Complement activation-related pseudoallergy in dogs following intravenous administration of a liposomal formulation of meglumine antimoniate
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Pesquisa Veterinária Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2013000800012 |
Resumo: | The increasing use of nanotechnologies in advanced therapies has allowed the observation of specific adverse reactions related to nanostructures. The toxicity of a novel liposome formulation of meglumine antimoniate in dogs with visceral leishmaniasis after single dose has been investigated. Groups of 12 animals received by the intravenous route a single dose of liposomal meglumine antimoniate (group I [GI], 6.5 mg Sb/kg), empty liposomes (GII) or isotonic saline (GIII). Evaluation of hematological and biochemical parameters showed no significant changes 4 days after administration. No undesired effects were registered in the GIII. However, adverse reactions were observed in 67.7% of dogs from both groups that received liposomal formulations. The side effects began moments after bolus administration and disappeared during the first 15 minutes after treatment. Prostation, sialorrhea and defecation were the most frequent clinical signs, registered in 33.3% and 41.6 % of animals from the groups GI and GII, respectively. Tachypnea, mydriasis, miosis, vomiting and cyanosis were also registered in both groups. The adverse reactions observed in this study were attributed to the activation of the complement system by lipid vesicles in a phenomenon known as Complement Activation-Related Pseudoallergy (CARPA). The influence of the physical-chemical characteristics of liposomal formulation in the triggering of CARPA is discussed. |
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Complement activation-related pseudoallergy in dogs following intravenous administration of a liposomal formulation of meglumine antimoniateHypersensitivity reactionsComplement Activation-Related Pseudoallergy (CARPA)liposomescomplement activationcanine leishmaniasisThe increasing use of nanotechnologies in advanced therapies has allowed the observation of specific adverse reactions related to nanostructures. The toxicity of a novel liposome formulation of meglumine antimoniate in dogs with visceral leishmaniasis after single dose has been investigated. Groups of 12 animals received by the intravenous route a single dose of liposomal meglumine antimoniate (group I [GI], 6.5 mg Sb/kg), empty liposomes (GII) or isotonic saline (GIII). Evaluation of hematological and biochemical parameters showed no significant changes 4 days after administration. No undesired effects were registered in the GIII. However, adverse reactions were observed in 67.7% of dogs from both groups that received liposomal formulations. The side effects began moments after bolus administration and disappeared during the first 15 minutes after treatment. Prostation, sialorrhea and defecation were the most frequent clinical signs, registered in 33.3% and 41.6 % of animals from the groups GI and GII, respectively. Tachypnea, mydriasis, miosis, vomiting and cyanosis were also registered in both groups. The adverse reactions observed in this study were attributed to the activation of the complement system by lipid vesicles in a phenomenon known as Complement Activation-Related Pseudoallergy (CARPA). The influence of the physical-chemical characteristics of liposomal formulation in the triggering of CARPA is discussed.Colégio Brasileiro de Patologia Animal - CBPA2013-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2013000800012Pesquisa Veterinária Brasileira v.33 n.8 2013reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/S0100-736X2013000800012info:eu-repo/semantics/openAccessRibeiro,Raul R.Moura,Eliane P.Sampaio,Weverton M.Silva,Sydnei M.Fulgêncio,Gustavo O.Tafuri,Wagner L.Michalick,Marilene S.M.Frézard,Frédériceng2013-09-13T00:00:00Zoai:scielo:S0100-736X2013000800012Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2013-09-13T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
Complement activation-related pseudoallergy in dogs following intravenous administration of a liposomal formulation of meglumine antimoniate |
title |
Complement activation-related pseudoallergy in dogs following intravenous administration of a liposomal formulation of meglumine antimoniate |
spellingShingle |
Complement activation-related pseudoallergy in dogs following intravenous administration of a liposomal formulation of meglumine antimoniate Ribeiro,Raul R. Hypersensitivity reactions Complement Activation-Related Pseudoallergy (CARPA) liposomes complement activation canine leishmaniasis |
title_short |
Complement activation-related pseudoallergy in dogs following intravenous administration of a liposomal formulation of meglumine antimoniate |
title_full |
Complement activation-related pseudoallergy in dogs following intravenous administration of a liposomal formulation of meglumine antimoniate |
title_fullStr |
Complement activation-related pseudoallergy in dogs following intravenous administration of a liposomal formulation of meglumine antimoniate |
title_full_unstemmed |
Complement activation-related pseudoallergy in dogs following intravenous administration of a liposomal formulation of meglumine antimoniate |
title_sort |
Complement activation-related pseudoallergy in dogs following intravenous administration of a liposomal formulation of meglumine antimoniate |
author |
Ribeiro,Raul R. |
author_facet |
Ribeiro,Raul R. Moura,Eliane P. Sampaio,Weverton M. Silva,Sydnei M. Fulgêncio,Gustavo O. Tafuri,Wagner L. Michalick,Marilene S.M. Frézard,Frédéric |
author_role |
author |
author2 |
Moura,Eliane P. Sampaio,Weverton M. Silva,Sydnei M. Fulgêncio,Gustavo O. Tafuri,Wagner L. Michalick,Marilene S.M. Frézard,Frédéric |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Ribeiro,Raul R. Moura,Eliane P. Sampaio,Weverton M. Silva,Sydnei M. Fulgêncio,Gustavo O. Tafuri,Wagner L. Michalick,Marilene S.M. Frézard,Frédéric |
dc.subject.por.fl_str_mv |
Hypersensitivity reactions Complement Activation-Related Pseudoallergy (CARPA) liposomes complement activation canine leishmaniasis |
topic |
Hypersensitivity reactions Complement Activation-Related Pseudoallergy (CARPA) liposomes complement activation canine leishmaniasis |
description |
The increasing use of nanotechnologies in advanced therapies has allowed the observation of specific adverse reactions related to nanostructures. The toxicity of a novel liposome formulation of meglumine antimoniate in dogs with visceral leishmaniasis after single dose has been investigated. Groups of 12 animals received by the intravenous route a single dose of liposomal meglumine antimoniate (group I [GI], 6.5 mg Sb/kg), empty liposomes (GII) or isotonic saline (GIII). Evaluation of hematological and biochemical parameters showed no significant changes 4 days after administration. No undesired effects were registered in the GIII. However, adverse reactions were observed in 67.7% of dogs from both groups that received liposomal formulations. The side effects began moments after bolus administration and disappeared during the first 15 minutes after treatment. Prostation, sialorrhea and defecation were the most frequent clinical signs, registered in 33.3% and 41.6 % of animals from the groups GI and GII, respectively. Tachypnea, mydriasis, miosis, vomiting and cyanosis were also registered in both groups. The adverse reactions observed in this study were attributed to the activation of the complement system by lipid vesicles in a phenomenon known as Complement Activation-Related Pseudoallergy (CARPA). The influence of the physical-chemical characteristics of liposomal formulation in the triggering of CARPA is discussed. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2013000800012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2013000800012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-736X2013000800012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.33 n.8 2013 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
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1754122233622560768 |