Vascular injury in spontaneous subacute toxicosis caused by organic arsenic in cattle

Detalhes bibliográficos
Autor(a) principal: Gonçalves,Maiara A.
Data de Publicação: 2017
Outros Autores: Cruz,Raquel A.S. da, Reis,Matheus O., Pavarini,Saulo P., Sonne,Luciana, Driemeier,David
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Pesquisa Veterinária Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000700676
Resumo: ABSTRACT: Monosodium methanearsonate (MSMA) is an organic form of arsenic present in the formulations of some herbicides. Accidental ingestion of pasture contaminated with arsenic may lead to toxicosis in cattle. Almost 200 head of cattle maintained in an area sprayed with MSMA presented with intense diarrhea and dehydration after grazing. Subsequently, 16 of these animals died. Toxic levels of arsenic (>1.5μg/g) were detected in the kidney, liver, urine, and skeletal muscle of 6 animals. At gross inspection were observed multifocal to coalescent ulcers in the mucosa from on the forestomachs associated with hemorrhagic areas and marked wall edema. Microscopic examination mainly showed fibrinoid necrosis of vessels with multifocal thrombosis associated with ischemic infarction that were characterized by large transmural necrotic areas in the forestomachs. The clinical and pathological changes interestingly showed that this form of arsenic although considered less toxic, has caused severe vascular injury in forestomachs of cattle.
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spelling Vascular injury in spontaneous subacute toxicosis caused by organic arsenic in cattleToxicosisorganic arseniccattleMSMAarsenic poisoningvascular necrosisABSTRACT: Monosodium methanearsonate (MSMA) is an organic form of arsenic present in the formulations of some herbicides. Accidental ingestion of pasture contaminated with arsenic may lead to toxicosis in cattle. Almost 200 head of cattle maintained in an area sprayed with MSMA presented with intense diarrhea and dehydration after grazing. Subsequently, 16 of these animals died. Toxic levels of arsenic (>1.5μg/g) were detected in the kidney, liver, urine, and skeletal muscle of 6 animals. At gross inspection were observed multifocal to coalescent ulcers in the mucosa from on the forestomachs associated with hemorrhagic areas and marked wall edema. Microscopic examination mainly showed fibrinoid necrosis of vessels with multifocal thrombosis associated with ischemic infarction that were characterized by large transmural necrotic areas in the forestomachs. The clinical and pathological changes interestingly showed that this form of arsenic although considered less toxic, has caused severe vascular injury in forestomachs of cattle.Colégio Brasileiro de Patologia Animal - CBPA2017-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000700676Pesquisa Veterinária Brasileira v.37 n.7 2017reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/s0100-736x2017000700004info:eu-repo/semantics/openAccessGonçalves,Maiara A.Cruz,Raquel A.S. daReis,Matheus O.Pavarini,Saulo P.Sonne,LucianaDriemeier,Davideng2017-10-27T00:00:00Zoai:scielo:S0100-736X2017000700676Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2017-10-27T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false
dc.title.none.fl_str_mv Vascular injury in spontaneous subacute toxicosis caused by organic arsenic in cattle
title Vascular injury in spontaneous subacute toxicosis caused by organic arsenic in cattle
spellingShingle Vascular injury in spontaneous subacute toxicosis caused by organic arsenic in cattle
Gonçalves,Maiara A.
Toxicosis
organic arsenic
cattle
MSMA
arsenic poisoning
vascular necrosis
title_short Vascular injury in spontaneous subacute toxicosis caused by organic arsenic in cattle
title_full Vascular injury in spontaneous subacute toxicosis caused by organic arsenic in cattle
title_fullStr Vascular injury in spontaneous subacute toxicosis caused by organic arsenic in cattle
title_full_unstemmed Vascular injury in spontaneous subacute toxicosis caused by organic arsenic in cattle
title_sort Vascular injury in spontaneous subacute toxicosis caused by organic arsenic in cattle
author Gonçalves,Maiara A.
author_facet Gonçalves,Maiara A.
Cruz,Raquel A.S. da
Reis,Matheus O.
Pavarini,Saulo P.
Sonne,Luciana
Driemeier,David
author_role author
author2 Cruz,Raquel A.S. da
Reis,Matheus O.
Pavarini,Saulo P.
Sonne,Luciana
Driemeier,David
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves,Maiara A.
Cruz,Raquel A.S. da
Reis,Matheus O.
Pavarini,Saulo P.
Sonne,Luciana
Driemeier,David
dc.subject.por.fl_str_mv Toxicosis
organic arsenic
cattle
MSMA
arsenic poisoning
vascular necrosis
topic Toxicosis
organic arsenic
cattle
MSMA
arsenic poisoning
vascular necrosis
description ABSTRACT: Monosodium methanearsonate (MSMA) is an organic form of arsenic present in the formulations of some herbicides. Accidental ingestion of pasture contaminated with arsenic may lead to toxicosis in cattle. Almost 200 head of cattle maintained in an area sprayed with MSMA presented with intense diarrhea and dehydration after grazing. Subsequently, 16 of these animals died. Toxic levels of arsenic (>1.5μg/g) were detected in the kidney, liver, urine, and skeletal muscle of 6 animals. At gross inspection were observed multifocal to coalescent ulcers in the mucosa from on the forestomachs associated with hemorrhagic areas and marked wall edema. Microscopic examination mainly showed fibrinoid necrosis of vessels with multifocal thrombosis associated with ischemic infarction that were characterized by large transmural necrotic areas in the forestomachs. The clinical and pathological changes interestingly showed that this form of arsenic although considered less toxic, has caused severe vascular injury in forestomachs of cattle.
publishDate 2017
dc.date.none.fl_str_mv 2017-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000700676
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000700676
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0100-736x2017000700004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
dc.source.none.fl_str_mv Pesquisa Veterinária Brasileira v.37 n.7 2017
reponame:Pesquisa Veterinária Brasileira (Online)
instname:Colégio Brasileiro de Patologia Animal (CBPA)
instacron:EMBRAPA
instname_str Colégio Brasileiro de Patologia Animal (CBPA)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Pesquisa Veterinária Brasileira (Online)
collection Pesquisa Veterinária Brasileira (Online)
repository.name.fl_str_mv Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)
repository.mail.fl_str_mv colegio@cbpa.org.br||pvb@pvb.com.br
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