

Detalhes bibliográficos
Autor(a) principal: Aguirre,José Ignacio
Data de Publicação: 2005
Outros Autores: Gomar,María Soledad, Igal,Silvio, Quiroga,María Alejandra, Portiansky,Enrique Leo, Gimeno,Eduardo Juan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Pesquisa Veterinária Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2005000100008
Resumo: The aim of this study was to describe the bone changes observed after a daily oral administration of the calcinogenic plant Solanum malacoxylon (syn. S. glaucophyllum) (Sm) during 9 days. The Sm-poisoned rabbits had an increase of bone resorption in the endosteal surface of the cortical zone and also in the surface covered by osteoblasts of the primary and secondary spongiosa of the trabecular bone compartment. Moreover, the epiphyseal growth plates in long bones appeared narrower than in the control rabbits, with reduction of the proliferative and hyperthrophic chondrocyte zones. The electron microscopic study revealed a significant decrease of proteoglycans in the hyperthrophic chondrocyte zone evidenced by a significant reduction of rutenium red positive granules in the poisoned rabbit. Altogether, these data suggest that cell differentiation may play a pivotal role in the pathogenesis of Sm-induced bone lesions.
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spelling Bone changes caused by experimental Solanum malacoxylon poisoning in rabbitsSolanum malacoxylonS. glaucophyllumcalcinogenic plantrabbitbone tissuegrowth plateThe aim of this study was to describe the bone changes observed after a daily oral administration of the calcinogenic plant Solanum malacoxylon (syn. S. glaucophyllum) (Sm) during 9 days. The Sm-poisoned rabbits had an increase of bone resorption in the endosteal surface of the cortical zone and also in the surface covered by osteoblasts of the primary and secondary spongiosa of the trabecular bone compartment. Moreover, the epiphyseal growth plates in long bones appeared narrower than in the control rabbits, with reduction of the proliferative and hyperthrophic chondrocyte zones. The electron microscopic study revealed a significant decrease of proteoglycans in the hyperthrophic chondrocyte zone evidenced by a significant reduction of rutenium red positive granules in the poisoned rabbit. Altogether, these data suggest that cell differentiation may play a pivotal role in the pathogenesis of Sm-induced bone lesions.Colégio Brasileiro de Patologia Animal - CBPA2005-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2005000100008Pesquisa Veterinária Brasileira v.25 n.1 2005reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/S0100-736X2005000100008info:eu-repo/semantics/openAccessAguirre,José IgnacioGomar,María SoledadIgal,SilvioQuiroga,María AlejandraPortiansky,Enrique LeoGimeno,Eduardo Juaneng2005-06-13T00:00:00Zoai:scielo:S0100-736X2005000100008Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2005-06-13T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false
dc.title.none.fl_str_mv Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits
title Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits
spellingShingle Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits
Aguirre,José Ignacio
Solanum malacoxylon
S. glaucophyllum
calcinogenic plant
rabbit
bone tissue
growth plate
title_short Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits
title_full Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits
title_fullStr Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits
title_full_unstemmed Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits
title_sort Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits
author Aguirre,José Ignacio
author_facet Aguirre,José Ignacio
Gomar,María Soledad
Igal,Silvio
Quiroga,María Alejandra
Portiansky,Enrique Leo
Gimeno,Eduardo Juan
author_role author
author2 Gomar,María Soledad
Igal,Silvio
Quiroga,María Alejandra
Portiansky,Enrique Leo
Gimeno,Eduardo Juan
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Aguirre,José Ignacio
Gomar,María Soledad
Igal,Silvio
Quiroga,María Alejandra
Portiansky,Enrique Leo
Gimeno,Eduardo Juan
dc.subject.por.fl_str_mv Solanum malacoxylon
S. glaucophyllum
calcinogenic plant
rabbit
bone tissue
growth plate
topic Solanum malacoxylon
S. glaucophyllum
calcinogenic plant
rabbit
bone tissue
growth plate
description The aim of this study was to describe the bone changes observed after a daily oral administration of the calcinogenic plant Solanum malacoxylon (syn. S. glaucophyllum) (Sm) during 9 days. The Sm-poisoned rabbits had an increase of bone resorption in the endosteal surface of the cortical zone and also in the surface covered by osteoblasts of the primary and secondary spongiosa of the trabecular bone compartment. Moreover, the epiphyseal growth plates in long bones appeared narrower than in the control rabbits, with reduction of the proliferative and hyperthrophic chondrocyte zones. The electron microscopic study revealed a significant decrease of proteoglycans in the hyperthrophic chondrocyte zone evidenced by a significant reduction of rutenium red positive granules in the poisoned rabbit. Altogether, these data suggest that cell differentiation may play a pivotal role in the pathogenesis of Sm-induced bone lesions.
publishDate 2005
dc.date.none.fl_str_mv 2005-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2005000100008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2005000100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-736X2005000100008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
dc.source.none.fl_str_mv Pesquisa Veterinária Brasileira v.25 n.1 2005
reponame:Pesquisa Veterinária Brasileira (Online)
instname:Colégio Brasileiro de Patologia Animal (CBPA)
instacron:EMBRAPA
instname_str Colégio Brasileiro de Patologia Animal (CBPA)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Pesquisa Veterinária Brasileira (Online)
collection Pesquisa Veterinária Brasileira (Online)
repository.name.fl_str_mv Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)
repository.mail.fl_str_mv colegio@cbpa.org.br||pvb@pvb.com.br
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