Low dose of dichloroacetate infusion reduces blood lactate after submaximal exercise in horses

Detalhes bibliográficos
Autor(a) principal: Ferraz,Guilherme C.
Data de Publicação: 2013
Outros Autores: Brito,Helena C.D., Berkman,Carolina, Albernaz,Raquel M., Araújo,Renatha A., Silva,Matheus H.M., D'Angelis,Flora H. de F., Queiroz-Neto,Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Pesquisa Veterinária Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2013000100011
Resumo: The acute administration of an indirect activator of the enzyme pyruvate dehydrogenase (PDH) in human athletes causes a reduction in blood lactate level during and after exercise. A single IV dose (2.5m.kg-1) of dichloroacetate (DCA) was administered before a submaximal incremental exercise test (IET) with five velocity steps, from 5.0 m.s-1 for 1 min to 6.0, 6.5, 7.0 and 7.5m.s-1 every 30s in four untrained mares. The blood collections were done in the period after exercise, at times 1, 3, 5, 10, 15 and 20 min. Blood lactate and glucose (mM) were determined electro-enzymatically utilizing a YSI 2300 automated analyzer. There was a 15.3% decrease in mean total blood lactate determined from the values obtained at all assessment times in both trials after the exercise. There was a decrease in blood lactate 1, 3, 5, 10, 15 and 20 min after exercise for the mares that received prior DCA treatment, with respective mean values of 6.31±0.90 vs 5.81±0.50, 6.45±1.19 vs 5.58±1.06, 6.07±1.56 vs 5.26±1.12, 4.88±1.61 vs 3.95±1.00, 3.66±1.41 vs 2.86±0.75 and 2.75±0.51 vs 2.04±0.30. There was no difference in glucose concentrations. By means of linear regression analysis, V140, V160, V180 and V200 were determined (velocity at which the rate heart is 140, 160, 180, and 200 beats/minute, respectively). The velocities related to heart rate did not differ, indicating that there was no ergogenic effect, but prior administration of a relatively low dose of DCA in mares reduced lactatemia after an IET.
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spelling Low dose of dichloroacetate infusion reduces blood lactate after submaximal exercise in horsesEquinesodium dichloroacetatelactatemiaincremental exercise testThe acute administration of an indirect activator of the enzyme pyruvate dehydrogenase (PDH) in human athletes causes a reduction in blood lactate level during and after exercise. A single IV dose (2.5m.kg-1) of dichloroacetate (DCA) was administered before a submaximal incremental exercise test (IET) with five velocity steps, from 5.0 m.s-1 for 1 min to 6.0, 6.5, 7.0 and 7.5m.s-1 every 30s in four untrained mares. The blood collections were done in the period after exercise, at times 1, 3, 5, 10, 15 and 20 min. Blood lactate and glucose (mM) were determined electro-enzymatically utilizing a YSI 2300 automated analyzer. There was a 15.3% decrease in mean total blood lactate determined from the values obtained at all assessment times in both trials after the exercise. There was a decrease in blood lactate 1, 3, 5, 10, 15 and 20 min after exercise for the mares that received prior DCA treatment, with respective mean values of 6.31±0.90 vs 5.81±0.50, 6.45±1.19 vs 5.58±1.06, 6.07±1.56 vs 5.26±1.12, 4.88±1.61 vs 3.95±1.00, 3.66±1.41 vs 2.86±0.75 and 2.75±0.51 vs 2.04±0.30. There was no difference in glucose concentrations. By means of linear regression analysis, V140, V160, V180 and V200 were determined (velocity at which the rate heart is 140, 160, 180, and 200 beats/minute, respectively). The velocities related to heart rate did not differ, indicating that there was no ergogenic effect, but prior administration of a relatively low dose of DCA in mares reduced lactatemia after an IET.Colégio Brasileiro de Patologia Animal - CBPA2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2013000100011Pesquisa Veterinária Brasileira v.33 n.1 2013reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/S0100-736X2013000100011info:eu-repo/semantics/openAccessFerraz,Guilherme C.Brito,Helena C.D.Berkman,CarolinaAlbernaz,Raquel M.Araújo,Renatha A.Silva,Matheus H.M.D'Angelis,Flora H. de F.Queiroz-Neto,Antonioeng2013-03-06T00:00:00Zoai:scielo:S0100-736X2013000100011Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2013-03-06T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false
dc.title.none.fl_str_mv Low dose of dichloroacetate infusion reduces blood lactate after submaximal exercise in horses
title Low dose of dichloroacetate infusion reduces blood lactate after submaximal exercise in horses
spellingShingle Low dose of dichloroacetate infusion reduces blood lactate after submaximal exercise in horses
Ferraz,Guilherme C.
Equine
sodium dichloroacetate
lactatemia
incremental exercise test
title_short Low dose of dichloroacetate infusion reduces blood lactate after submaximal exercise in horses
title_full Low dose of dichloroacetate infusion reduces blood lactate after submaximal exercise in horses
title_fullStr Low dose of dichloroacetate infusion reduces blood lactate after submaximal exercise in horses
title_full_unstemmed Low dose of dichloroacetate infusion reduces blood lactate after submaximal exercise in horses
title_sort Low dose of dichloroacetate infusion reduces blood lactate after submaximal exercise in horses
author Ferraz,Guilherme C.
author_facet Ferraz,Guilherme C.
Brito,Helena C.D.
Berkman,Carolina
Albernaz,Raquel M.
Araújo,Renatha A.
Silva,Matheus H.M.
D'Angelis,Flora H. de F.
Queiroz-Neto,Antonio
author_role author
author2 Brito,Helena C.D.
Berkman,Carolina
Albernaz,Raquel M.
Araújo,Renatha A.
Silva,Matheus H.M.
D'Angelis,Flora H. de F.
Queiroz-Neto,Antonio
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferraz,Guilherme C.
Brito,Helena C.D.
Berkman,Carolina
Albernaz,Raquel M.
Araújo,Renatha A.
Silva,Matheus H.M.
D'Angelis,Flora H. de F.
Queiroz-Neto,Antonio
dc.subject.por.fl_str_mv Equine
sodium dichloroacetate
lactatemia
incremental exercise test
topic Equine
sodium dichloroacetate
lactatemia
incremental exercise test
description The acute administration of an indirect activator of the enzyme pyruvate dehydrogenase (PDH) in human athletes causes a reduction in blood lactate level during and after exercise. A single IV dose (2.5m.kg-1) of dichloroacetate (DCA) was administered before a submaximal incremental exercise test (IET) with five velocity steps, from 5.0 m.s-1 for 1 min to 6.0, 6.5, 7.0 and 7.5m.s-1 every 30s in four untrained mares. The blood collections were done in the period after exercise, at times 1, 3, 5, 10, 15 and 20 min. Blood lactate and glucose (mM) were determined electro-enzymatically utilizing a YSI 2300 automated analyzer. There was a 15.3% decrease in mean total blood lactate determined from the values obtained at all assessment times in both trials after the exercise. There was a decrease in blood lactate 1, 3, 5, 10, 15 and 20 min after exercise for the mares that received prior DCA treatment, with respective mean values of 6.31±0.90 vs 5.81±0.50, 6.45±1.19 vs 5.58±1.06, 6.07±1.56 vs 5.26±1.12, 4.88±1.61 vs 3.95±1.00, 3.66±1.41 vs 2.86±0.75 and 2.75±0.51 vs 2.04±0.30. There was no difference in glucose concentrations. By means of linear regression analysis, V140, V160, V180 and V200 were determined (velocity at which the rate heart is 140, 160, 180, and 200 beats/minute, respectively). The velocities related to heart rate did not differ, indicating that there was no ergogenic effect, but prior administration of a relatively low dose of DCA in mares reduced lactatemia after an IET.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2013000100011
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-736X2013000100011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
dc.source.none.fl_str_mv Pesquisa Veterinária Brasileira v.33 n.1 2013
reponame:Pesquisa Veterinária Brasileira (Online)
instname:Colégio Brasileiro de Patologia Animal (CBPA)
instacron:EMBRAPA
instname_str Colégio Brasileiro de Patologia Animal (CBPA)
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institution EMBRAPA
reponame_str Pesquisa Veterinária Brasileira (Online)
collection Pesquisa Veterinária Brasileira (Online)
repository.name.fl_str_mv Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)
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