In vitro activity of Benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole in goat gastrointestinal nematodes

Detalhes bibliográficos
Autor(a) principal: Vieira, Luiz da Silva
Data de Publicação: 2014
Outros Autores: Gonçalves, Pedro Cabral, Costa, Carlos Alberto Fagonde, Berne, Maria Elizabeth Aires
Tipo de documento: Artigo
Idioma: por
Título da fonte: Pesquisa Agropecuária Brasileira (Online)
Texto Completo: https://seer.sct.embrapa.br/index.php/pab/article/view/16450
Resumo: This study was carried out to determine and to compare the "in vitro" activity of the benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole on caprine gastrointestinal nematodes. Fecal cultures were performed and treated with benzimidazole anthelminths using five different concentrations: 6.25, 12.5, 25.0, 50.0 and 100.0 ppm. Five fecal cultures were prepared for each concentration, using distilled water in the control cultures. Thiabendazole and albendazole, showed the highest reduction percentage of infective larvae of Haemonchus, Strongyloides and of free living females of Stongyloides. Oxfendazole ranked in an intermediate position, and fenbendazole had the lowest efficacy. Against the infective larvae of Trichostrongylus, oxfendazole, albendazole and thiabendazole had efficacy higher than 95%, whereas fenbendazole was lower 95.0%. Infective larvae of Oesophagostomum were reduced by all four benzimidazoles tested with efficiencies above 96%.
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spelling In vitro activity of Benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole in goat gastrointestinal nematodesAtividade in vitro dos benzimidazóis: oxfendazole, fenbedazole, albendazole e thiabendazole em nematódeos gastrintestinais de caprinosfecal culture; anthelmintics; helminth control; infective larvaecoprocultura; anti-helmínticos; larvas infectantes.This study was carried out to determine and to compare the "in vitro" activity of the benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole on caprine gastrointestinal nematodes. Fecal cultures were performed and treated with benzimidazole anthelminths using five different concentrations: 6.25, 12.5, 25.0, 50.0 and 100.0 ppm. Five fecal cultures were prepared for each concentration, using distilled water in the control cultures. Thiabendazole and albendazole, showed the highest reduction percentage of infective larvae of Haemonchus, Strongyloides and of free living females of Stongyloides. Oxfendazole ranked in an intermediate position, and fenbendazole had the lowest efficacy. Against the infective larvae of Trichostrongylus, oxfendazole, albendazole and thiabendazole had efficacy higher than 95%, whereas fenbendazole was lower 95.0%. Infective larvae of Oesophagostomum were reduced by all four benzimidazoles tested with efficiencies above 96%.O trabalho foi executado com o objetivo de determinar e comparar a atividade "in vitro" dos benzimidazóis: oxfendazole, fenbendazole, albendazole e thiabendazole em nematódeos gastrintestinais, de caprinos. Para isto, realizaram-se coproculturas que foram tratadas com anti-helmínticos benzimidazóis, em cinco concentrações diferentes: 6,25; 12,5; 25,0; 50,0 e 100,0 ppm, para cada um dos produtos, com cinco coproculturas por concentração. Grupos de coproculturas que serviram de testemunha receberam água destilada. O thiabendazole e o albendazole, independentemente da concentração testada, apresentaram os maiores percentuais de redução de larvas infectantes de Haemonchus, Strongyloides e fêmeas, de Strongyloides de vida livre, ficando o oxfendazole numa posição intermediária e o fenbendazote na posição mais baixa. Para larvas infectantes de Trichostrongylus, o oxfendazole, o albendazole e o thiabendazole apresentaram percentagem de redução acima de 95,0%, sendo que o fenbendazole apresentou percentuais de redução inferiores a 95,0%. Para as larvas infectantes de Oesophagostomum, os quatro benzimidazóis testados apresentaram percentagens de redução acima de 96,0%.Pesquisa Agropecuaria BrasileiraPesquisa Agropecuária BrasileiraVieira, Luiz da SilvaGonçalves, Pedro CabralCosta, Carlos Alberto FagondeBerne, Maria Elizabeth Aires2014-04-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.sct.embrapa.br/index.php/pab/article/view/16450Pesquisa Agropecuaria Brasileira; v.24, n.10, out. 1989; 1201-1209Pesquisa Agropecuária Brasileira; v.24, n.10, out. 1989; 1201-12091678-39210100-104xreponame:Pesquisa Agropecuária Brasileira (Online)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPAporhttps://seer.sct.embrapa.br/index.php/pab/article/view/16450/10716info:eu-repo/semantics/openAccess2014-08-29T16:47:27Zoai:ojs.seer.sct.embrapa.br:article/16450Revistahttp://seer.sct.embrapa.br/index.php/pabPRIhttps://old.scielo.br/oai/scielo-oai.phppab@sct.embrapa.br || sct.pab@embrapa.br1678-39210100-204Xopendoar:2014-08-29T16:47:27Pesquisa Agropecuária Brasileira (Online) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv In vitro activity of Benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole in goat gastrointestinal nematodes
Atividade in vitro dos benzimidazóis: oxfendazole, fenbedazole, albendazole e thiabendazole em nematódeos gastrintestinais de caprinos
title In vitro activity of Benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole in goat gastrointestinal nematodes
spellingShingle In vitro activity of Benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole in goat gastrointestinal nematodes
Vieira, Luiz da Silva
fecal culture; anthelmintics; helminth control; infective larvae
coprocultura; anti-helmínticos; larvas infectantes.
title_short In vitro activity of Benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole in goat gastrointestinal nematodes
title_full In vitro activity of Benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole in goat gastrointestinal nematodes
title_fullStr In vitro activity of Benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole in goat gastrointestinal nematodes
title_full_unstemmed In vitro activity of Benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole in goat gastrointestinal nematodes
title_sort In vitro activity of Benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole in goat gastrointestinal nematodes
author Vieira, Luiz da Silva
author_facet Vieira, Luiz da Silva
Gonçalves, Pedro Cabral
Costa, Carlos Alberto Fagonde
Berne, Maria Elizabeth Aires
author_role author
author2 Gonçalves, Pedro Cabral
Costa, Carlos Alberto Fagonde
Berne, Maria Elizabeth Aires
author2_role author
author
author
dc.contributor.none.fl_str_mv

dc.contributor.author.fl_str_mv Vieira, Luiz da Silva
Gonçalves, Pedro Cabral
Costa, Carlos Alberto Fagonde
Berne, Maria Elizabeth Aires
dc.subject.por.fl_str_mv fecal culture; anthelmintics; helminth control; infective larvae
coprocultura; anti-helmínticos; larvas infectantes.
topic fecal culture; anthelmintics; helminth control; infective larvae
coprocultura; anti-helmínticos; larvas infectantes.
description This study was carried out to determine and to compare the "in vitro" activity of the benzimidazoles: oxfendazole, fenbendazole, albendazole and thiabendazole on caprine gastrointestinal nematodes. Fecal cultures were performed and treated with benzimidazole anthelminths using five different concentrations: 6.25, 12.5, 25.0, 50.0 and 100.0 ppm. Five fecal cultures were prepared for each concentration, using distilled water in the control cultures. Thiabendazole and albendazole, showed the highest reduction percentage of infective larvae of Haemonchus, Strongyloides and of free living females of Stongyloides. Oxfendazole ranked in an intermediate position, and fenbendazole had the lowest efficacy. Against the infective larvae of Trichostrongylus, oxfendazole, albendazole and thiabendazole had efficacy higher than 95%, whereas fenbendazole was lower 95.0%. Infective larvae of Oesophagostomum were reduced by all four benzimidazoles tested with efficiencies above 96%.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-17
dc.type.none.fl_str_mv
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.sct.embrapa.br/index.php/pab/article/view/16450
url https://seer.sct.embrapa.br/index.php/pab/article/view/16450
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.sct.embrapa.br/index.php/pab/article/view/16450/10716
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Pesquisa Agropecuaria Brasileira
Pesquisa Agropecuária Brasileira
publisher.none.fl_str_mv Pesquisa Agropecuaria Brasileira
Pesquisa Agropecuária Brasileira
dc.source.none.fl_str_mv Pesquisa Agropecuaria Brasileira; v.24, n.10, out. 1989; 1201-1209
Pesquisa Agropecuária Brasileira; v.24, n.10, out. 1989; 1201-1209
1678-3921
0100-104x
reponame:Pesquisa Agropecuária Brasileira (Online)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Pesquisa Agropecuária Brasileira (Online)
collection Pesquisa Agropecuária Brasileira (Online)
repository.name.fl_str_mv Pesquisa Agropecuária Brasileira (Online) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv pab@sct.embrapa.br || sct.pab@embrapa.br
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