Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Pesquisa Veterinária Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000500479 |
Resumo: | ABSTRACT: Paraneoplastic laboratory abnormalities are identified in several types of cancers in dogs and cats. In veterinary medicine, particularly in mammary cancer, there are few studies that correlate abnormal laboratory findings with tumor type and staging. The aim of this study was to evaluate hematological, biochemical, and hemostatic abnormalities and correlate them with mammary tumor staging in female dogs with mammary cancer. Blood samples from 24 female dogs were evaluated, and the hematological, biochemical, and hemostatic parameters were correlated with tumor staging obtained by physical examination, imaging exams, and histopathological surgical biopsies. The groups were organized according to tumor staging: group 1 (stages I and II), group 2 (stage III), and group 3 (stages IV and V). Anemia, neutrophilic leukocytosis, monocytosis, eosinophilia, thrombocytosis, hypoalbuminemia, hypocalcemia, hypoglycemia, and low blood urea were observed. The variables MCHC, TPP, and RDW were correlated with tumor staging with no clinical relevance. Thrombin time and fibrinogen were significant between the groups in the coagulation test, being associated with tumor staging. The findings suggest influence of the proinflammatory cytokines released during tumor growth. |
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Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasmsHyperfibrinogenemiamammary tumor stagingparaneoplastic syndromeslaboratory parametersABSTRACT: Paraneoplastic laboratory abnormalities are identified in several types of cancers in dogs and cats. In veterinary medicine, particularly in mammary cancer, there are few studies that correlate abnormal laboratory findings with tumor type and staging. The aim of this study was to evaluate hematological, biochemical, and hemostatic abnormalities and correlate them with mammary tumor staging in female dogs with mammary cancer. Blood samples from 24 female dogs were evaluated, and the hematological, biochemical, and hemostatic parameters were correlated with tumor staging obtained by physical examination, imaging exams, and histopathological surgical biopsies. The groups were organized according to tumor staging: group 1 (stages I and II), group 2 (stage III), and group 3 (stages IV and V). Anemia, neutrophilic leukocytosis, monocytosis, eosinophilia, thrombocytosis, hypoalbuminemia, hypocalcemia, hypoglycemia, and low blood urea were observed. The variables MCHC, TPP, and RDW were correlated with tumor staging with no clinical relevance. Thrombin time and fibrinogen were significant between the groups in the coagulation test, being associated with tumor staging. The findings suggest influence of the proinflammatory cytokines released during tumor growth.Colégio Brasileiro de Patologia Animal - CBPA2017-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000500479Pesquisa Veterinária Brasileira v.37 n.5 2017reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/s0100-736x2017000500009info:eu-repo/semantics/openAccessDuda,Naila C.B.Valle,Stella de F.Matheus,Juliana P.Angeli,Natália C.Vieira,Luciane C.Oliveira,Luciana O.Sonne,LucianaGonzález,Félix H.D.eng2017-08-29T00:00:00Zoai:scielo:S0100-736X2017000500479Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2017-08-29T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms |
title |
Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms |
spellingShingle |
Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms Duda,Naila C.B. Hyperfibrinogenemia mammary tumor staging paraneoplastic syndromes laboratory parameters |
title_short |
Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms |
title_full |
Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms |
title_fullStr |
Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms |
title_full_unstemmed |
Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms |
title_sort |
Paraneoplastic hematological, biochemical, and hemostatic abnormalities in female dogs with mammary neoplasms |
author |
Duda,Naila C.B. |
author_facet |
Duda,Naila C.B. Valle,Stella de F. Matheus,Juliana P. Angeli,Natália C. Vieira,Luciane C. Oliveira,Luciana O. Sonne,Luciana González,Félix H.D. |
author_role |
author |
author2 |
Valle,Stella de F. Matheus,Juliana P. Angeli,Natália C. Vieira,Luciane C. Oliveira,Luciana O. Sonne,Luciana González,Félix H.D. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Duda,Naila C.B. Valle,Stella de F. Matheus,Juliana P. Angeli,Natália C. Vieira,Luciane C. Oliveira,Luciana O. Sonne,Luciana González,Félix H.D. |
dc.subject.por.fl_str_mv |
Hyperfibrinogenemia mammary tumor staging paraneoplastic syndromes laboratory parameters |
topic |
Hyperfibrinogenemia mammary tumor staging paraneoplastic syndromes laboratory parameters |
description |
ABSTRACT: Paraneoplastic laboratory abnormalities are identified in several types of cancers in dogs and cats. In veterinary medicine, particularly in mammary cancer, there are few studies that correlate abnormal laboratory findings with tumor type and staging. The aim of this study was to evaluate hematological, biochemical, and hemostatic abnormalities and correlate them with mammary tumor staging in female dogs with mammary cancer. Blood samples from 24 female dogs were evaluated, and the hematological, biochemical, and hemostatic parameters were correlated with tumor staging obtained by physical examination, imaging exams, and histopathological surgical biopsies. The groups were organized according to tumor staging: group 1 (stages I and II), group 2 (stage III), and group 3 (stages IV and V). Anemia, neutrophilic leukocytosis, monocytosis, eosinophilia, thrombocytosis, hypoalbuminemia, hypocalcemia, hypoglycemia, and low blood urea were observed. The variables MCHC, TPP, and RDW were correlated with tumor staging with no clinical relevance. Thrombin time and fibrinogen were significant between the groups in the coagulation test, being associated with tumor staging. The findings suggest influence of the proinflammatory cytokines released during tumor growth. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000500479 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000500479 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s0100-736x2017000500009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.37 n.5 2017 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
_version_ |
1754122237034627072 |